DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRF and Ptp4E

DIOPT Version :10

Sequence 1:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens
Sequence 2:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster


Alignment Length:1769 Identity:398/1769 - (22%)
Similarity:647/1769 - (36%) Gaps:500/1769 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    64 ITWMKKGK-KVSSQRFEVIEFDD----------------------GAGSVLRIQPLRVQRDEAIY 105
            |||...|. :.|..|..|:...|                      ..|...::|...|.:.:...
  Fly   169 ITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESV 233

Human   106 ECTATNSLGEINTSAK----------LSVLEEEQLPPGFPS---IDMGPQLKVVEKARTATMLCA 157
            ..|:.|...:.||..|          |.||.:...|.|..:   :.:.|.    :..::...:..
  Fly   234 AYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPD----DAIQSVLYVER 294

Human   158 AGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQ----GKY------------- 205
            .|..|.|..:.||..:|       ||...:   ::|..|.:|:..    .:|             
  Fly   295 EGEPPGPAQAAFKGLVP-------GREYNI---SVQTVSEDETSSVPTTARYLTVPERVLNVTFD 349

Human   206 ECVATNSA-GTRYSAPANLYVRDQREV-----RRVAPRFSIPPSSQ---------EVM-PGGSVN 254
            |...|:|: ..|:..|......|..:|     ||:   |::|.::.         ::: ||.:..
  Fly   350 EAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRI---FNVPRAANGDSVYFDYPDILEPGRTYE 411

Human   255 LTCVAVG--------------APMP---------------YVKW-----------MMGAEELTKE 279
            :....:.              .|.|               ::.|           .:...|.|..
  Fly   412 VVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNA 476

Human   280 DEMP----------VGRNVLE--LSNVVRSANYTCVAISSL--GMIEATAQVTVKALPKPPIDLV 330
            .|:|          :..|:.|  |.:::....| .:|:.:|  |:....:.:|....|..|: :.
  Fly   477 SEVPAPFPVAAESQITTNLTEYTLDSLLAGRRY-LIAVQALSKGVASNASDITRYTRPAAPL-IQ 539

Human   331 VTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVAT--TRYSIGGLSPFSEYAFRV 393
            ...:....:.|:|.|..:.....|.:.|:..||    :|...:||  |..:|..|.|.|.|..:|
  Fly   540 ELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGT----REERTMATNETSLTIHYLHPGSGYEVKV 600

Human   394 LAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPD 458
            .|::...|..|....:|     ....||:.:..:.:..:.:::.|:.||..:  ...|.|.|..|
  Fly   601 HAISHGVRSEPHSYFQA-----VFPKPPQNLTLQTVHTNLVVLHWQAPEGSD--FSEYVVRYRTD 658

Human   459 SRRPPNAWHK----HNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQP 519
            :    :.|.:    |..:|    .:..:..|..|.::|   ..|..|..||. .::....:|.||
  Fly   659 A----SPWQRISGLHENEA----RIKDMHYGERYLVQV---NTVSFGVESPH-PLELNVTMPPQP 711

Human   520 ADFQAEVESDTRIQLSWLLP-PQERIIMYELVYWAAEDEDQQHKVTF----------DPTSSYTL 573
            ......:.....:.|.|  | |...:..|.|.:|..::||   :|.|          .|:....:
  Fly   712 VSNVVPLVDSRNLTLEW--PRPDGHVDFYTLKWWPTDEED---RVEFKNVTQLEDLSSPSVRIPI 771

Human   574 EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG-----STTVRVSWVP 633
            |||.|...|||::.|.|: |:...|..:..||.....|    .|...:.|     ..|:.:|:.|
  Fly   772 EDLSPGRQYRFEVQASSN-GIRSGTTHLSTRTMPLIQS----DVFIANAGHEQGQDETITLSYTP 831

Human   634 PPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR--VWVRAHTDVGP 696
            .||||....|.::|:....:..:::   :.:...|:.|   ..||.....|.  ||.     |..
  Fly   832 TPADSTRFDIYRFSMGDPTIKDKEK---LANDTERKLS---FSGLTPGKLYNVTVWT-----VSG 885

Human   697 GPESSPV--LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 759
            |..|.||  |.|. ..:|....:.::|.   :..:.::|..|.     |:...:::.|:..:...
  Fly   886 GVASLPVQRLYRL-HPLPISDLKAIQVA---AREITLHWTAPA-----GEYTDFELQYLSADEEA 941

Human   760 PRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGA-----------RS 813
            |:   ::|:|           :::.|.|:.||.|...|:.||...:....|.           ||
  Fly   942 PQ---LLQNV-----------TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRS 992

Human   814 KPKI---VTTTGAVPGR-PTMMISTTAMNTALLQWH-PPKELPGELLGYRLQYCRADEARP-NTI 872
            ...|   ..|..|.||: .....|.........:|. .|.|..|.:..:|:....||:|.. ::.
  Fly   993 SAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSY 1057

Human   873 DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL----TT 933
            :|..:.....:.||..|..||||:.||:..|.|.|.| .|:|...|....|:. .||.|    |:
  Fly  1058 EFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAERE-HIQTMPILAPPVPEP-SVTPLEVSRTS 1120

Human   934 STTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSK 998
            ||.|:::.....:..:|.:.|||::            |..|.....:||:               
  Fly  1121 STIEISFRQGYFSNAHGMVRSYTII------------IAEDVGKNASGLE--------------- 1158

Human   999 GSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHS 1063
                         ||                     ||:...:|...:|:      |::|     
  Fly  1159 -------------MP---------------------SWQDVQAYTVWLPY------QAIE----- 1178

Human  1064 MRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQ 1128
                                                     |:.|                    
  Fly  1179 -----------------------------------------PYNP-------------------- 1182

Human  1129 DPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA 1193
                                 .||...|....||                               
  Fly  1183 ---------------------FLTSNGSRKSSLE------------------------------- 1195

Human  1194 QLDVLPETFTLGD---KKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVT 1255
                 .|.||:|.   .|:..|:.|.||....:|:..:.|.    .|:.::..:.||..|..   
  Fly  1196 -----AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAF----TDEDKFTDTVYSSPITT--- 1248

Human  1256 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEM 1320
                 |..:.:.|...|.||:|:.::::.:....|.:....:||           ||...|.:..
  Fly  1249 -----ERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASK-----------LARMQDELAA 1297

Human  1321 RRLNYQTPGSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1384
            ....|.||               :.|:.:.|.:::...:.|:...:||:|:|.: ..|:......
  Fly  1298 LPEGYITP---------------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSF 1347

Human  1385 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1449
            :||..|:||||:.|::.|||||..|..:|...|||||||||:.|:.....:|.|||||..|..:|
  Fly  1348 ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEF 1412

Human  1450 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATYTVRTFALHKS 1513
            |||.||..:..:||:||..||.|.|||||||. |.....|.|:|.|:.......:::..|.:  |
  Fly  1413 WRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV--S 1475

Human  1514 GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1578
            .:.|.|.:|.|.|..|||.||||.|..::.|:|..:.....|..|::|||||||||:|.||.:|.
  Fly  1476 RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDR 1540

Human  1579 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG 1643
            :|:.:.....|||:|.|..||.:|.:|||||.|||.||:.|| |...|...:.|.:|..|..   
  Fly  1541 ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLELHAN--- 1601

Human  1644 QVPPGESVTAMELE 1657
               .|..||.:.||
  Fly  1602 ---DGYEVTKIYLE 1612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRFXP_005271136.1 I-set 33..124 CDD:400151 17/92 (18%)
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353 2/2 (100%)
Ig strand E 86..93 CDD:409353 1/6 (17%)
Ig strand F 104..109 CDD:409353 0/4 (0%)
Ig strand G 117..120 CDD:409353 2/2 (100%)
IgI_2_RPTP_IIa_LAR_like 136..226 CDD:409400 18/110 (16%)
Ig strand A 136..138 CDD:409400 0/4 (0%)
Ig strand A' 143..147 CDD:409400 0/3 (0%)
Ig strand B 150..159 CDD:409400 0/8 (0%)
Ig strand C 164..170 CDD:409400 1/5 (20%)
Ig strand C' 172..174 CDD:409400 0/1 (0%)
Ig strand D 183..187 CDD:409400 1/3 (33%)
Ig strand E 190..195 CDD:409400 1/4 (25%)
Ig strand F 204..211 CDD:409400 2/19 (11%)
Ig strand G 214..225 CDD:409400 2/10 (20%)
IgI_3_RPTP_IIa_LAR_like 239..320 CDD:409401 18/144 (13%)
Ig strand A 239..241 CDD:409401 0/1 (0%)
Ig strand A' 245..249 CDD:409401 0/13 (0%)
Ig strand B 252..260 CDD:409401 0/7 (0%)
Ig strand C 265..271 CDD:409401 2/31 (6%)
Ig strand C' 273..275 CDD:409401 0/1 (0%)
Ig strand D 278..282 CDD:409401 0/3 (0%)
Ig strand E 287..292 CDD:409401 2/6 (33%)
Ig strand F 299..306 CDD:409401 2/6 (33%)
Ig strand G 310..319 CDD:409401 0/8 (0%)
FN3 <311..716 CDD:442628 98/430 (23%)
FN3 714..820 CDD:238020 20/119 (17%)
FN3 825..914 CDD:238020 26/91 (29%)
FN3 923..1011 CDD:238020 16/91 (18%)
FN3 1020..>1079 CDD:238020 6/58 (10%)
R-PTPc-F-1 1350..1625 CDD:350474 118/276 (43%)
R-PTP-F-2 1627..1917 CDD:350477 8/31 (26%)
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628 33/178 (19%)
fn3 247..328 CDD:394996 18/94 (19%)
FN3 319..>749 CDD:442628 84/459 (18%)
fn3 708..796 CDD:394996 25/93 (27%)
fn3 902..978 CDD:394996 17/97 (18%)
fn3 1013..1092 CDD:394996 21/78 (27%)
PTP_tm 1127..1247 CDD:465889 37/313 (12%)
R3-PTPc 1358..1579 CDD:350396 101/222 (45%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.