Protein Alignment PTPRA and Lar

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 305/678 - (44%)
• Similarity: 421/678 - (62%)
• Gaps: 45/678 - (6%)

Human   158 RDETPIIAVMVAL--SSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLA 220
            :||..|:.|::.|  |:.:|...:|::..:.|              |....:|.|....:.||:|
  Fly  1376 KDEPEILWVVLPLMVSTFIVSTALIVLCVVKR--------------RRQPCKTPDQAAVTRPLMA 1426

Human   221 ---------RSPSTNRK----------YPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQA 266
                     ..|...|:          :||:|:.:....|.|..::||:.|.:|:.::.... |.
  Fly  1427 ADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQ-QF 1490

Human   267 TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 331
            |.:.::.|.||.||||.|:..||||||.|..||||..||||||::.:||::.|.::|.|||.:||
  Fly  1491 TWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET 1555

Human   332 VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKF-- 394
            ..|||||.||..||||||:|.|:||...||.||||.:|..|||.|.|::.:...|..|::|.|
  Fly  1556 FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQL 1620

Human   395 CIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGR 459
            |.|...|      :|.|.|..||:|||.|||..|...|:||::.:|..|..:|.::|||||||||
  Fly  1621 CRQGFND------RREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGR 1679

Human   460 TGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 524
            ||.::|||:||:.|..|:.:|:||.|:.:||||..||||:.||:||:.|:||..:.|.||:...:
  Fly  1680 TGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARN 1744

Human   525 LETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIP 589
            |.|||||:....||.:.:|:|.|||||:::|:.:.|..|.|||.|..|||::.|:|||.:||.:.
  Fly  1745 LHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLT 1809

Human   590 VKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKC 654
            ...|.|.:||||||||||||.:.:|||:|||:....||||||:||..|..:||||:|:|.|:|||
  Fly  1810 PIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKC 1874

Human   655 AQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKG 719
            .||||.:..|.|....|:...|.....|.:|:..||:.|:..||.:|||.|..|||.|:|..|:|
  Fly  1875 FQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEG 1939

Human   720 MISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRP 783
            .|..|..|.|.::|.| :.|||||||||.||:|.|..||.||||::.||:|||||||:.||.|||
  Fly  1940 FIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRP 2004

Human   784 HMVQTLEQYEFCYKVVQEYIDAFSDYAN 811
            .||||.:||.|||:...||:.:|.:|.|
  Fly  2005 AMVQTEDQYHFCYRAALEYLGSFDNYTN 2032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	139/306 (45%)
		R-PTPc-A-2	574..801	CDD:350471	120/227 (53%)
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	125/242 (52%)
		R-PTP-LAR-2	1784..2021	CDD:350402	126/236 (53%)