DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRF and Pez

DIOPT Version :10

Sequence 1:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens
Sequence 2:NP_609013.1 Gene:Pez / 33882 FlyBaseID:FBgn0031799 Length:1252 Species:Drosophila melanogaster


Alignment Length:1220 Identity:250/1220 - (20%)
Similarity:408/1220 - (33%) Gaps:402/1220 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   561 HKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ------------------ 607
            |.||.| ..:..:|..|.|       ...|.:|..:|:   ||.||:                  
  Fly   266 HTVTID-KRTIKIEQNKLD-------GGGSIVGSFIFS---EADTARYFWKLTISQHKFFKRYID 319

Human   608 -STPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHS 671
             :|||         |:||          .||:.:|.:...||.|  ||.:.......:.:.:.|.
  Fly   320 TATPS---------SLGS----------GADAESGPLGVDSVGY--VDYDYNEAAAAEQLQQHHQ 363

Human   672 SWDLVGLEKWTEYRVWVRAHTDVGPGP-----ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHV 731
            ....:..::..:.:..:.::..:....     :||..|..::.::.|           :|..:| 
  Fly   364 QQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHS-----------SSGMLH- 416

Human   732 YWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI--SGLTPE 794
                      ||......      .|.|...|    ..||  ..:||  :.||||.:  ...||.
  Fly   417 ----------HGGSNNNN------NNDERERL----KAML--PTYRP--APDYETAVQLKYRTPS 457

Human   795 TTYSVTVAAYTTKGDG--ARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWH------PPKELP 851
            ..:.....|....|:.  |.|:|.:..     ||         ..|..||..|      |....|
  Fly   458 AEFHNVALAMAAPGNAYYAGSQPDVHN-----PG---------MHNENLLYGHMTAHRYPDVAQP 508

Human   852 GELLGYRLQYCRAD---EARPNTIDFGK------DDQHFTVTGLHKG-TTYIFRLAAKNRAGLGE 906
            ...|.:.:...:|.   ::.|..:...:      ...|..   .||. ..|:.||::.:...|. 
  Fly   509 AAALHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMM---RHKAPPPYVNRLSSSSTPDLA- 569

Human   907 EFEKEIRTPEDLPSGF--------------------------PQNLHVTGLTTST---------- 935
                 :.||..| .||                          |...|...:.||:          
  Fly   570 -----VATPRPL-QGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQY 628

Human   936 -TELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 999
             :.:....|.|....        .|.::|..:|..:|.:..|                ::..|:.
  Fly   629 VSHMGHSQPYLPPHG--------TFENLNMIEEQPSIMSQLR----------------QSAMSQA 669

Human  1000 SGPLSPSIQSRTMPVEQVFAKNFRVAA-AMKTSVLLSWEVPDSYKSAVPFKI---LYNGQSVEVD 1060
            :...:.|:.:::.|.  :....:|.:. ...:|.|....|..|:|||.|..:   |.||      
  Fly   670 AAAAAGSVVTQSSPT--LPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRSLVNG------ 726

Human  1061 GHSMRKLIADLQPNTEYSFVLMNR--GSSAGGL------QHLVSIRTAPDLLPHKPLPASAYIED 1117
                     .::|..| :..|..|  |.|:|..      |...||::||.::   |:||:.....
  Fly   727 ---------SIEPIYE-NVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVV---PVPAARNASS 778

Human  1118 GRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRR 1182
            ..                  :|.|.::           |.|::..:                ::.
  Fly   779 NN------------------VVTVTVN-----------SPPDDGNI----------------KKY 798

Human  1183 QAERLKPYVAAQLDVL---PETFTLGDKKNYRGFYNRPLS--PDLSYQCFVLASLKEPMDQKRYA 1242
            .|:|     ||..::|   |:    ..|:.     ||..|  ||:        ....|..|.|..
  Fly   799 GADR-----AASTELLFLEPQ----APKRT-----NRAASAAPDM--------GATPPPRQHRST 841

Human  1243 SSPYSDEIVVQVTPA----QQQEEPEMLWVTGPVLAVILIILIV------IAILLFKRK------ 1291
            :|......|..:|||    |||.....|..........:....:      .|....|||      
  Fly   842 ASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFL 906

Human  1292 -RTHSPSSKDEQSIGLKDSLLA--HSSDPVEMR----RLNYQTPGSSVPSCPNTSSMRDHPPIPI 1349
             |:.:|..:...::|.:.:..|  ||....:::    .||          .||..|...:.|.||
  Fly   907 SRSKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLN----------LPNRWSTGVNKPQPI 961

Human  1350 T-----DLADNIERLKANDGLKFSQEYESIDPGQQFT-WENSNLEVNKPKNRYANVIAYDHSRVI 1408
            :     |....|...|.:|...| .|:|.|...::.. :|.:.||.|:|||...|.:.||.:||.
  Fly   962 SGRYSKDKLCQILDQKLSDSQLF-MEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVR 1025

Human  1409 LTSIDGVPGSD----YINANYIDGY--RKQNAYIATQGPL-PETMGDFWRMVWEQRTATVVMMTR 1466
            ||     |..|    |:||:.|...  .||..||..|.|. |.||..||:.|||.....||.:| 
  Fly  1026 LT-----PCRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLT- 1084

Human  1467 LEEKS--------RVKCDQYWP----ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKR 1519
             |:.|        |::..|:..    ::.|:.|        .|::|..|.|        .|...|
  Fly  1085 -EDMSYIPRNSHQRLEFGQFQVYQEFSQTTDRC--------TTIKLRLYHV--------PSRRYR 1132

Human  1520 ELRQFQFMAWPDHGVPEYPTPILAFLRRVKA--------------CNPLDAGPMVVHCSAGVGRT 1570
            .:...|:..|.:...|......|.||..:.:              .||    |:::||..|.||:
  Fly  1133 SVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNP----PVLLHCLEGGGRS 1193

Human  1571 GCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1620
            |..:..|.:|..:.|.:.:||...:..:|.||:.::.:..||.||:..|:
  Fly  1194 GVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI 1243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRFXP_005271136.1 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 136..226 CDD:409400
Ig strand A 136..138 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 190..195 CDD:409400
Ig strand F 204..211 CDD:409400
Ig strand G 214..225 CDD:409400
IgI_3_RPTP_IIa_LAR_like 239..320 CDD:409401
Ig strand A 239..241 CDD:409401
Ig strand A' 245..249 CDD:409401
Ig strand B 252..260 CDD:409401
Ig strand C 265..271 CDD:409401
Ig strand C' 273..275 CDD:409401
Ig strand D 278..282 CDD:409401
Ig strand E 287..292 CDD:409401
Ig strand F 299..306 CDD:409401
Ig strand G 310..319 CDD:409401
FN3 <311..716 CDD:442628 33/178 (19%)
FN3 714..820 CDD:238020 22/109 (20%)
FN3 825..914 CDD:238020 18/104 (17%)
FN3 923..1011 CDD:238020 13/98 (13%)
FN3 1020..>1079 CDD:238020 14/62 (23%)
R-PTPc-F-1 1350..1625 CDD:350474 85/310 (27%)
R-PTP-F-2 1627..1917 CDD:350477
PezNP_609013.1 FERM_F1_PTPN14_like 17..107 CDD:340619
FERM_M 112..230 CDD:459788
FERM_C_PTPN14_PTPN21 225..317 CDD:270009 14/61 (23%)
PTP_DSP_cys 1036..1246 CDD:475123 61/230 (27%)
Blue background indicates that the domain is not in the aligned region.

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