Protein Alignment PTPRA and csw

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 825
• Identity: 190/825 - (23%)
• Similarity: 307/825 - (37%)
• Gaps: 256/825 - (31%)

Human    50 TAEPVKEEAKTSNPTSSLTSLSVAPTFSPNIT------LGPTYLTTVNSSDSDNGTTRTASTNSI 108
            :|:| ...|..|..|.||..|:.:|..|...|      ..|.:......:...|.|....:|
  Fly   141 SAQP-SAAASASTSTESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGASCSNSTLSLLAT--- 201

Human   109 GITISPNG-TWLPDNQFTDARTEPW---EGNSST-----AATTPETFPPSGNSDSKDRRDETPII 164
             :.:..:| ||...| .:....|..   .|.:.:     :.:.|..|..|..:|.|
  Fly   202 -MRVQLHGYTWFHGN-LSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDK--------- 255

Human   165 AVMVALSSLLVIVFIIIVLYMLRF--KKYKQAGSHSNSFRLSN-----GRTEDVEPQSVPLLARS 222
                            :...|:|:  |||...|..|.. .||.     .|...||.....:..|.
  Fly   256 ----------------VTHVMIRWQDKKYDVGGGESFG-TLSELIDHYKRNPMVETCGTVVHLRQ 303

Human   223 PSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAAS-----KEENKEKNRY 282
            |....:.....::...|::.:..      |.|||.:|.    |.:.:..|     |:||:.||||
  Fly   304 PFNATRITAAGINARVEQLVKGG------FWEEFESLQ----QDSRDTFSRNEGYKQENRLKNRY 358

Human   283 VNILPYDHSRVHLTPVE-GVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 346
            .|||||||:||.|..|| .|..::||||::|               :..|..|.:.|    ::::
  Fly   359 RNILPYDHTRVKLLDVEHSVAGAEYINANYI---------------RLPTDGDLYNM----SSSS 404

Human   347 IVMVTNLKERKECKCAQYWPD-QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRL 410
            ..:.:::.....|..||...: ..|.......|.....:.::.|:....|.::...::..|.
  Fly   405 ESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKR--- 466

Human   411 ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHT 475
             ::...:|.|..|                             ..:|.|.:||
  Fly   467 -SESSASSSPSSG-----------------------------SGSGPGSSGT------------- 488

Human   476 ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTS 540
                   ..||.:..                                              |||.
  Fly   489 -------SGVSSVNG----------------------------------------------PGTP 500

Human   541 NNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFI 605
            .|        |||       ...|.|...:|::                   ..:::..|:.|..
  Fly   501 TN--------LTS-------GTAGCLVGLLKRH-------------------SNDSSGAVSISMA 531

Human   606 DGYRQKD-----SYIASQGPLL----HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD 661
            :..|:::     :|||:||.||    :|:.|||.|:|:..:..|||.|:..|||:||||:|||.:
  Fly   532 EREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE 596

Human   662 G-LVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIA 725
            | ...:|...::...|.....||:|:.|| :.|:..:|:|..:||..||:.|:|:|...:::.:.
  Fly   597 GRSEQFGHARIQCVSENSTSDYTLREFLV-SWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQ 660

Human   726 AVQKQQQ---QSGNH--PITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQR 782
            .|..:|.   |:|..  ||.||||||.||||||..:..:|:::...|:   :|:.:|::.:|.||
  Fly   661 DVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQR 725

Human   783 PHMVQTLEQYEFCYKVVQEYIDAF--------------SDYANFK 813
            ..:|||..||:|.|..||.||...              .:|.|.|
  Fly   726 SGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIK 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	53/301 (18%)
		R-PTPc-A-2	574..801	CDD:350471	81/244 (33%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	23/122 (19%)
		PTPc-N11_6	352..748	CDD:350392	137/548 (25%)