DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF410 and lmd

DIOPT Version :9

Sequence 1:	NP_001229853.1	Gene:	ZNF410 / 57862	HGNCID:	20144	Length:	516	Species:	Homo sapiens
Sequence 2:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	127/590 - (21%)
Similarity:	203/590 - (34%)	Gaps:	193/590 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    30 ESEAKDITCLSLLPVTEASECSRLMLPEPVP------------WREEDGKSGCSDLNDTTNHSNS 82
            |.:.|:....:.||    |..|....|:.:|            :::..|.|       |.|:.|:
  Fly   251 EEQVKEEASPAKLP----SMNSTFGTPKCIPMCASNYEDYANLYQQGSGYS-------TENYHNN 304

Human    83 SKEVPSSAVLRSLRVNVGPDGEETRAQTVQKSPEFLSTSESSSLLQDLQPSDSTSFILLNLTRAG 147
            ..:|...           |:.|.....|:.:             |.:|...:...|:..:|.:..
  Fly   305 MAQVVEK-----------PNREHKAIWTIDE-------------LDELMLGEQQQFLQHHLQQQH 345

Human   148 LGSSAEHLVFVQDEAEDSGN------DFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAK 206
            |....|.|.....:.:.:.|      ::||.|        |::.:|.               .:.
  Fly   346 LQEQQEQLHQPHGQEQQTQNCKDDLVNYLSDE--------FIKAEEF---------------RSL 387

Human   207 TSSNGENVHLGSGD------GQSKDSGPL-------PQVEKK-----LKCTVEGCDRTFVWPAHF 253
            .|.:.||.:....|      ....:|.|.       |:.|.:     |.|...|||..|.....|
  Fly   388 DSDDDENYNEEEDDLDNDVFAPPAESDPKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAF 452

Human   254 KYHL-KTH---RNDRSFICPAEGCG---KSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAG 311
            ..|: |.|   |....|.|....|.   |.|....:|.:|||.|:||||..|...||.|.|:...
  Fly   453 VEHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLE 517

Human   312 NLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQV--CGKTFSQSGSRNVH 374
            |||.|:|.||||:|:.|:.:||.::|:..|...||...|...||:.||:  |.|.::...|...|
  Fly   518 NLKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQRTHYDTKPYACQLPGCTKRYTDPSSLRKH 582

Human   375 MRKHHLQLGAAGSQEQEQTA----EPLMG------------SSLLEE-------ASVPS------ 410
            ::.|.|:  .|..|.:.::|    .|..|            |:|::.       .:|||
  Fly   583 VKNHALR--NANGQLRRKSAGGASVPPSGPKKAAKTRRHSESALVQRGVGAGVGVAVPSAPGDQR 645

Human   411 ---KNLVS-------------------MNSQP---------------SLGGESLNLPNTNSILGV 438
               .|..|                   ...||               :....|:|....::.:.:
  Fly   646 QHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNNSMNFNELSNCIVI 710

Human   439 DDEVLAEG--SPRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQESLAPLPRLE----CSGAF 497
            .:...:.|  .|.:|::....|....|..:|                ::||.|..|    |||..
  Fly   711 IEHNQSGGPAGPATLATATATTTATATYGNG----------------NMAPAPETEVLSVCSGGG 759

Human   498 SAHCN 502
            |::.|
  Fly   760 SSNSN 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF410	NP_001229853.1	zf-C2H2_8	268..351	CDD:292531	35/85 (41%)
		C2H2 Zn finger	271..290	CDD:275370	7/21 (33%)
		zf-H2C2_2	283..309	CDD:290200	14/25 (56%)
		C2H2 Zn finger	298..320	CDD:275368	10/21 (48%)
		zf-H2C2_2	312..338	CDD:290200	13/25 (52%)
		C2H2 Zn finger	328..350	CDD:275368	7/21 (33%)
		zf-H2C2_2	342..367	CDD:290200	9/26 (35%)
		C2H2 Zn finger	358..378	CDD:275368	6/21 (29%)
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	14/25 (56%)
		C2H2 Zn finger	504..526	CDD:275368	10/21 (48%)
		C2H2 Zn finger	534..556	CDD:275368	7/21 (33%)
		C2H2 Zn finger	564..586	CDD:275368	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910