Protein Alignment PTPRA and Ptp69D

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 936
• Identity: 284/936 - (30%)
• Similarity: 439/936 - (46%)
• Gaps: 163/936 - (17%)

Human     3 DAVQIT---KISMDSWFILVLL------GSGLIC------VSANNATTVAP-------------- 38
            ||:..|   |:::||.::|.|.      .:|.||      |..||.....|
  Fly   546 DAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVH 610

Human    39 -------SVGITRLINSSTAEP-----------------------------------------VK 55
                   |..|..:|:|....|                                         :.
  Fly   611 SDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIP 675

Human    56 EEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLP 120
            .:...||..|.|..||..........|....|..:.|...|.....|:..|.|...::||   :|
  Fly   676 PQGSLSNSDSELPILSEKDNLIKGANLTEHALKILESKLRDKRNAVTSDENPILSAVNPN---VP 737

Human   121 DNQFTDARTEPWEG----NSS--------------------------TAATTPETFPPSGNSDSK 155
               ..|:..:.::|    ||:                          |.||..|......|.|.
  Fly   738 ---LHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDY- 798

Human   156 DRRDETPIIAVMVALSSLLV-IVFIIIVLYMLRFKKYKQ--AGSHSNSFRLSNGRTEDVEPQSVP 217
                   .:::.|...::|: ::.:.|||::...||.|.  .|..:.:.|.|..|.
  Fly   799 -------YLSIGVKAGAVLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRA--------- 847

Human   218 LLARS--------PSTNRK-YPPLPVDK--LEEEINRRMADDNKLFREEFNALPACPIQATCEAA 271
            |..|.        .|.|.| :...|:.:  ||.....|..|.:..|..|:..||......|.:.:
  Fly   848 LFGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNS 912

Human   272 SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW 336
            ..:||..||||.:|..||.:||.|..:.|:..:|||||:|:.||:|:.|||.||||.|.|::|||
  Fly   913 DLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFW 977

Human   337 RMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT--YGNIRVSVEDVTVLVDYTVRKFCIQQ- 398
            ||||||:...|||:|||:|..:.|||:|||::...|  :|:|.|.........||..|...:.:
  Fly   978 RMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKN 1042

Human   399 ---VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRT 460
               ||:..:|   |.|||:|:.:|.||..|..|.|::||::::.:......|.|:||||||||||
  Fly  1043 KANVGEEEDR---RQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRT 1104

Human   461 GTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL 525
            ||.|.:|:::..:..|..|.:|..|..:|.||..:||:..||:|:|:|||:...:|:|::.:.::
  Fly  1105 GTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTM 1169

Human   526 ETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK-MRTGNLPANMKKNRVLQIIPYEFNRVIIP 589
            .:.::.:..| |......||.||:||.:...:..| ...|....|..|||..:||||:.||||:.
  Fly  1170 ASAIESLKRK-PNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILT 1233

Human   590 VKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKC 654
            .....||:.|:|||||:||...:::|.:|.||.:||.||||||.|....::||::|:.: |..||
  Fly  1234 PLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKC 1297

Human   655 AQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVG--IPSDG 717
            .:|| :|..|.|..|.|:....|.|..||.|:..|||.:.:.:.::.||.::|||.|.  :|...
  Fly  1298 PRYW-ADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVC 1361

Human   718 KGMISIIAAV---QKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSL 778
            :|:|.::...   .|..:.|| ..|:|||||.|..|:..|.|:..:::.::.|..:|:..|.:.|
  Fly  1362 RGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKL 1426

Human   779 RLQRPHMVQTLEQYEFCYKVVQEYID 804
            |.||..::.:..||||.::.:..|.|
  Fly  1427 RSQRTGLINSYAQYEFLHRAIINYSD 1452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	122/303 (40%)
		R-PTPc-A-2	574..801	CDD:350471	86/232 (37%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046
		fn3	237..321	CDD:394996
		FN3	<300..>524	CDD:442628
		PTPc	892..1155	CDD:214550	112/265 (42%)
		PTPc	1186..1449	CDD:214550	97/264 (37%)