DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRC and Lar

DIOPT Version :9

Sequence 1:	NP_002829.3	Gene:	PTPRC / 5788	HGNCID:	9666	Length:	1306	Species:	Homo sapiens
Sequence 2:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster

Alignment Length:	1711	Identity:	403/1711 - (23%)
Similarity:	629/1711 - (36%)	Gaps:	555/1711 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTMYLWLKLLAFGFAFLDTEVFV-----TGQSPTPSPTGLTT-------AKMPSVP-------LS 46
            :|||..::.|:   .:.:.|.:|     .|:.|..:|...||       .||.|.|       ||
  Fly   373 ITMYYVVRALS---PYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLS 434

Human    47 SDPLPTHTTAFSPASTFERE---NDFSETTTSLSP---------DN----TSTQVSPDSL--DNA 93
            |.   |....:.|..|...:   .....||.|..|         ||    |.::::|.::  ...
  Fly   435 SS---TMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRV 496

Human    94 SAFNTTGVSSVQTPHLPTHADSQTPS-----AGTD---------------------------TQT 126
            .|:.:.|...:.|| :...|....||     ..||                           ..|
  Fly   497 QAYTSMGAGPMSTP-VQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDT 560

Human   127 FSGSAANAKLNPTPGSNAISDVP-----------GERSTASTFPTDPV---------------SP 165
            ::..|.:.:::.:.........|           .:|...:|.|..||               :.
  Fly   561 YANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIAT 625

Human   166 LTTTLSLAHHSSAALPARTSN--------------------TTITANTSDAYLNASETTTLSPSG 210
            .:||:||   |....|...||                    ||:|.|.:...|:  |....:...
  Fly   626 SSTTISL---SWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLD--ELKRWTEYK 685

Human   211 SAVISTTTIATTP-SKPTCDEKYANITVDYLYNKETKLFTAKLNVNEN---VECGNNTCTNNEVH 271
            ..|::.|::...| |.|.......::..|....|.|.|.:..::|:..   .:..|.......:|
  Fly   686 IWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIH 750

Human   272 --------------------------NLTECK-NASVSISHNSCTAP---DKT--LILDVPPGVE 304
                                      |:|..: :...||...:.|..   |::  :::..|.||.
  Fly   751 AQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVP 815

Human   305 KFQLHDCTQVEKAD-TTICLKWKN-IETFTCDTQNITYRFQCG--------NMIFDNKEIK--LE 357
            .........:|:.. .:|.|:|:. .:|:   .:...||.:.|        .|:...:..|  .:
  Fly   816 VRPTVSLKIMEREPIVSIELEWERPAQTY---GELRGYRLRWGVKDQALKEEMLSGPQMTKKRFD 877

Human   358 NLEPEHEYKCDSEILYNNHKFTNAS--KIIKTDFGSP-GEPQIIFCRSEAAHQGVITWNPPQR-- 417
            |||...||  :..:..:||......  ||.:|..|:| |.|..|..|.:......:||:||.|
  Fly   878 NLERGVEY--EFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREH 940

Human   418 ----------SFH-----------NFTL-------------------CYIK------------ET 430
                      .||           |.||                   .|.|            ||
  Fly   941 RNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET 1005

Human   431 EKDC----LNLDK-------------------NLIKY--------------------------DL 446
            |:|.    ::|..                   .|:.|                          ||
  Fly  1006 ERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADL 1070

Human   447 QNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQV-----------------WNMTVS 494
            .||:.:.:|.:::.|..     :||...:....|....|..|                 |:..:.
  Fly  1071 VNLEKFAQYAVAIAARF-----KNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIR 1130

Human   495 MTSDN------------------------------SMHVKC------------------------ 505
            :|..|                              ..:||.
  Fly  1131 LTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYS 1195

Human   506 -RPP------------------------------------RDRNGPHERYHLEVEAGNTLVRNES 533
             |||                                    .:..||...|:|.|...:   ::..
  Fly  1196 YRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPED---KSNL 1257

Human   534 HKNCD-FRVKDL--------------------QYSTDYTFKA----YFHN--------------- 558
            ||..| |...||                    |.|..:||..    .:||
  Fly  1258 HKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIF 1322

Human   559 ---------------------------------------GDYPGEPFILHHSTSYNSKALIAFLA 584
                                                   .::|.||.:..:......:.|...|.
  Fly  1323 VRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLP 1387

Human   585 FL----IIVTSIALLVVLYKIYDLHKKRSCNLDEQ----QELVERD-----------DEKQLMNV 630
            .:    |:.|::.:|.|:.:     :::.|...:|    :.|:..|           |.::|...
  Fly  1388 LMVSTFIVSTALIVLCVVKR-----RRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQ 1447

Human   631 EP---IHADILLETYKRKI----ADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 688
            .|   .|..|.:..:...|    :::.:.|..|::|| ....:|....:....|::||||.::..
  Fly  1448 TPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTA 1511

Human   689 YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 753
            ||::||:|..:.|..||:||||:|.||:::...|:|.|||..||..|||||.||.|...|||:||
  Fly  1512 YDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTR 1576

Human   754 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK--KEKATGREVTHIQF 816
            .||..|.||.:|||:  .||..:|.:.|.|.:.:....|.|:...:..:  .::   ||:..:||
  Fly  1577 LEERTRIKCDQYWPT--RGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDR---REIKQLQF 1636

Human   817 TSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDV 881
            |:|||||||:.|...|:..||..|.:...|||::|||||||||||.||.||:|||.::.|..:|:
  Fly  1637 TAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDI 1701

Human   882 YGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEA 946
            ||:|..||.||..|||.|.|||.||.|::|....|.|||....||.:|..:...:|....|.:|.
  Fly  1702 YGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEV 1766

Human   947 EFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLK--HELEMSKESEHDSDESSDDD 1008
            ||::|.:.:...::.: .|...||.|||..:::||:.:||.|.  |.:
  Fly  1767 EFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGI----------------- 1814

Human  1009 SDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICA 1073
                |.|.|:|||||..|......||||||:::...|||:|:::....::||||:||...:|.|.
  Fly  1815 ----EGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCF 1875

Human  1074 QYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKEL 1137
            ||| .|....|....||.........|.||.|::..::...||||.|:|:.:|..:.:|...:..
  Fly  1876 QYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGF 1940

Human  1138 ISMI-QVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVV 1201
            |..| ||.|.|  ::...:|       |:.:||..|..::|:|..|..:||..:.|.|:|:||.|
  Fly  1941 IDFIGQVHKTK--EQFGQDG-------PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTV 1996

Human  1202 KALRKARPGMVSTFEQYQFLY 1222
            :.||..||.||.|.:||.|.|
  Fly  1997 RILRSQRPAMVQTEDQYHFCY 2017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRC	NP_002829.3	PTP_N	7..32	CDD:372119	5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..163		37/209 (18%)
		PHA03255	81..>231	CDD:165513	38/230 (17%)
		CD45	237..295	CDD:372194	13/92 (14%)
		FN3	392..462	CDD:238020	29/173 (17%)
		FN3	485..565	CDD:238020	28/266 (11%)
		R-PTPc-C-1	707..907	CDD:350405	97/201 (48%)
		Substrate binding. /evidence=ECO:0000250	853..859		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1014		0/20 (0%)
		R-PTP-C-2	1017..1223	CDD:350406	77/208 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1306
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470	8/33 (24%)
		FN3	423..514	CDD:238020	20/94 (21%)
		FN3	520..610	CDD:238020	12/89 (13%)
		FN3	616..707	CDD:238020	19/95 (20%)
		FN3	712..810	CDD:238020	13/97 (13%)
		FN3	832..907	CDD:238020	18/79 (23%)
		FN3	914..1005	CDD:238020	16/90 (18%)
		FN3	1012..1101	CDD:238020	12/93 (13%)
		fn3	1106..1198	CDD:278470	6/91 (7%)
		PTPc	1476..1731	CDD:214550	117/260 (45%)
		PTPc	1503..1731	CDD:238006	111/232 (48%)
		PTPc	1763..2022	CDD:214550	95/285 (33%)
		PTPc	1791..2022	CDD:238006	88/257 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810