Protein Alignment PTPRA and Ptp4E

DIOPT Version :10

• Sequence 1: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Sequence 2: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 163/494 - (32%)
• Similarity: 243/494 - (49%)
• Gaps: 85/494 - (17%)

Human    89 TVNSSDSD-------NGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETF 146
            |:.:::.|       ||..|..:|..|.|.     .:..:::|||           |..::|.|
  Fly  1200 TIGTANCDKHQAGYCNGPLRAGTTYRIKIR-----AFTDEDKFTD-----------TVYSSPIT- 1247

Human   147 PPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLY-MLRFKKYKQAGSHSNSFRLSNGRTED 210
                     ..|.:|.|:|..|  |::|::..:::|:| ..|.:..::|.      :|:..:.|
  Fly  1248 ---------TERSDTVIVAATV--SAVLLVAMVLVVVYCQHRCQLIRRAS------KLARMQDE- 1294

Human   211 VEPQSVPLLARSP----STNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 271
                    ||..|    :.||   |:.|....|......||.:..|.|||..|........|..|
  Fly  1295 --------LAALPEGYITPNR---PVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFA 1348

Human   272 SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW 336
            :...|:.|||:.|||||||||..|.||:....||||||:::.|:....:||..|||...|..:||
  Fly  1349 NLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFW 1413

Human   337 RMIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVG 400
            ||.||.|:..|||:|...|:...||.|||| |:....||:|:|.:...|...|:::.:|
  Fly  1414 RMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEF------ 1472

Human   401 DMTNRK-PQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 464
             |.:|. ..|::..||||:|||||||..|..:::|::..:.........|:|||||||||:|||:
  Fly  1473 -MVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFI 1536

Human   465 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 529
            .:|.:|..:|....||::|.|..:|.:|..||||:.|||.|:|.||. .|.|...|...|||.|
  Fly  1537 ALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA-VLEGKEHLLADSLELH- 1599

Human   530 QKIYNKIPGTSNNGLEEEFKKLTSIKIQND-KMRTGNLP 567
                      :|:|.|     :|.|.::.. :.:.|.||
  Fly  1600 ----------ANDGYE-----VTKIYLERQPQTKMGTLP 1623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	120/296 (41%)
		R-PTPc-A-2	574..801	CDD:350471
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996
		fn3	1013..1092	CDD:394996
		PTP_tm	1127..1247	CDD:465889	13/62 (21%)
		R3-PTPc	1358..1579	CDD:350396	98/227 (43%)