DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRF and Ptp10D

DIOPT Version :9

Sequence 1:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens
Sequence 2:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster


Alignment Length:1677 Identity:416/1677 - (24%)
Similarity:653/1677 - (38%) Gaps:441/1677 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   151 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY-----ECVAT 210
            |.|:..|    |||              .||..: |:|||...|.......||.|     :.:..
  Fly   116 TVTITTA----PDP--------------PSNLSV-QVRSGKNAIILWSPPTQGSYTAFKIKVLGL 161

Human   211 NSAGTRYSAPANLYVRD---QREVRRVAP-----------------------RFSIPPSSQEVMP 249
            :.|.:.|:  ....|.|   |..|:.:.|                       .|:..|::    |
  Fly   162 SEASSSYN--RTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNT----P 220

Human   250 GGSV----NLTCVAV--GAPMP---YVKWMMGAEE---------LTKEDEMPVGRNVLELSNVVR 296
            |..:    |.|.:.|  ..|.|   |..:.:..|.         :.||.| |.|........:|.
  Fly   221 GKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGE-PPGPAQAAFKGLVP 284

Human   297 SANYTCVAISSLGMIEATAQVTV--KALPKPPIDLVVTE--TTATSVTLTWDS--GNSEPVTYYG 355
            ...|. :::.::...|.:...|.  :.:|..|:::....  .|:.|..:.|::  |.||...|  
  Fly   285 GRAYN-ISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKY-- 346

Human   356 IQYRAAGTEGPFQEVDGVATTRYSIGGLS--PFSEYAFRVLAVNSIGRGPPSEA--VRARTGEQA 416
                         :|....|.|.|....|  |.:.:.||.:|       .|.:.  |..:|....
  Fly   347 -------------QVSVATTRRQSTVPRSNEPVAFFDFRDIA-------EPGKTFNVIVKTVSGK 391

Human   417 PSSPP-------RRVQARML------SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHK 468
            .:|.|       |.:..|.|      ..:||::.||  .:|......||:.|        :....
  Fly   392 VTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWE--ADPASTQDEYRIVY--------HELET 446

Human   469 HNTDAGLLT------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVE 527
            .|.|...||      |:.|||||..|||.|.|.:...:...: :|.|.|:   |:.|      :.
  Fly   447 FNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNET-SIFVVTR---PSSP------II 501

Human   528 SDTR-----IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLA 587
            .|.:     :.:||......:...||::|......|.:.:.|.:  |...:::|:|...|..::.
  Fly   502 EDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKE--SRLVIKNLQPGAGYELKVF 564

Human   588 ARSDMGVGVFTPTIEARTAQSTPSA--------PPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT 644
            |.|             ...:|.|.|        ||:.:...::.|.:|.|.|.||    .:|..|
  Fly   565 AVS-------------HDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP----ESGEFT 612

Human   645 QYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDE 709
            :||:.|. .|.|.:...:....|.|....|:...||:|     ::.:| |..|.| |||....:.
  Fly   613 EYSIRYR-TDSEQQWVRLPSVRSTEADITDMTKGEKYT-----IQVNT-VSFGVE-SPVPQEVNT 669

Human   710 DVPSGPPRKVEVEPLNSTAVHVYWKLPV-----------PSKQHGQIRGYQV---------TYVR 754
            .||..|...: ::.::|..:.:.|..|.           ||...|:::...|         :.||
  Fly   670 TVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVR 733

Human   755 LENGE--------------------------PRGLPIIQ-DVMLAEAQWRPEESEDYETTIS--- 789
            :..||                          ||.:|:|| ||::|..     |.||...||:   
  Fly   734 VLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANG-----EKEDERDTITLSY 793

Human   790 GLTPETTYSVTVAAYTTKGDGARSKPKI-------VTTTGAVPGRPTMMISTTAMNTALLQWHPP 847
            ..||:::....:..::......|.|.|:       ||.||.||||   :.:.|.       |   
  Fly   794 TPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGR---LYNITV-------W--- 845

Human   848 KELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 912
             .:.|.:....:|  |.|...|..|                                        
  Fly   846 -TVSGGVASLPIQ--RQDRLYPEPI---------------------------------------- 867

Human   913 RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQEL-QNITTDTR 976
                       ..||.|.:|.:...|.||.| ..|.|...|:|      :.:...| ||:||...
  Fly   868 -----------TQLHATNITDTEISLRWDLP-KGEYNDFDIAY------LTADNLLAQNMTTRNE 914

Human   977 FTLTGLKP--DTTYDIKVRAWTS----KGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLS 1035
            .|::.|:|  :.|:.:.||:.|.    :.|.|||.|..:......:|  :.|.......:.:...
  Fly   915 ITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRV--ERFHPTDVQPSEINFE 977

Human  1036 WEVPDSYKSAV--PFKILYNG------------QSVEVDGHSMRKLIADLQPNTEYSFVLMNRGS 1086
            |.:|.|..:.|  .|.|.|..            :|.|..|     :|.:|:|...|.|.:..:.:
  Fly   978 WSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFG-----VIKNLKPGETYVFKIQAKTA 1037

Human  1087 SAGGLQHLVSIRTAPDLLPHKP----LPASAYIEDGRFDLSM--PHVQDPS-LVRWFYIVVVPID 1144
            ...|.:.... :|.|.|.|.:|    :|...|.......:..  .:..|.: .||.:.|:|...|
  Fly  1038 IGFGPEREYR-QTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDD 1101

Human  1145 RVGGSML-TPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKK 1208
            ....|.| .|.|...:...:....:||:                 ||...: :...|.||:|.:.
  Fly  1102 AKNASGLEMPSWLDVQSYSVWLPYQAID-----------------PYYPFE-NRSVEDFTIGTEN 1148

Human  1209 --NYR-GFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTG 1270
              |:: |:.|.||....:|:..|.|.    ....::..:.||       .|.|..::...|.|..
  Fly  1149 CDNHKIGYCNGPLKSGTTYRVKVRAF----TGADKFTDTAYS-------FPIQTDQDNTSLIVAI 1202

Human  1271 PVLAVILIILIVIAILLFKRKRTH----SPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSS 1331
            .|...|:::|:| .:|.:||:|.:    :..|:...::.|.||:       :|..|         
  Fly  1203 TVPLTIILVLLV-TLLFYKRRRNNCRKTTKDSRANDNMSLPDSV-------IEQNR--------- 1250

Human  1332 VPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWENSNLEVNKPKNR 1395
                          ||.|.:.|::...:.|:...:||:|:|.: ..|:......::|..|:||||
  Fly  1251 --------------PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNR 1301

Human  1396 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT 1460
            :.|::.|||||..|..:|...|||||||||:.|:.....:|.|||||..|..|||||.||..:..
  Fly  1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366

Human  1461 VVMMTRLEEKSRVKCDQYWPARGTETC----GLIQVTLLDTVELATYTVRTFALHKSGSSEKREL 1521
            :||:||..||.|.|||||||   .:|.    |.|:|.:|:....|.:.:..|.|.:  .||:|.|
  Fly  1367 IVMLTRCFEKGREKCDQYWP---NDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRIL 1426

Human  1522 RQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE 1586
            |.|.|..|||.|||..|..::.|:|..:.....:..|:||||||||||:|.||.:|.:|:::...
  Fly  1427 RHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS 1491

Human  1587 KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV--PARNLY 1636
            ..|||:|.|..||.:|.:|||||.||:.||:.|| |...|...:  |||.::
  Fly  1492 DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREMH 1542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRFXP_005271136.1 I-set 33..124 CDD:254352
Ig 50..121 CDD:143165
I-set 135..225 CDD:254352 18/78 (23%)
Ig2_RPTP_IIa_LAR_like 152..226 CDD:143215 17/78 (22%)
IG_like 242..319 CDD:214653 18/94 (19%)
Ig3_RPTP_IIa_LAR_like 250..318 CDD:143216 16/85 (19%)
FN3 323..412 CDD:238020 20/96 (21%)
FN3 419..511 CDD:238020 30/110 (27%)
FN3 516..605 CDD:238020 16/93 (17%)
fn3 613..700 CDD:278470 24/86 (28%)
FN3 714..820 CDD:238020 31/162 (19%)
FN3 825..914 CDD:238020 11/88 (13%)
FN3 923..1011 CDD:238020 29/94 (31%)
FN3 1020..>1079 CDD:238020 15/72 (21%)
PTPc 1366..1621 CDD:214550 115/259 (44%)
PTPc 1392..1621 CDD:238006 108/232 (47%)
PTPc 1657..1912 CDD:214550
PTPc 1682..1912 CDD:238006
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 19/97 (20%)
fn3 220..304 CDD:278470 17/85 (20%)
fn3 315..391 CDD:278470 20/97 (21%)
FN3 405..494 CDD:238020 27/99 (27%)
FN3 511..574 CDD:238020 14/77 (18%)
FN3 583..671 CDD:238020 28/99 (28%)
fn3 683..753 CDD:278470 11/69 (16%)
fn3 787..850 CDD:278470 17/76 (22%)
fn3 866..935 CDD:278470 24/126 (19%)
fn3 961..1043 CDD:278470 18/88 (20%)
PTPc 1272..1525 CDD:214550 114/257 (44%)
PTPc 1298..1525 CDD:238006 107/231 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.