DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPRF and Lar

DIOPT Version :10

Sequence 1:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:2084 Identity:962/2084 - (46%)
Similarity:1260/2084 - (60%) Gaps:248/2084 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    17 ALVMLGLVAGAH-----GDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-- 74
            :|::|.|:...|     ....|..|:.|::|....||||||.|.|.|:|.|.|.|.|.|||||  
  Fly    15 SLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGT 79

Human    75 SQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE-INTSAKLSVLEEEQLPPGFPSID 138
            ..|:.|:| ..|..|:|||:|:|..||:|.|||.|.|.:|: ::..|.|::.|.::.|.|||.|.
  Fly    80 QSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVIT 143

Human   139 MGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQG 203
            .||..:|:|...|..|.|.|.|||.|.|.|.|:...||  .||.|. .|:.|.||||:|.|.|||
  Fly   144 QGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVD--MSNPRY-SLKDGFLQIENSREEDQG 205

Human   204 KYECVATNSAGTRYSAPANLYVRDQREVRRVAPRFSIPPSS-QEVMPGGSVNLTCVAVGAPMPYV 267
            ||||||.||.||.:|...||||:    ||||.|.||.||.: .|||.|.::||:|:|||:|||:|
  Fly   206 KYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHV 266

Human   268 KWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVT 332
            |||.|:|:||.|:|||:|||||:|.|:..||||||:|.|:||.|::.:.|.|::||..|.|:.::
  Fly   267 KWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQIS 331

Human   333 ETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN 397
            |.|||||.|.|.....|.:.||.|||:.......|.|:.|:.|..|.:..|||::||.|.|:|||
  Fly   332 EVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVN 396

Human   398 SIGRGPPSEAVRARTGE-----QAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP 457
            :|||||||......||:     ....|.||.||.|.||:|||::.|||||.|||.|.||:||||.
  Fly   397 NIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTT 461

Human   458 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 522
            :|.:|..:|:....|...||||..|.|...|::||.|:|::|.||.|..:|||.|||||:||::|
  Fly   462 NSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNF 526

Human   523 QAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQ 585
            :|....:|.:.|.|..|  ..|.|:.||| ||.....:|.|......:.:|||:.|.|||||...
  Fly   527 RATDIGETAVTLQWTKPTHSSENIVHYEL-YWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIW 590

Human   586 LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 650
            |||||..|.|..||.|..||.|.  .|||:.:..::..|||:.:||:|||.:..||.|..|.|.:
  Fly   591 LAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFF 653

Human   651 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGP 715
            ..|..||   .....::...:|..|..|::||||::||.|.|.||.||.|.|:::||.|||| |.
  Fly   654 VEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GD 714

Human   716 PRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL---PIIQDVMLAEAQWR 777
            |:.|:..|||||::||.||.|:...::|.||||.:....|.: |.:|.   |...||:       
  Fly   715 PQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD-EGKGFLNEPFKFDVV------- 771

Human   778 PEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL- 841
                :..|..::||.|:|.||:.|||.|.||||.||...:|.|.|.||.|||:.:........: 
  Fly   772 ----DTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVS 832

Human   842 --LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 904
              |:|..|.:..|||.||||::...|:|....:..|..........|.:|..|.||:|..|..|:
  Fly   833 IELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGI 897

Human   905 GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF-----RDINS 964
            |:|..|..:|||..|.|.|.|:.:...|.....:.||||....|||.|..|.|.|     ..:.|
  Fly   898 GQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGS 962

Human   965 QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK---NFRVAA 1026
            ::.:    |..:...|.|:.:|.|..:|||:|.:|:||.|..:...|   |:...:   :.:..|
  Fly   963 ERNM----TLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET---ERDMGRAPMSLQAEA 1020

Human  1027 AMKTSVLLSWEVPDSYKSAVPFKILYNGQSVE-VDGHSMRKL-------IADLQPNTEYSFVLMN 1083
            ..:.:..:.||...|....:.:||.|...:|| :|....:.:       :.:|:...:|:..:..
  Fly  1021 TSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAA 1085

Human  1084 R-GSSAGGLQHLVSIRTAPD--------------------------------------------- 1102
            | .:..|.|...|::|..|:                                             
  Fly  1086 RFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQ 1150

Human  1103 ------LLPHKPLPASAYIEDGRFDLSMPHV---------------------------------- 1127
                  ::|.:.:....|::....:...|..                                  
  Fly  1151 GFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMV 1215

Human  1128 ---------------------QDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIE 1171
                                 ::...:..:|:||||.|:      :.....|::...|:||..  
  Fly  1216 KPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDK------SNLHKIPDQFLTDDLLPG-- 1272

Human  1172 QGGEEQRRRRRQAERLK-PYVAAQLD--VLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLK 1233
                     |.:.||.. ||:||:..  .:|.||.||...:|..|.||.|..:..|:.||.|.:.
  Fly  1273 ---------RNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVD 1328

Human  1234 EPMDQKR-YASSPYSDEIVV----------------------QVTPAQQQEEPEMLWVTGPVLAV 1275
            .|  ||. |.|||:|:.:.:                      :|:..:.::|||:|||..|::..
  Fly  1329 TP--QKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVS 1391

Human  1276 ILII---LIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAH------SSDPVEMRRLNYQTPGSS 1331
            ..|:   |||:.::    ||...|....:|:...:..:.|.      .||||:|||||:||||  
  Fly  1392 TFIVSTALIVLCVV----KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPG-- 1450

Human  1332 VPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRY 1396
                     |..||||||::.|::|||||:||..|||||||||:|||||||:|||||.||.||||
  Fly  1451 ---------MISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRY 1506

Human  1397 ANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1461
            |||.|||||||.|.:::||.|||||||||.|||||.|||:||||||.||..|||||.||.:|||:
  Fly  1507 ANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATI 1571

Human  1462 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1526
            ||||||||::|:|||||||.|||||.|.|.||:.:|.|||||::|||.|.:.|.:::||::|.||
  Fly  1572 VMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQF 1636

Human  1527 MAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDI 1591
            .||||||||::|.|.|.||||.:|..|.::||::||||||||||||:||||:|||||||||.:||
  Fly  1637 TAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDI 1701

Human  1592 YGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMEL 1656
            ||||||:|:||||||||||||:|||:|:|||..||.||||||||:.|:|||....|||:::.||:
  Fly  1702 YGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEV 1766

Human  1657 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQ 1721
            |||.|::.|..:|:|::|||||||.|||||:|:|||.:||.|.||.|:|||||:||||:||||.:
  Fly  1767 EFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYR 1831

Human  1722 KAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE 1786
            .||||.|||:.::.||||||||||||||:||||||:|||||||.||||.|||.||||:||||:||
  Fly  1832 SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAE 1896

Human  1787 YNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1851
            ||||||.||||||||||||.|||:|||||.|||||||||:|||||||||||||||||||||||||
  Fly  1897 YNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIT 1961

Human  1852 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS 1916
            |||||||||:|||||||||||||:||||:|:||||:.||:||||||||||||..|||||||||||
  Fly  1962 VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026

Human  1917 FDHY 1920
            ||:|
  Fly  2027 FDNY 2030

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRFXP_005271136.1 I-set 33..124 CDD:400151 44/93 (47%)
Ig strand B 50..54 CDD:409353 3/3 (100%)
Ig strand C 63..67 CDD:409353 1/3 (33%)
Ig strand E 86..93 CDD:409353 3/6 (50%)
Ig strand F 104..109 CDD:409353 3/4 (75%)
Ig strand G 117..120 CDD:409353 0/2 (0%)
IgI_2_RPTP_IIa_LAR_like 136..226 CDD:409400 46/89 (52%)
Ig strand A 136..138 CDD:409400 0/1 (0%)
Ig strand A' 143..147 CDD:409400 1/3 (33%)
Ig strand B 150..159 CDD:409400 3/8 (38%)
Ig strand C 164..170 CDD:409400 3/5 (60%)
Ig strand C' 172..174 CDD:409400 0/1 (0%)
Ig strand D 183..187 CDD:409400 1/3 (33%)
Ig strand E 190..195 CDD:409400 3/4 (75%)
Ig strand F 204..211 CDD:409400 6/6 (100%)
Ig strand G 214..225 CDD:409400 5/10 (50%)
IgI_3_RPTP_IIa_LAR_like 239..320 CDD:409401 47/81 (58%)
Ig strand A 239..241 CDD:409401 1/1 (100%)
Ig strand A' 245..249 CDD:409401 2/3 (67%)
Ig strand B 252..260 CDD:409401 3/7 (43%)
Ig strand C 265..271 CDD:409401 4/5 (80%)
Ig strand C' 273..275 CDD:409401 0/1 (0%)
Ig strand D 278..282 CDD:409401 1/3 (33%)
Ig strand E 287..292 CDD:409401 3/4 (75%)
Ig strand F 299..306 CDD:409401 5/6 (83%)
Ig strand G 310..319 CDD:409401 2/8 (25%)
FN3 <311..716 CDD:442628 180/411 (44%)
FN3 714..820 CDD:238020 42/108 (39%)
FN3 825..914 CDD:238020 28/91 (31%)
FN3 923..1011 CDD:238020 28/92 (30%)
FN3 1020..>1079 CDD:238020 12/69 (17%)
R-PTPc-F-1 1350..1625 CDD:350474 196/274 (72%)
R-PTP-F-2 1627..1917 CDD:350477 225/289 (78%)
LarNP_001260594.1 I-set 36..129 CDD:400151 44/93 (47%)
Ig strand B 53..57 CDD:409353 3/3 (100%)
Ig strand C 66..70 CDD:409353 1/3 (33%)
Ig strand E 93..97 CDD:409353 2/3 (67%)
Ig strand F 108..113 CDD:409353 3/4 (75%)
Ig strand G 122..125 CDD:409353 0/2 (0%)
Ig 141..228 CDD:472250 46/89 (52%)
Ig strand B 157..161 CDD:409353 1/3 (33%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 192..196 CDD:409353 2/3 (67%)
Ig strand F 206..211 CDD:409353 4/4 (100%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 47/81 (58%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 2/3 (67%)
Ig strand B 251..259 CDD:409401 3/7 (43%)
Ig strand C 264..270 CDD:409401 4/5 (80%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 1/3 (33%)
Ig strand E 286..291 CDD:409401 3/4 (75%)
Ig strand F 298..305 CDD:409401 5/6 (83%)
Ig strand G 309..318 CDD:409401 2/8 (25%)
FN3 322..411 CDD:238020 39/88 (44%)
FN3 <382..747 CDD:442628 169/371 (46%)
FN3 712..810 CDD:238020 43/110 (39%)
FN3 832..898 CDD:214495 21/65 (32%)
FN3 <867..1269 CDD:442628 76/414 (18%)
fn3 914..998 CDD:394996 28/87 (32%)
R-PTPc-LAR-1 1498..1735 CDD:350401 168/236 (71%)
R-PTP-LAR-2 1784..2021 CDD:350402 195/236 (83%)

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