DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPRF and Ptp4E

DIOPT Version :9

Sequence 1:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens
Sequence 2:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster


Alignment Length:1769 Identity:398/1769 - (22%)
Similarity:647/1769 - (36%) Gaps:500/1769 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    64 ITWMKKGK-KVSSQRFEVIEFDD----------------------GAGSVLRIQPLRVQRDEAIY 105
            |||...|. :.|..|..|:...|                      ..|...::|...|.:.:...
  Fly   169 ITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESV 233

Human   106 ECTATNSLGEINTSAK----------LSVLEEEQLPPGFPS---IDMGPQLKVVEKARTATMLCA 157
            ..|:.|...:.||..|          |.||.:...|.|..:   :.:.|.    :..::...:..
  Fly   234 AYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPD----DAIQSVLYVER 294

Human   158 AGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQ----GKY------------- 205
            .|..|.|..:.||..:|       ||...:   ::|..|.:|:..    .:|             
  Fly   295 EGEPPGPAQAAFKGLVP-------GREYNI---SVQTVSEDETSSVPTTARYLTVPERVLNVTFD 349

Human   206 ECVATNSA-GTRYSAPANLYVRDQREV-----RRVAPRFSIPPSSQ---------EVM-PGGSVN 254
            |...|:|: ..|:..|......|..:|     ||:   |::|.::.         ::: ||.:..
  Fly   350 EAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRI---FNVPRAANGDSVYFDYPDILEPGRTYE 411

Human   255 LTCVAVG--------------APMP---------------YVKW-----------MMGAEELTKE 279
            :....:.              .|.|               ::.|           .:...|.|..
  Fly   412 VVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNA 476

Human   280 DEMP----------VGRNVLE--LSNVVRSANYTCVAISSL--GMIEATAQVTVKALPKPPIDLV 330
            .|:|          :..|:.|  |.:::....| .:|:.:|  |:....:.:|....|..|: :.
  Fly   477 SEVPAPFPVAAESQITTNLTEYTLDSLLAGRRY-LIAVQALSKGVASNASDITRYTRPAAPL-IQ 539

Human   331 VTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVAT--TRYSIGGLSPFSEYAFRV 393
            ...:....:.|:|.|..:.....|.:.|:..||    :|...:||  |..:|..|.|.|.|..:|
  Fly   540 ELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGT----REERTMATNETSLTIHYLHPGSGYEVKV 600

Human   394 LAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPD 458
            .|::...|..|....:|     ....||:.:..:.:..:.:::.|:.||..:  ...|.|.|..|
  Fly   601 HAISHGVRSEPHSYFQA-----VFPKPPQNLTLQTVHTNLVVLHWQAPEGSD--FSEYVVRYRTD 658

Human   459 SRRPPNAWHK----HNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQP 519
            :    :.|.:    |..:|    .:..:..|..|.::|   ..|..|..||. .::....:|.||
  Fly   659 A----SPWQRISGLHENEA----RIKDMHYGERYLVQV---NTVSFGVESPH-PLELNVTMPPQP 711

Human   520 ADFQAEVESDTRIQLSWLLP-PQERIIMYELVYWAAEDEDQQHKVTF----------DPTSSYTL 573
            ......:.....:.|.|  | |...:..|.|.:|..::||   :|.|          .|:....:
  Fly   712 VSNVVPLVDSRNLTLEW--PRPDGHVDFYTLKWWPTDEED---RVEFKNVTQLEDLSSPSVRIPI 771

Human   574 EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG-----STTVRVSWVP 633
            |||.|...|||::.|.|: |:...|..:..||.....|    .|...:.|     ..|:.:|:.|
  Fly   772 EDLSPGRQYRFEVQASSN-GIRSGTTHLSTRTMPLIQS----DVFIANAGHEQGQDETITLSYTP 831

Human   634 PPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR--VWVRAHTDVGP 696
            .||||....|.::|:....:..:::   :.:...|:.|   ..||.....|.  ||.     |..
  Fly   832 TPADSTRFDIYRFSMGDPTIKDKEK---LANDTERKLS---FSGLTPGKLYNVTVWT-----VSG 885

Human   697 GPESSPV--LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 759
            |..|.||  |.|. ..:|....:.::|.   :..:.::|..|.     |:...:::.|:..:...
  Fly   886 GVASLPVQRLYRL-HPLPISDLKAIQVA---AREITLHWTAPA-----GEYTDFELQYLSADEEA 941

Human   760 PRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGA-----------RS 813
            |:   ::|:|           :::.|.|:.||.|...|:.||...:....|.           ||
  Fly   942 PQ---LLQNV-----------TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRS 992

Human   814 KPKI---VTTTGAVPGR-PTMMISTTAMNTALLQWH-PPKELPGELLGYRLQYCRADEARP-NTI 872
            ...|   ..|..|.||: .....|.........:|. .|.|..|.:..:|:....||:|.. ::.
  Fly   993 SAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSY 1057

Human   873 DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL----TT 933
            :|..:.....:.||..|..||||:.||:..|.|.|.| .|:|...|....|:. .||.|    |:
  Fly  1058 EFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAERE-HIQTMPILAPPVPEP-SVTPLEVSRTS 1120

Human   934 STTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSK 998
            ||.|:::.....:..:|.:.|||::            |..|.....:||:               
  Fly  1121 STIEISFRQGYFSNAHGMVRSYTII------------IAEDVGKNASGLE--------------- 1158

Human   999 GSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHS 1063
                         ||                     ||:...:|...:|:      |::|     
  Fly  1159 -------------MP---------------------SWQDVQAYTVWLPY------QAIE----- 1178

Human  1064 MRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQ 1128
                                                     |:.|                    
  Fly  1179 -----------------------------------------PYNP-------------------- 1182

Human  1129 DPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA 1193
                                 .||...|....||                               
  Fly  1183 ---------------------FLTSNGSRKSSLE------------------------------- 1195

Human  1194 QLDVLPETFTLGD---KKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVT 1255
                 .|.||:|.   .|:..|:.|.||....:|:..:.|.    .|:.::..:.||..|..   
  Fly  1196 -----AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAF----TDEDKFTDTVYSSPITT--- 1248

Human  1256 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEM 1320
                 |..:.:.|...|.||:|:.::::.:....|.:....:||           ||...|.:..
  Fly  1249 -----ERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASK-----------LARMQDELAA 1297

Human  1321 RRLNYQTPGSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1384
            ....|.||               :.|:.:.|.:::...:.|:...:||:|:|.: ..|:......
  Fly  1298 LPEGYITP---------------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSF 1347

Human  1385 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1449
            :||..|:||||:.|::.|||||..|..:|...|||||||||:.|:.....:|.|||||..|..:|
  Fly  1348 ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEF 1412

Human  1450 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATYTVRTFALHKS 1513
            |||.||..:..:||:||..||.|.|||||||. |.....|.|:|.|:.......:::..|.:  |
  Fly  1413 WRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV--S 1475

Human  1514 GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1578
            .:.|.|.:|.|.|..|||.||||.|..::.|:|..:.....|..|::|||||||||:|.||.:|.
  Fly  1476 RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDR 1540

Human  1579 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG 1643
            :|:.:.....|||:|.|..||.:|.:|||||.|||.||:.|| |...|...:.|.:|..|..   
  Fly  1541 ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLELHAN--- 1601

Human  1644 QVPPGESVTAMELE 1657
               .|..||.:.||
  Fly  1602 ---DGYEVTKIYLE 1612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRFXP_005271136.1 I-set 33..124 CDD:254352 17/92 (18%)
Ig 50..121 CDD:143165 15/79 (19%)
I-set 135..225 CDD:254352 18/110 (16%)
Ig2_RPTP_IIa_LAR_like 152..226 CDD:143215 17/91 (19%)
IG_like 242..319 CDD:214653 16/140 (11%)
Ig3_RPTP_IIa_LAR_like 250..318 CDD:143216 15/121 (12%)
FN3 323..412 CDD:238020 23/90 (26%)
FN3 419..511 CDD:238020 19/95 (20%)
FN3 516..605 CDD:238020 26/99 (26%)
fn3 613..700 CDD:278470 20/93 (22%)
FN3 714..820 CDD:238020 20/119 (17%)
FN3 825..914 CDD:238020 26/91 (29%)
FN3 923..1011 CDD:238020 16/91 (18%)
FN3 1020..>1079 CDD:238020 6/58 (10%)
PTPc 1366..1621 CDD:214550 114/256 (45%)
PTPc 1392..1621 CDD:238006 106/229 (46%)
PTPc 1657..1912 CDD:214550 1/1 (100%)
PTPc 1682..1912 CDD:238006
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 13/72 (18%)
fn3 247..328 CDD:278470 18/94 (19%)
fn3 343..417 CDD:278470 13/76 (17%)
fn3 443..525 CDD:278470 12/82 (15%)
FN3 548..611 CDD:238020 19/66 (29%)
FN3 620..706 CDD:238020 19/99 (19%)
fn3 708..796 CDD:278470 25/93 (27%)
fn3 824..886 CDD:278470 17/72 (24%)
fn3 902..978 CDD:278470 17/97 (18%)
fn3 1013..1092 CDD:278470 21/78 (27%)
UP_III_II 1106..>1248 CDD:297589 46/336 (14%)
PTPc 1329..1582 CDD:214550 113/254 (44%)
PTPc 1355..1582 CDD:238006 105/228 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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