Protein Alignment PTPRA and Ptp99A

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 781
• Identity: 248/781 - (31%)
• Similarity: 390/781 - (49%)
• Gaps: 99/781 - (12%)

Human    43 TRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNS 107
            |||....|...::..|       |...|..|.... |:|....|...|           .|:|.|
  Fly   479 TRLAGQDTHRDIRINA-------SAKELETAMILQ-NLTTNSYYEVKV-----------AAATFS 524

Human   108 IGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVA-LS 171
            :   |:|....|  .:|:::|....:.|.       |...|.......|..     :||:|. :.
  Fly   525 V---INPKKIVL--GKFSESRIIQLQPNC-------EKLQPLLRQSHNDYN-----LAVLVGIIF 572

Human   172 SLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYP------ 230
            |...|:.||:..::...|.:     |:..:.|.       :|...|   .:|..:.:.|
  Fly   573 SCFGIILIIMAFFLWSRKCF-----HAAYYYLD-------DPPHHP---NAPQVDWEVPVKIGDE 622

Human   231 ---PLPVDKLEEEINRRMADDNKLFREEFNA---------LPACPIQATCEAASKEENKEKNRYV 283
               .:||::..:.:....||.:..|..|:.|         ||       ||.:...|||.||||:
  Fly   623 IRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLP-------CEHSQHPENKRKNRYL 680

Human   284 NILPYDHSRVHLTPVEGVPDS-DYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 347
            ||..||||||||.|..|...: |||||:||:|||:.:.||..|||..:|.:.||||||||..|.|
  Fly   681 NITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAII 745

Human   348 VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRK---PQR 409
            ||:|||.||...||..|||..|..|||.|:|.:.:..|:..||||...|:.: .:..:|   .::
  Fly   746 VMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHL-KLKKKKQCNTEK 809

Human   410 LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMH 474
            |:.|:|:|:|||.|.|..|:.:|.|:||..|.||..||.||||||||||||||::|:||||..:.
  Fly   810 LVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQ 874

Human   475 TERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGT 539
            .:..|:|:||:..|||||..:|||:.||:|::.||:|....|:|.|    :...::::.|..|
  Fly   875 QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL----MAEQVEELKNCTP-- 933

Human   540 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASF 604
               .||:::|.:...:.::..:.:.....|..|||. .|.|.|.:||.:..|.||:.:||:|||:
  Fly   934 ---YLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASW 994

Human   605 IDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGD- 668
            :.|:|:...:|.:|.|:.|||:|||:|:|:..:.::|:|:.|::   ...||:||.:......|
  Fly   995 LHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDEATPIESDH 1056

Human   669 ITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ 733
            ..|:...:.....|..||.::.:.:::....::..|...|||:..|:   .:...|..|.::...
  Fly  1057 YRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCND 1118

Human   734 SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV 798
            ..|.||.:....|..:..||||:|::...::.....:|:|..|....:||.:..:.|.....|.:
  Fly  1119 YRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI 1183

Human   799 V 799
            :
  Fly  1184 L 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	140/316 (44%)
		R-PTPc-A-2	574..801	CDD:350471	62/227 (27%)
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020
		fn3	343..430	CDD:394996
		FN3	442..520	CDD:238020	12/59 (20%)
		R5-PTPc-1	704..907	CDD:350397	103/203 (51%)
		R5-PTP-2	989..1182	CDD:350398	51/198 (26%)