DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRD and Ptp4E

DIOPT Version :9

Sequence 1:	NP_001364887.1	Gene:	PTPRD / 5789	HGNCID:	9668	Length:	1932	Species:	Homo sapiens
Sequence 2:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster

Alignment Length:	1743	Identity:	422/1743 - (24%)
Similarity:	665/1743 - (38%)	Gaps:	455/1743 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   151 GNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGT 215
            |.|:|..|       :..|:....||  .|.::.||.....|....|...:|..:    |.:..|
  Fly    98 GFPEPNTT-------IPASDIGKDIK--FSRALPGTEYNFWLYYTNSTHREQLTW----TVNITT 149

Human   216 RYSAPANLYVRELREVRRV-----PP---RFS-------------------------IPPTNHEI 247
            ....||||.| :||..:..     ||   |:|                         :..:..|:
  Fly   150 APDPPANLSV-QLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKEL 213

Human   248 MPGGSVNITCVAV------------------GSPMPYVKWMLGAEDLTP--EDDMPIG-----RN 287
            .||||..:...:|                  .:|..::.|......|..  :...|.|     |.
  Fly   214 TPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRV 278

Human   288 VLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPG------TPVVTESTATSI------- 339
            .:..:|..||..|    :...|.....||...|.|  .||      ...|:|...:|:
  Fly   279 SITPDDAIQSVLY----VEREGEPPGPAQAAFKGL--VPGREYNISVQTVSEDETSSVPTTARYL 337

Human   340 -------TLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDG----VATTR--YSVA----GLSPYS 387
                   .:|:|.......|:.:....|:.    |.|.|.    ::|:|  ::|.    |.|.|.
  Fly   338 TVPERVLNVTFDEAYTTSSSFRVRWEPPRT----YSEFDAYQVMLSTSRRIFNVPRAANGDSVYF 398

Human   388 DY--------EFRVVA---VNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLS------STTIL 435
            ||        .:.||.   .:|:...|.|..|..:         ||.|  |.|.      |..:.
  Fly   399 DYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLR---------PRPV--RSLGGFLDDRSNALH 452

Human   436 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN-------------VADSQIT------TIGN 481
            :.| ||.| .|:...||:.|             |.             .|:||||      |:.:
  Fly   453 ISW-EPAE-TGRQDSYRISY-------------HEQTNASEVPAPFPVAAESQITTNLTEYTLDS 502

Human   482 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIA- 545
            |:..:.|.:.|.|. |.|....:|||...|:   |..|| .:.....:..::|||   |||..:
  Fly   503 LLAGRRYLIAVQAL-SKGVASNASDITRYTR---PAAPL-IQELRSIDQGLMLSW---RSDVNSR 559

Human   546 --NYELVY-KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
              .||:.| ::|...|....|.|  ||..:..|.|.|.|..::.|.|             ..::|
  Fly   560 QDRYEVHYQRNGTREERTMATNE--TSLTIHYLHPGSGYEVKVHAIS-------------HGVRS 609

Human   608 KPSA--------PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKP-HEIL 663
            :|.:        |||:::..:..:..:::.||.|    :....:||.::|..    |..| ..|.
  Fly   610 EPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP----EGSDFSEYVVRYRT----DASPWQRIS 666

Human   664 GIPSDTTKYLLEQLEKWTEYRITV-TAHTDV-GPGPESLSVLIRTNEDVPSGPPRKVE--VEAVN 724
            |:..:..:  ::.:.....|.:.| |....| .|.|..|:|.:         ||:.|.  |..|:
  Fly   667 GLHENEAR--IKDMHYGERYLVQVNTVSFGVESPHPLELNVTM---------PPQPVSNVVPLVD 720

Human   725 STSVKVSWRSPVPNKQHGQIRGYQVHY---VRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI 786
            |.::.:.|..|     .|.:..|.:.:   ...:..|.|....|:|:.....:...:|
  Fly   721 SRNLTLEWPRP-----DGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIED------- 773

Human   787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVST-TGAVPGKPRLVIN----HTQMNTALIQWHP- 845
               |.|...|...|.|   ..:|.||....:|| |..:......:.|    ..|..|..:.:.|
  Fly   774 ---LSPGRQYRFEVQA---SSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPT 832

Human   846 PVDTFGPLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATDIHKGASY---VFRLSARNKVGFG 904
            |.|: .....||...|.   ||.|.|.    ::.|...:.:.:..|..|   |:.:|.    |..
  Fly   833 PADS-TRFDIYRFSMGDPTIKDKEKLA----NDTERKLSFSGLTPGKLYNVTVWTVSG----GVA 888

Human   905 EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY--RDINIPLLP 967
            ...|:.:.....:|.   .:|.:....:..:.|.|..|.     |..|.:.|.|  .|...|
  Fly   889 SLPVQRLYRLHPLPI---SDLKAIQVAAREITLHWTAPA-----GEYTDFELQYLSADEEAP--- 942

Human   968 MEQLI--VPADTTMTLTGLKP--DTTYDVKVRAHTSKG--------------PGPYSPSVQFRTL 1014
              ||:  |..:|.:||.||:|  :.|:.|.||:.:.:|              ..|.|.|.|..|.
  Fly   943 --QLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTA 1005

Human  1015 PVDQAVFAKNFHVKAVMKTSVLLSW--EIPENYNSAMPFKIL---YDDGKMVE--EVDGRATQKL 1072
            |..:..:   |....|....|...|  |..|.:.....|:|.   .||...|.  |....|||..
  Fly  1006 PPGKVDY---FQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGK 1067

Human  1073 IVNLKPEKSYSFVLTNRGNSAGGLQHR------VTAKTAPDVLRTKPAFIGKT------------ 1119
            |..|.|...|.|.:..:.....|.:..      :.|...|:...| |..:.:|
  Fly  1068 IDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVT-PLEVSRTSSTIEISFRQGY 1131

Human  1120 --NLDGMI---TVQLP----------EVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 1169
              |..||:   |:.:.          |:|:.::::. |.:.:|.:.     |:|:        :.
  Fly  1132 FSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQA-YTVWLPYQA-----IEPY--------NP 1182

Human  1170 LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1234
            .|.....::.|:.           |.||    |..|...|||..|:.|..|::|..|...:.|..
  Fly  1183 FLTSNGSRKSSLE-----------AEHF----TIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFT 1232

Human  1235 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI-------LLYK 1292
            :  |.|      ::|.|.|     .|||.|....:.|...|.||:.:..:::.:       |:.:
  Fly  1233 D--EDK------FTDTVYS-----SPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRR 1284

Human  1293 SSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPPI 1357
            :||..|.:.|    .:::|                            .||        :..:.|:
  Fly  1285 ASKLARMQDE----LAALP----------------------------EGY--------ITPNRPV 1309

Human  1358 PILELADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSA 1421
            .:.:.::|...:.|:.:.:||:|:|.: ..|:......:||..|:||||:.|::.|||||..|..
  Fly  1310 HVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQP 1374

Human  1422 IEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD 1486
            ::...||||:||||:.|:.....:|.|||.|..|..:||||.||..|..:||:|:..|:.|.|||
  Fly  1375 VDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD 1439

Human  1487 QYWP-SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTP 1550
            |||| .|....:|.::|.|:.......:.:..|.:.:|  .|.|.:|.|.||.|||.||||.|..
  Fly  1440 QYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQS 1502

Human  1551 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYM 1615
            .:.|:|..:.....|..|::|||||||||:|.||.:|.:|:.|.....|||:|.|..||.:|.:|
  Fly  1503 LVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFM 1567

Human  1616 VQTEDQYIFIHDALL------EAVTCGNTEVPARNLY----AYIQKLTQIETG 1658
            ||||.||:.||..||      |.:...:.|:.|.:.|    .|:::..|.:.|
  Fly  1568 VQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMG 1620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRD	NP_001364887.1	I-set	24..115	CDD:400151
		Ig strand A'	32..36	CDD:409353
		Ig strand B	39..48	CDD:409353
		Ig strand C	54..59	CDD:409353
		Ig strand C'	62..65	CDD:409353
		Ig strand D	68..75	CDD:409353
		Ig strand E	76..86	CDD:409353
		Ig strand F	94..102	CDD:409353
		Ig strand G	105..115	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	127..226	CDD:409400	19/74 (26%)
		Ig strand B	143..147	CDD:409400
		Ig strand C	156..160	CDD:409400	1/3 (33%)
		Interaction with IL1RAPL1. /evidence=ECO:0000250	180..189		3/8 (38%)
		Mini-exon peptide A9, sufficient for interaction with IL1RAPL1. /evidence=ECO:0000250\|UniProtKB:Q64487	181..189		2/7 (29%)
		Ig strand E	190..194	CDD:409400	1/3 (33%)
		Ig strand F	204..209	CDD:409400	0/4 (0%)
		Ig strand G	216..219	CDD:409400	0/2 (0%)
		Mini-exon peptide B, required for interaction with SLITRK2 and in the function in pre-synaptic differentiation, Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP, Modulates affinity for IL1RAPL1 and IL1RAP. /evidence=ECO:0000250\|UniProtKB:Q64487	227..230		1/2 (50%)
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401	20/130 (15%)
		Ig strand B	253..257	CDD:409401	0/3 (0%)
		Ig strand C	266..270	CDD:409401	0/3 (0%)
		Ig strand E	287..291	CDD:409401	0/3 (0%)
		Ig strand F	299..304	CDD:409401	1/4 (25%)
		Ig strand G	312..315	CDD:409401	0/2 (0%)
		FN3	323..412	CDD:238020	26/129 (20%)
		FN3	419..511	CDD:238020	30/116 (26%)
		FN3	516..604	CDD:238020	24/91 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..623		5/27 (19%)
		FN3	612..706	CDD:238020	21/96 (22%)
		FN3	713..819	CDD:238020	23/110 (21%)
		FN3	824..919	CDD:238020	20/105 (19%)
		FN3	922..1013	CDD:238020	28/110 (25%)
		FN3	1023..>1084	CDD:238020	19/67 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1304..1324		1/19 (5%)
		R-PTPc-D-1	1354..1637	CDD:350472	115/290 (40%)
		Substrate binding. /evidence=ECO:0000250	1573..1579		5/5 (100%)
		R-PTP-D-2	1638..1929	CDD:350476	6/25 (24%)
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	17/91 (19%)
		fn3	247..328	CDD:278470	19/86 (22%)
		fn3	343..417	CDD:278470	17/77 (22%)
		fn3	443..525	CDD:278470	22/97 (23%)
		FN3	548..611	CDD:238020	22/80 (28%)
		FN3	620..706	CDD:238020	20/95 (21%)
		fn3	708..796	CDD:278470	23/105 (22%)
		fn3	824..886	CDD:278470	16/70 (23%)
		fn3	902..978	CDD:278470	24/88 (27%)
		fn3	1013..1092	CDD:278470	21/78 (27%)
		UP_III_II	1106..>1248	CDD:297589	37/184 (20%)
		PTPc	1329..1582	CDD:214550	109/254 (43%)
		PTPc	1355..1582	CDD:238006	101/228 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940