DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRB and Ptp10D

DIOPT Version :9

Sequence 1:	XP_006719591.1	Gene:	PTPRB / 5787	HGNCID:	9665	Length:	2230	Species:	Homo sapiens
Sequence 2:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster

Alignment Length:	1883	Identity:	526/1883 - (27%)
Similarity:	793/1883 - (42%)	Gaps:	465/1883 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   483 LYNLTVMTEAAGLQ------NYRW------------KLVRTAPMEVS--NLKVTNDGSLTSLKVK 527
            ||.|:..|....|:      .:||            |.||.|.:.:|  |....:||:  |.::.
  Fly     2 LYQLSKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGA--SYRLD 64

Human   528 WQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQ-----------------VT 575
            :. ||......|.|::       ||.:.   .|..|...:||..|.                 ||
  Fly    65 YS-PPFGYPEPNTTIA-------SREIG---DEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVT 118

Human   576 VSCVSGELSAQKMAVGRTFPDKVANLEAN-NNGRMRSLVVSWSPPA-GDWEQYRILLFNDSVVLL 638
            ::               |.||..:||... .:|  ::.::.||||. |.:..::|.:..    |.
  Fly   119 IT---------------TAPDPPSNLSVQVRSG--KNAIILWSPPTQGSYTAFKIKVLG----LS 162

Human   639 NITVGKEETQYVMDDT------GLVPGRQYEVE----------VIVESGNLKNSERCQGRTVPLA 687
            ..:.....|..|.|:|      .|.||..|:|:          |...|.|........|:.:
  Fly   163 EASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFI--- 224

Human   688 VLQLRVKHANETSLSIMWQT--PVAEWEKYIISL----ADRDLLLIHKSLSKDA-KEFTFTDLVP 745
                 |...|||:|.::||.  |...:..|.:|:    |:..:|.:.|...... .:..|..|||
  Fly   225 -----VWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVP 284

Human   746 GRKYMATVTSISGD-LKNSSSVKGRTVPAQVTDLHVANQGMTSSLF-TNWTQAQGDVEF--YQVL 806
            ||.|..:|.::|.| :...::.:.||||.:..::......:||:.| ..|...:|..||  |||.
  Fly   285 GRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVS 349

Human   807 LI----HENVVIKNESISSETSRYSFHSL-KSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSG 866
            :.    ...|...||.::.    :.|..: :.|..::|:|.||||.::|.....:....|..|..
  Fly   350 VATTRRQSTVPRSNEPVAF----FDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRN 410

Human   867 VTVNNSGRNDYLSVSWLLAPGDV-DNYEV------TLSHDGKVVQSLVIAKSVRECSFSSLTPGR 924
            :...|..:.:.:.::|...|... |.|.:      |.:.|
  Fly   411 LRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGD------------------------- 450

Human   925 LYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNN 989
              |.|:||                                             |....|:::
  Fly   451 --TSTLTT---------------------------------------------DRTRFTLES--- 465

Human   990 FIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQG------NGRTIPEPVKDLTLRNR 1048
                              |:|||.||::|...|.:.|:||..      ....|.|.:|.:.:
  Fly   466 ------------------LLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRM--- 509

Human  1049 STEDLHVTW-SGANGDVDQYEIQLLFN---DMKVFPPFHLVNTATEYRFT--SLTPGRQYKILVL 1107
               .|:::| |..|...:|||:....|   |::       .....|.|..  :|.||..|::.|.
  Fly   510 ---GLNISWKSDVNSKQEQYEVLYSRNGTSDLR-------TQKTKESRLVIKNLQPGAGYELKVF 564

Human  1108 TISGDVQQS--AFIEGFTVPSAVKNIHISPNGATDSLTVNWT-PGGGDVDSYTVSAFRHSQKVDS 1169
            .:|.|::..  |:.:. ..|:..:|:.|. ...::|:.|:|: |..|:...|::     ..:.||
  Fly   565 AVSHDLRSEPHAYFQA-VYPNPPRNMTIE-TVRSNSVLVHWSPPESGEFTEYSI-----RYRTDS 622

Human  1170 QTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSW 1234
                              ||..:.:.||
  Fly   623 ------------------EQQWVRLPSV------------------------------------- 632

Human  1235 QKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEG 1299
                                  |:|....|       |:|.|:||.||:.|||.|:.|...|...
  Fly   633 ----------------------RSTEADIT-------DMTKGEKYTIQVNTVSFGVESPVPQEVN 668

Human  1300 RTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDG-------NLQERAQVDPL-VQS 1356
            .|||.......|....:|:::..|...||.:..|.:..:..|.       |:.|....|.| ...
  Fly   669 TTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVR 733

Human  1357 FSFQNLLQGRMYKMVIVTHS-GELSNESFIFGRTVP---ASVSHLRGSNRNTTDSLWFNWSP--- 1414
            .....|:.|..||..|.|.| |.||..:.::.||:|   :.|....|...:..|::..:::|
  Fly   734 VLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQ 798

Human  1415 ASGDFDFYELILYNPNGTKKE---NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSN-KVTAES 1475
            :|..||.|...|.:.....||   |..|:.:|   |.||||||.|.:.|.|.||.::: .:..:.
  Fly   799 SSSKFDIYRFSLGDAEIRDKEKLANDTDRKVT---FTGLVPGRLYNITVWTVSGGVASLPIQRQD 860

Human  1476 RTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-VYG 1539
            |..|.|.:.:...:|.:|.:::.|..|..  :||||::.:|..|.|..    .|..:...| :..
  Fly   861 RLYPEPITQLHATNITDTEISLRWDLPKG--EYNDFDIAYLTADNLLA----QNMTTRNEITISD 919

Human  1540 LRPGRSYQFNVKTVSG--DSWKTYSKPIFGSVRTK---PDKIQNLHCRPQNSTAIACSWIPPDSD 1599
            |||.|:|.|.|...||  .|....|.|:..|..|.   |.:::..|......:.|...|..|.|:
  Fly   920 LRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSE 984

Human  1600 FDG----YSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA-GMTSEVVEDST 1659
            .:|    :||....::.......:..|.|::...|..|.|.:.|:..|:.::| |...|.....|
  Fly   985 ANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQT 1049

Human  1660 ITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQ 1724
            :.::   .||.|..:|...:|..|.|:|......::|||.||.|:.:|::|.|    |:.|....
  Fly  1050 MPIL---APPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAE----DDAKNASG 1107

Human  1725 HPLPSYLEYRHNASIRVYQT--NYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDG 1787
            ..:||:|:.:..:....||.  .|:       |..|....:..:|.|      .||..:..:|:|
  Fly  1108 LEMPSWLDVQSYSVWLPYQAIDPYY-------PFENRSVEDFTIGTE------NCDNHKIGYCNG 1159

Human  1788 PLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLV 1852
            |||..|.||:.:||||     ...:||     ||.:|.||.|:.:.. ..|..::..|.:|  ||
  Fly  1160 PLKSGTTYRVKVRAFT-----GADKFT-----DTAYSFPIQTDQDNT-SLIVAITVPLTII--LV 1211

Human  1853 AVVALLI-------CRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHF 1910
            .:|.||.       ||:.....|...:..|      |.||     .:.||    ||.|..|..|:
  Fly  1212 LLVTLLFYKRRRNNCRKTTKDSRANDNMSL------PDSV-----IEQNR----PILIKNFAEHY 1261

Human  1911 MKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY 1975
            ..:.|||::..|:|:||||.|||:|.|..|.||.||.|||:.||||||.:|.||..||||..|||
  Fly  1262 RLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDY 1326

Human  1976 INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS 2040
            |||:|:||:|..||:|||||||..|:||||:|.||.|...|||:|:|.||||.|||.|||.|...
  Fly  1327 INANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP 1391

Human  2041 LYYGDLILQMLSESVLPEWTIREFKIC-GEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRT 2104
            ::|||:.:|:|::|...:|.:.||.:| |.||    |::||||:|.|||.|||...|:|::|||.
  Fly  1392 VFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ----RILRHFHFTTWPDFGVPNPPQTLVRFVRA 1452

Human  2105 VRDYINRSPGA--GPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQT 2167
            .||.|    ||  .|.||||||||||:||||.|||||||:::.|.|||:|.|:.:|..||.||||
  Fly  1453 FRDRI----GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQT 1513

Human  2168 ECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRG----------------GHLLH 2214
            |.||:.:|||:..||..:      ||.:.|..|..:.|.:.|                |||.|
  Fly  1514 EQQYICIHQCLLAVLEGK------ENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSH 1570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRB	XP_006719591.1	RICIN	<22..94	CDD:238092
		fn3	255..319	CDD:278470
		fn3	331..407	CDD:278470
		fn3	422..488	CDD:278470	3/4 (75%)
		FN3	507..582	CDD:238020	18/93 (19%)
		fn3	596..672	CDD:278470	22/93 (24%)
		fn3	687..765	CDD:278470	23/85 (27%)
		fn3	774..847	CDD:278470	20/80 (25%)
		fn3	862..938	CDD:278470	12/82 (15%)
		fn3	950..1026	CDD:278470	10/75 (13%)
		fn3	1039..1112	CDD:278470	18/78 (23%)
		fn3	1126..1199	CDD:278470	14/73 (19%)
		fn3	1216..1294	CDD:278470	15/77 (19%)
		fn3	1305..1378	CDD:278470	18/81 (22%)
		fn3	1394..1466	CDD:278470	25/77 (32%)
		fn3	1480..1562	CDD:278470	24/84 (29%)
		fn3	1574..1649	CDD:278470	16/79 (20%)
		PTPc	1920..2178	CDD:214550	151/260 (58%)
		PTPc	1947..2178	CDD:238006	135/233 (58%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	20/86 (23%)
		fn3	220..304	CDD:278470	24/91 (26%)
		fn3	315..391	CDD:278470	20/79 (25%)
		FN3	405..494	CDD:238020	26/181 (14%)
		FN3	511..574	CDD:238020	18/69 (26%)
		FN3	583..671	CDD:238020	31/177 (18%)
		fn3	683..753	CDD:278470	16/69 (23%)
		fn3	787..850	CDD:278470	23/65 (35%)
		fn3	866..935	CDD:278470	21/74 (28%)
		fn3	961..1043	CDD:278470	17/81 (21%)
		PTPc	1272..1525	CDD:214550	152/260 (58%)
		PTPc	1298..1525	CDD:238006	136/234 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1621
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2125
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1112
Isobase	1	0.950	-	0	Normalized mean entropy	S5167
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm40832
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710