DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF410 and pho

DIOPT Version :9

Sequence 1:	NP_001229853.1	Gene:	ZNF410 / 57862	HGNCID:	20144	Length:	516	Species:	Homo sapiens
Sequence 2:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	101/375 - (26%)
Similarity:	160/375 - (42%)	Gaps:	94/375 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    68 SGCSDLNDTTNHSNSSKEVPSSAVLRSLRVNVGPDGEETRAQTVQKSPEFLSTSESSSLLQDLQP 132
            ||.||    ..:|.|.:.|.:|.:|:. :...|.||     .|.|::.|:.......:..|.|:.
  Fly   169 SGISD----DEYSGSDQIVGASDLLKG-KEEFGIDG-----FTSQQNKEYQKMESKFTNAQTLEM 223

Human   133 SDSTSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSES---------TDSSIPWFLRVQEL 188
            ....|.:.:          .:||:      ::.||  ||.|:         |..|....:.:.:.
  Fly   224 PHPISSVQI----------MDHLI------KERGN--LSQENNISERILSKTTLSFEEPILLPDS 270

Human   189 AHDSLIAATRAQLAKNAKTSSNGE----NVH---------LGSGDGQSKD--------------- 225
            :...|:..|.|....|.:|.||..    ::|         :|..:||..|
  Fly   271 SSIELVNETAAMTINNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTD 335

Human   226 -SG----PLPQV------EKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYV 279
             :|    .|.:|      :||:.|..:||::.|...:..:.||.|| ..|..:| || |||:|..
  Fly   336 STGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTH-GPRVHVC-AE-CGKAFVE 397

Human   280 LQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLR 344
            ..:||.|...|.|||||.|...||||:|:...||:.|.|||||::||:|....|.:.||:.::|:
  Fly   398 SSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLK 462

Human   345 KHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQLGAAGSQEQEQTA 394
            .|::.|:..| ....:.||    ||..|..          :.||.::.:|
  Fly   463 SHILTHAKAK-RNTSISGK----SGCSNAE----------SNSQSEDTSA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF410	NP_001229853.1	zf-C2H2_8	268..351	CDD:292531	38/82 (46%)
		C2H2 Zn finger	271..290	CDD:275370	8/18 (44%)
		zf-H2C2_2	283..309	CDD:290200	15/25 (60%)
		C2H2 Zn finger	298..320	CDD:275368	10/21 (48%)
		zf-H2C2_2	312..338	CDD:290200	12/25 (48%)
		C2H2 Zn finger	328..350	CDD:275368	6/21 (29%)
		zf-H2C2_2	342..367	CDD:290200	6/24 (25%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	12/40 (30%)
		C2H2 Zn finger	359..381	CDD:275368	6/21 (29%)
		COG5048	<386..515	CDD:227381	48/129 (37%)
		zf-C2H2	386..408	CDD:278523	10/23 (43%)
		C2H2 Zn finger	388..408	CDD:275368	10/21 (48%)
		zf-H2C2_2	401..426	CDD:290200	14/24 (58%)
		C2H2 Zn finger	416..438	CDD:275368	10/21 (48%)
		zf-H2C2_2	430..457	CDD:290200	13/26 (50%)
		C2H2 Zn finger	446..468	CDD:275368	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910