DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRD and Ptprd

DIOPT Version :9

Sequence 1:	NP_001364887.1	Gene:	PTPRD / 5789	HGNCID:	9668	Length:	1932	Species:	Homo sapiens
Sequence 2:	XP_036019731.1	Gene:	Ptprd / 19266	MGIID:	97812	Length:	1966	Species:	Mus musculus

Alignment Length:	1959	Identity:	1885/1959 - (96%)
Similarity:	1910/1959 - (97%)	Gaps:	27/1959 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS 65
            ||.|||.|.|||||||...||||||||||||||||||||||||||||||||||||||||||||||
Mouse     8 MVPVARPLSLLLTFFLCACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS 72

Human    66 NQRFE-VIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTID 129
            ||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    73 NQRFEVVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTID 137

Human   130 MGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQI 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   138 MGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQI 202

Human   195 EQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   203 EQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 267

Human   260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPK 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   268 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPK 332

Human   325 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDY 389
            |||||||||||||||||||||||||||||||||||||||||.||||||:||||||||||||||||
Mouse   333 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDY 397

Human   390 EFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY 454
            ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   398 EFRVVAVNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY 462

Human   455 YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   463 YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 527

Human   520 LNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFR 584
            ||||||||||||||||||||||||||:|||||:||:.||||||||||||||||||||||||||||
Mouse   528 LNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFR 592

Human   585 LAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
            |:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
Mouse   593 LSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKY 657

Human   650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
            .||||||.|||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
Mouse   658 AAVDGEDFKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTDEDVPSGP 722

Human   715 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDD 779
            ||||||||||:|:|||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   723 PRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMENGEPKGQPMLKDVMLADAQWEFDD 787

Human   780 TTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWH 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   788 TTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWH 852

Human   845 PPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 909
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   853 PPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 917

Human   910 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP 974
            |||:|||:||||||||||||||||||||||||||||||||:||||||||||||:||||||.||||
Mouse   918 EISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLYRDINVPLLPMEHLIVP 982

Human   975 ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQAVFAKNFHVKAVMKTSVLLSW 1039
            |||:|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   983 ADTSMTLTGLKSDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQAVFAKNFHVKAVMKTSVLLSW 1047

Human  1040 EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1104
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1048 EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1112

Human  1105 APDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 1169
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse  1113 APDVLRTKPAFIGKTNLDGMITVQLPDVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDE 1177

Human  1170 LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1234
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1178 LLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1242

Human  1235 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRK 1299
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1243 DHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRK 1307

Human  1300 RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGSDDSGYP-----GNLHSSS--------- 1350
            ||||:|||||:||:||:|||||||||||||||||||....:..|     |::.|.|
Mouse  1308 RAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPALSSNSVPYASLIGSVSSLSSQTTTQSIY 1372

Human  1351 ------------MASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 1403
                        |||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1373 DNNSLPRFARKGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 1437

Human  1404 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1468
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1438 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1502

Human  1469 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1533
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1503 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1567

Human  1534 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT 1598
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1568 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT 1632

Human  1599 VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTG 1663
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1633 VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTG 1697

Human  1664 MELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGY 1728
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse  1698 MELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGY 1762

Human  1729 RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDP 1793
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1763 RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDP 1827

Human  1794 MAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1858
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1828 MAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1892

Human  1859 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY 1923
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
Mouse  1893 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEY 1957

Human  1924 LGSFDHYAT 1932
            |||||||||
Mouse  1958 LGSFDHYAT 1966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRD	NP_001364887.1	I-set	24..115	CDD:400151	90/91 (99%)
		Ig strand A'	32..36	CDD:409353	3/3 (100%)
		Ig strand B	39..48	CDD:409353	8/8 (100%)
		Ig strand C	54..59	CDD:409353	4/4 (100%)
		Ig strand C'	62..65	CDD:409353	2/2 (100%)
		Ig strand D	68..75	CDD:409353	6/7 (86%)
		Ig strand E	76..86	CDD:409353	9/9 (100%)
		Ig strand F	94..102	CDD:409353	7/7 (100%)
		Ig strand G	105..115	CDD:409353	9/9 (100%)
		IgI_2_RPTP_IIa_LAR_like	127..226	CDD:409400	98/98 (100%)
		Ig strand B	143..147	CDD:409400	3/3 (100%)
		Ig strand C	156..160	CDD:409400	3/3 (100%)
		Interaction with IL1RAPL1. /evidence=ECO:0000250	180..189		8/8 (100%)
		Mini-exon peptide A9, sufficient for interaction with IL1RAPL1. /evidence=ECO:0000250\|UniProtKB:Q64487	181..189		7/7 (100%)
		Ig strand E	190..194	CDD:409400	3/3 (100%)
		Ig strand F	204..209	CDD:409400	4/4 (100%)
		Ig strand G	216..219	CDD:409400	2/2 (100%)
		Mini-exon peptide B, required for interaction with SLITRK2 and in the function in pre-synaptic differentiation, Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP, Modulates affinity for IL1RAPL1 and IL1RAP. /evidence=ECO:0000250\|UniProtKB:Q64487	227..230		2/2 (100%)
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401	80/80 (100%)
		Ig strand B	253..257	CDD:409401	3/3 (100%)
		Ig strand C	266..270	CDD:409401	3/3 (100%)
		Ig strand E	287..291	CDD:409401	3/3 (100%)
		Ig strand F	299..304	CDD:409401	4/4 (100%)
		Ig strand G	312..315	CDD:409401	2/2 (100%)
		FN3	323..412	CDD:238020	85/88 (97%)
		FN3	419..511	CDD:238020	91/91 (100%)
		FN3	516..604	CDD:238020	82/87 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..623		19/19 (100%)
		FN3	612..706	CDD:238020	90/93 (97%)
		FN3	713..819	CDD:238020	102/105 (97%)
		FN3	824..919	CDD:238020	92/94 (98%)
		FN3	922..1013	CDD:238020	85/90 (94%)
		FN3	1023..>1084	CDD:238020	60/60 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1304..1324		15/19 (79%)
		R-PTPc-D-1	1354..1637	CDD:350472	282/282 (100%)
		Substrate binding. /evidence=ECO:0000250	1573..1579		5/5 (100%)
		R-PTP-D-2	1638..1929	CDD:350476	288/290 (99%)
Ptprd	XP_036019731.1	I-set	31..123	CDD:400151	90/91 (99%)
		Ig strand A'	39..43	CDD:409353	3/3 (100%)
		Ig strand B	46..55	CDD:409353	8/8 (100%)
		Ig strand C	61..66	CDD:409353	4/4 (100%)
		Ig strand C'	69..72	CDD:409353	2/2 (100%)
		Ig strand D	75..83	CDD:409353	6/7 (86%)
		Ig strand E	84..94	CDD:409353	9/9 (100%)
		Ig strand F	102..110	CDD:409353	7/7 (100%)
		Ig strand G	113..123	CDD:409353	9/9 (100%)
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400	98/98 (100%)
		Ig strand B	151..155	CDD:409400	3/3 (100%)
		Ig strand C	164..168	CDD:409400	3/3 (100%)
		Ig strand E	198..202	CDD:409400	3/3 (100%)
		Ig strand F	212..217	CDD:409400	4/4 (100%)
		Ig strand G	224..227	CDD:409400	2/2 (100%)
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401	80/80 (100%)
		Ig strand B	261..265	CDD:409401	3/3 (100%)
		Ig strand C	274..278	CDD:409401	3/3 (100%)
		Ig strand E	295..299	CDD:409401	3/3 (100%)
		Ig strand F	307..312	CDD:409401	4/4 (100%)
		Ig strand G	320..323	CDD:409401	2/2 (100%)
		FN3	331..420	CDD:238020	85/88 (97%)
		FN3	427..519	CDD:238020	91/91 (100%)
		FN3	524..612	CDD:238020	82/87 (94%)
		FN3	620..714	CDD:238020	90/93 (97%)
		FN3	721..827	CDD:238020	102/105 (97%)
		FN3	832..927	CDD:238020	92/94 (98%)
		FN3	930..1021	CDD:238020	85/90 (94%)
		FN3	1031..>1092	CDD:238020	60/60 (100%)
		R-PTPc-D-1	1388..1671	CDD:350472	282/282 (100%)
		R-PTP-D-2	1672..1963	CDD:350476	288/290 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83968663
Domainoid	1	1.000	746	1.000	Domainoid score	I3343
eggNOG	1	0.900	-	-		E2759_KOG4228
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	3800	1.000	Inparanoid score	I314
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47937
OrthoDB	1	1.010	-	-		D119609at33208
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		oto125106
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.300