Protein Alignment PTPRA and Pez

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 139/604 - (23%)
• Similarity: 219/604 - (36%)
• Gaps: 181/604 - (29%)

Human    26 ICVSANNATTVAPSVGITRLINSSTAEPVKEE--------------AKTSNPTSSLTSLSVAPTF 76
            :..|::.:.|.||   :.|.:.:.:.||:.|.              |.|.......:|:..||..
  Fly   706 VVASSHKSATPAP---LQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGV 767

Human    77 SP-----NITLGPTYLTTVNSSDSDN-----GTTRTASTN--------------------SIGIT 111
            .|     |.:.......||||...|.     |..|.|||.                    .:|.|
  Fly   768 VPVPAARNASSNNVVTVTVNSPPDDGNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGAT 832

Human   112 --------------------ISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETF-----PPSGN 151
                                |:|.|..| ..||:....     :::|:|:|...|     ..|.:
  Fly   833 PPPRQHRSTASLNKSSTVDMITPAGDTL-QQQFSAMNL-----SANTSASTSSMFNSTLDTTSSS 891

Human   152 SDSKD----------RRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHS-------- 198
            :.|||          .|.:||.......|..                :|...||.||
  Fly   892 AASKDLKRKKRWNFLSRSKTPDKQKSATLGR----------------EKATTAGQHSKLAAKLKL 940

Human   199 --NSFRLSNGRTEDV-EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP 260
              :...|.|..:..| :||  |:..|...          |||.:.:::::: |::||. ||..:|
  Fly   941 AQDDLNLPNRWSTGVNKPQ--PISGRYSK----------DKLCQILDQKLS-DSQLFM-EFERIP 991

Human   261 ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDS--DYINASFING-YQEKNKF- 321
            .....|..|.|..|||:.||...|.||||.:||.|||..   |:  .|:|||.|:. ...|.:|
  Fly   992 KRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCR---DNRHGYVNASSISATVGTKQRFY 1053

Human   322 IAAQGPKEE-TVNDFWRMIWEQNTATIVMVT--------NLKERKECKCAQYWPDQGCWTYGNIR 377
            |.||.|:|. |:..||:.:||.:...:|.:|        |..:|.|              :|..:
  Fly  1054 IVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLE--------------FGQFQ 1104

Human   378 VSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA-- 440
            |..|........|..|..:..|..    :..|.:....:..|.:...|......|.||:::.:
  Fly  1105 VYQEFSQTTDRCTTIKLRLYHVPS----RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVR 1165

Human   441 ------------CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRC 493
                        .||    .:::||..|.||:|..:..|.:|..:.....:|:...:.::|.||.
  Fly  1166 LASTQEVPPGHNTNP----PVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRD 1226

Human   494 QMVQTDMQYVFIYQALLEH 512
            .::.:..||.|||..|:.:
  Fly  1227 SIIPSLAQYKFIYNLLITY 1245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	82/315 (26%)
		R-PTPc-A-2	574..801	CDD:350471
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		PTP_DSP_cys	1036..1246	CDD:475123	54/232 (23%)