DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRA and Ptp36E

DIOPT Version :9

Sequence 1:	NP_001372231.1	Gene:	PTPRA / 5786	HGNCID:	9664	Length:	813	Species:	Homo sapiens
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	682	Identity:	195/682 - (28%)
Similarity:	341/682 - (50%)	Gaps:	94/682 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   193 QAGSHSNSFRLSNGRTEDVEPQ--------SVP-------------------LLAR--SPSTNRK 228
            :.|.|.:.   |:.|.:|||.|        |:|                   |.||  :.|.::.
  Fly    16 KTGKHRSR---SSARYDDVEKQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKT 77

Human   229 YPPLPVD-----KLEEEINRRMADDNKLFREEFNALPACPIQA-TCEAASKEENKEKNRYVNILP 287
            .|..|:|     || .::.|:..   .|::.||..  |..::: ||..|.|:.|.|||:....:|
  Fly    78 IPNGPIDIRHFLKL-CDLRRKFP---VLYKLEFQT--AAKVESNTCRHALKKNNLEKNQNPKCIP 136

Human   288 YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 352
            ||::||.|..|.|:.||||:|||:::...:.|.:|..|||.||||..:|||:|::|.:.|||:|.
  Fly   137 YDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTK 201

Human   353 LKERKECKCAQYWP------DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLI 411
            ..:..:..|.||||      :|    ||:|.:::.....|.::.:|.|.:.::.:......:|||
  Fly   202 TFDFAKVMCHQYWPPNMEVHEQ----YGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLI 262

Human   412 TQFHFTSWPDFGVPFTPIGMLKFLKKVKAC-------NPQYAGAIVVHCSAGVGRTGTFVVIDAM 469
            .|||:|.|.....||:. .:|:|.::|:..       .....|.|:||||.|.||:|.::.|||.
  Fly   263 LQFHYTEWYSHSCPFSN-ALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDAN 326

Human   470 LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYN 534
            |::...|...:|:|::.::|..|..:|:...||.|||..|.||.:.|.|...|:.|...|:....
  Fly   327 LELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKAR 391

Human   535 KIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPA-----NMKKNRVLQIIPYEFNRVIIPVKRGE 594
            :..||..|..:.|:.::..   |..:...|:...     |.:|||.:..:|.:..|..:...:|.
  Fly   392 RNSGTKMNEYQAEYDQICK---QTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN 453

Human   595 ENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP 659
            ..|||:|:.|:|||.:...||.::.|:.||:.:||.::::.:..::|:|.:...:.|: ...:||
  Fly   454 AFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQ-YPSFWP 517

Human   660 SDG-LVSYGDI----------TVELKKEEECESYTVRDLLVTNTR-----ENKSRQIRQFHFHGW 708
            :.. :..||.:          ...:|:.|    :.:...:|:.|.     :..:|.::.|....|
  Fly   518 NKSKMEKYGPVFSVHYVMSKSYTNIKQWE----FKINKKIVSLTEMMAGVKAPTRTVQLFQLTCW 578

Human   709 PEVG--IPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDV 771
            | :|  :||....::.::..|:..:.:....|:.|....|..|.|.:||.:..:|:|...|.:||
  Fly   579 P-MGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDV 642

Human   772 FQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 803
            ||.||::|..||.:|:.:.:|::||.:|..|:
  Fly   643 FQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	106/313 (34%)
PTPRA	NP_001372231.1	R-PTPc-A-2	574..801	CDD:350471	62/244 (25%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	88/247 (36%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	64/248 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2757
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48012
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.970