DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPRF and Ptp52F

DIOPT Version :10

Sequence 1:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens
Sequence 2:NP_611093.2 Gene:Ptp52F / 36790 FlyBaseID:FBgn0034085 Length:1433 Species:Drosophila melanogaster


Alignment Length:1592 Identity:368/1592 - (23%)
Similarity:583/1592 - (36%) Gaps:499/1592 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   267 VKWMMG--------------AEELTKEDEMPVGRNVLELS-NVVRSANYTCVAI----SSLGMIE 312
            :.|:.|              ::||.::.|:.|...|..|. ::...|:|:...:    .|....|
  Fly    19 ILWIAGVQGQTVGSLVAVSESQELAEKVEVTVVSTVYTLGFSISNEADYSIDKVICRNGSGSETE 83

Human   313 ATA-------------------QVTVKALPKPPIDLVV---TE-----TTATSVT-------LTW 343
            |.|                   :..|...| ||.|..:   ||     ||.|||.       :||
  Fly    84 ANAAHVCENLNPCTFYTSVVSFRSNVSGKP-PPSDQTIYAYTEYKQPKTTVTSVVATANTIKVTW 147

Human   344 DSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAV 408
            .:.:...|..:||..:|......||.::..::..:.  .||....:...:...|:......::|.
  Fly   148 QTNDRACVESFGITAKATDYTKSFQLLNDKSSQTFV--NLSACLTHTITLDTRNNASVVVDTDAT 210

Human   409 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHN--T 471
            ...|....|......| ..:.|..|| :.|..|.|.| .:..| |:          .|.:::  |
  Fly   211 DVDTQYAEPGDLVMNV-TNLASGITM-ITWGDPSEKN-CISNY-VF----------KWQRNDCGT 261

Human   472 DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW 536
            |....||........|..:..:..|.:...|.:|:.:||.:          ..:|.||.:::   
  Fly   262 DQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSDEVKCE----------WTDVSSDGKLR--- 313

Human   537 LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQL------AARSDMGVG 595
                                             .|.|.||:...||.||:      .|::..   
  Fly   314 ---------------------------------EYLLTDLQGCDLYTFQVFINENSTAKASQ--- 342

Human   596 VFTPTIEARTAQSTPS-------------APPQKVMCVSMGSTTVRVSWVPPPADSRN---GVIT 644
            .||...:..:|...||             :|.....||:..|.|:    ..|...|.|   .|||
  Fly   343 TFTSAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKCVANYSVTL----TGPIQRSENKTMNVIT 403

Human   645 QYSVA-YEAVD----------------------------GEDRGRHVVDGISREHS-----SW-- 673
            :.:.| ::.:|                            |||:...:.|.:....:     ||  
  Fly   404 EETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVSWKT 468

Human   674 --------DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNST--- 727
                    |...|..|.|                         :|      :.||||.|:.|   
  Fly   469 PEYADLCIDGYRLSGWME-------------------------DD------KLVEVEALSITTQN 502

Human   728 ----------AVHVYWKLPVP-SKQH--GQIRGYQV---------TYVRLE-------------- 756
                      |..||....:| :|::  ||:|...|         |.|:||              
  Fly   503 TTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAF 567

Human   757 NGE-PRGLPIIQDVMLAEA--QWRPEESEDY---------ETTISGLTPETTYSVTVAAYTTKGD 809
            |.: ....|.|..:....|  |.|...:|.|         ..::|.|:|..||...|..|...|.
  Fly   568 NADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKVILYNVAGP 632

Human   810 GARSKPKI---VTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR------- 863
               |:|.:   :.||...|.:| ::|:..:.:::.|..|.||....|.:..|:....|       
  Fly   633 ---SEPVVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFV 694

Human   864 -ADEA--RPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQN 925
             ||.|  ..:|....|.|.....|||.....|:.::||:|..|:|...|..|..  .||:.....
  Fly   695 PADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGI--TLPAVSDSV 757

Human   926 LHVTGLT----------TSTTELAWDPPVLAERNGRIISYTVVFRDINSQ----QELQNITTDT- 975
            ..:|.||          .:...:.|..|  .:.||.|..:.:.|....:.    ...:.:..|| 
  Fly   758 TQLTVLTQGPVNNNAVYEANVTITWKVP--CKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTG 820

Human   976 ------RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLL 1034
                  .:|.|.::|...|.::|             |:::|  .|||           :.:||..
  Fly   821 NKQGRMSYTETEMQPQFDYTVEV-------------SVKNR--DVEQ-----------LSSSVPG 859

Human  1035 SWEVPDSYKSAVPFKILYNGQSVEVDGHS------MRKLIADLQPNTEYS---FVLMNRGSSAGG 1090
            ||:.|....: :|...|.......|:..|      :.:|.||:..:....   ..||....:..|
  Fly   860 SWQSPAGLPT-IPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNCAG 923

Human  1091 LQHL---VSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLT 1152
            :.||   || ...|.:|.::...|     ||..|.|:.:                      ....
  Fly   924 VPHLKYDVS-SDWPKVLSYQEAGA-----DGTGDCSLEY----------------------QTTE 960

Human  1153 PRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLG-DK--KNYRGFY 1214
            .||. ||.::                |:||..|     |.:..:::   ||:| ||  :..:.:.
  Fly   961 ERWH-PEPVQ----------------RQRRDGE-----VTSDEEIV---FTIGLDKCSEVQKTYC 1000

Human  1215 NRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILII 1279
            |.||.||..|...|          :.:.:|.|||..|:.             :.|...:.|.||:
  Fly  1001 NGPLLPDTDYNVVV----------RLFTASGYSDAAVLN-------------FKTKAAIKVTLIL 1042

Human  1280 LIVIAIL----------LFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSVPS 1334
            :.|.:.|          |:.|||.   :.|.:...|::|                          
  Fly  1043 VSVCSCLLLAFVLGLTVLWVRKRL---AWKRDSGQGIED-------------------------- 1078

Human  1335 CPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYAN 1398
             |..:.:..:..|..|::|      |..   |.::|::.|. ...:.::..|.|..:  |||||:
  Fly  1079 -PFGNVIAKNFAIFYTEVA------KPE---KLAREFKEITVVALELSYSASELGCH--KNRYAD 1131

Human  1399 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVM 1463
            :..||.:|||| .|| ..|||||||::|||:.::..|||||||.||::.|||||:.:.....:|.
  Fly  1132 IFPYDKNRVIL-DID-AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ 1194

Human  1464 MTRLEEKSRVKCDQYWP--ARGTETCGLIQVTL--LDTVELATYTVRTFALHKSGSSEKRELRQF 1524
            :|:..|.:.:||.:|:|  .||      :.||:  .:.:||...|..|....|.|..||  :..:
  Fly  1195 VTQFREGNTIKCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTVVHDKYGLKEK--VIHY 1251

Human  1525 QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTV 1589
            .|..||||||||.|..::.|:::|||.......|:||||||||||||.||.:|.:::|:|.|..:
  Fly  1252 YFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKI 1316

Human  1590 DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1621
            :|:..|..:|.||..||||:.||.|::....|
  Fly  1317 NIFETVKKLRFQRMKMVQTQQQYTFLYACTYE 1348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRFXP_005271136.1 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 136..226 CDD:409400
Ig strand A 136..138 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 190..195 CDD:409400
Ig strand F 204..211 CDD:409400
Ig strand G 214..225 CDD:409400
IgI_3_RPTP_IIa_LAR_like 239..320 CDD:409401 14/90 (16%)
Ig strand A 239..241 CDD:409401
Ig strand A' 245..249 CDD:409401
Ig strand B 252..260 CDD:409401
Ig strand C 265..271 CDD:409401 1/3 (33%)
Ig strand C' 273..275 CDD:409401 0/1 (0%)
Ig strand D 278..282 CDD:409401 0/3 (0%)
Ig strand E 287..292 CDD:409401 1/4 (25%)
Ig strand F 299..306 CDD:409401 1/10 (10%)
Ig strand G 310..319 CDD:409401 3/27 (11%)
FN3 <311..716 CDD:442628 91/506 (18%)
FN3 714..820 CDD:238020 37/159 (23%)
FN3 825..914 CDD:238020 27/99 (27%)
FN3 923..1011 CDD:238020 17/108 (16%)
FN3 1020..>1079 CDD:238020 12/67 (18%)
R-PTPc-F-1 1350..1625 CDD:350474 110/277 (40%)
R-PTP-F-2 1627..1917 CDD:350477
Ptp52FNP_611093.2 FN3 648..749 CDD:238020 27/102 (26%)
PTPc 1100..1345 CDD:214550 106/256 (41%)
Blue background indicates that the domain is not in the aligned region.

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