Protein Alignment PTPRA and Ptp10D

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 198/745 - (26%)
• Similarity: 309/745 - (41%)
• Gaps: 185/745 - (24%)

Human    41 GITRLINSSTAEPVKEEAKTSNPTSSLTSLSVA--PTFSPNITLGPTYLTTVNSSDSDNGTTRTA 103
            |..|:.....||   ::||.::.....:.|.|.  ..:.|...:.|.|.....|.:.....|...
  Fly  1088 GQVRMYTIIVAE---DDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENC 1149

Human   104 STNSIGITISP--NGT--------WLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRR 158
            ..:.||....|  :||        :...::|||               |..:||...:.|
  Fly  1150 DNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTD---------------TAYSFPIQTDQD----- 1194

Human   159 DETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSP 223
            :.:.|:|:.|.|:  :::|.::.:|:      ||:        |.:|.|....:.::...::...
  Fly  1195 NTSLIVAITVPLT--IILVLLVTLLF------YKR--------RRNNCRKTTKDSRANDNMSLPD 1243

Human   224 STNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPY 288
            |...:..|:.:....|......||.:..|.|||..|........|..|....|:.|||:.|||||
  Fly  1244 SVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPY 1308

Human   289 DHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNL 353
            ||||..|.||:....||||||:::.|:....:||..|||...|.:|||||.||.|:..|||:|..
  Fly  1309 DHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRC 1373

Human   354 KERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFT 417
            .|:...||.|||| |.....||:|:|.:.:.:...|:.:.:|.:.:..:      ||::..||||
  Fly  1374 FEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSE------QRILRHFHFT 1432

Human   418 SWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----IVVHCSAGVGRTGTFVVIDAMLDMMHTERK 478
            :|||||||..|..:::|::..:    ...||    |||||||||||:|||:.:|.:|..::|...
  Fly  1433 TWPDFGVPNPPQTLVRFVRAFR----DRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDY 1493

Human   479 VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNG 543
            ||::|.|..:|.:|..||||:.||:.|:|.||. .|.|...:...:.|.|           .|.|
  Fly  1494 VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENIVGPAREMH-----------DNEG 1546

Human   544 LEEEFKKLTSIKIQNDKMRTGNLPANMK---KNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFI 605
            .|.:       ::|.|:  .|::.|.::   .:..||             :...|..|..||:.:
  Fly  1547 YEGQ-------QVQLDE--NGDVVATIEGHLSHHDLQ-------------QAEAEAIDDENAAIL 1589

Human   606 DGYRQKDSYIASQGPLL------HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV 664
            ..         .|.||.      ||                               ...|:..:.
  Fly  1590 HD---------DQQPLTSSFTGHHT-------------------------------HMPPTTSMS 1614

Human   665 SYG------------DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDG 717
            |:|            |....:..:.:..:..|..|:     :||            |...|..|.
  Fly  1615 SFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLV-----DNK------------PSSMICKDS 1662

Human   718 K-GMISIIAAVQKQQQQ------SGNHPIT 740
            | |.|.::.:.|:||||      .|.|.||
  Fly  1663 KGGNIDVLESQQQQQQQQQQQPNQGGHNIT 1692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	118/299 (39%)
		R-PTPc-A-2	574..801	CDD:350471	34/192 (18%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:394996
		fn3	220..304	CDD:394996
		FN3	278..>734	CDD:442628
		FN3	583..671	CDD:238020
		fn3	787..850	CDD:394996
		fn3	866..935	CDD:394996
		fn3	959..1043	CDD:394996
		PTP_tm	1083..1187	CDD:465889	22/116 (19%)
		R3-PTPc	1301..1522	CDD:350396	99/230 (43%)