Protein Alignment PTPN13 and Ptp99A

DIOPT Version :10

• Sequence 1: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Sequence 2: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 1006
• Identity: 226/1006 - (22%)
• Similarity: 345/1006 - (34%)
• Gaps: 396/1006 - (39%)

Human  1807 TVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDT----------DVTNMTHTDAVNLLRA 1861
            :.|.||.|                |.:.||..|:.:..|          ||||:   |.|.:...
  Fly     6 SATYGNHR----------------GLIIPGFVLLLILATLPATQAGRIFDVTNL---DYVKVNAE 51

Human  1862 ASKTVRLVIGRVLE-------------------LPRIPMLPHLLPDITLTCNKEELGFSLCGGHD 1907
            |.|.|.:....|.|                   ..|||:|..  |.|.|..:...|.||.....|
  Fly    52 AGKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFANRIPLLHS--PRIQLLSDNFGLQFSPSLASD 114

Human  1908 SLYQVVYISDINPRSVAAIEGNLQLLD--------------------------------VIHYV- 1939
            :   ..||..:|.|.:.....:|.:.|                                |.|::
  Fly   115 T---SEYICLVNDRHIPEAIVDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFII 176

Human  1940 ------NGVSTQ--------GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAV-----SA 1985
                  :|:..|        ..|..:|......::.|..|.|. |.|.:.|.||.|..     .|
  Fly   177 ETREGEDGIWEQLARIYTKTNATSYQVTGLTPFTVYSFRLLAV-NKLGISPPSKESYYIVTLREA 240

Human  1986 P-----KSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKG 2045
            |     .:|..|.|.:....|..|..|:    |:.||.:       |...||:         |:.
  Fly   241 PTGKPIPTTAHNTSSTSVYISWKAPPPD----TILGEFL-------GYRITYR---------PRD 285

Human  2046 SFPNQSSNYSKCPNNSESYIQEDDIYDDSQEAEVIQ---------------------SLLDVVDE 2089
            ..||         :..|.||:::.:  :|.|.:.:|                     ::|.:.||
  Fly   286 RDPN---------DTKEIYIRDNTV--ESHEIQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDE 339

Human  2090 ----EAQNLL-----------------NENNA-AGY----------------------------- 2103
                :.|||.                 |:|.| |||
  Fly   340 GVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFE 404

Human  2104 --SCGP----------GTLKMNGKLSEERTEDTDCDGSPLP------------------------ 2132
              :..|          .|.|..|:.|::..:.||..|...|
  Fly   405 LQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFY 469

Human  2133 ---EYFTEATKMNG--------------------------CEEYCEEKVK--------------- 2153
               :::...|::.|                          ...|.|.||.
  Fly   470 NTIDFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLG 534

Human  2154 --SES-LIQ-KPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVV-------- 2206
              ||| :|| :|..:|..           |:.|.:|.|.:          ||||..:
  Fly   535 KFSESRIIQLQPNCEKLQ-----------PLLRQSHNDYN----------LAVLVGIIFSCFGII 578

Human  2207 -----------KVLPSGKY---------------------TGANLKSVIRV---------LRGLL 2230
                       |...:..|                     .|..:::.:.|         |....
  Fly   579 LIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADG 643

Human  2231 DQGIPSKELENLQELKPLDQ--CLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINA 2287
            |.|. |:|.|.:|.....|.  |...|..||:|||||.||..||.:||.|....|      ||||
  Fly   644 DIGF-SREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINA 707

Human  2288 SFIKIPVGKEE-FVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGK 2351
            :||.   |.:: ..:|..|||||.|...||:|||||:..:|.|:|..||..:.||..|||....:
  Fly   708 NFID---GYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE 769

Human  2352 TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRH------ISHLNFTAWPDHDTPSQPDDL 2410
            |..|   :::.|:..:.:..:.||.:.::.::.::.:.      :...::|.||||.||..|..:
  Fly   770 TYGV---IQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPV 831

Human  2411 LTFI--SYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMV 2473
            |.|:  |...:...:|||:.|||||:||:||.|.:|.:|..|.|....::...:|.:|.||:.:|
  Fly   832 LNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLV 896

Human  2474 QTEDQYIFCYQVILYVL----TRLQAEEEQK 2500
            |||:||||.:..::..:    |.|.||:.::
  Fly   897 QTEEQYIFLHDALVEAIASGETNLMAEQVEE 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	571..666	CDD:340715
		B41	573..781	CDD:214604
		PH-like	777..877	CDD:473070
		PDZ1_PTPN13-like	1090..1181	CDD:467285
		PTN13_u3	1177..1367	CDD:465189
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181
		PDZ4_PTPN13-like	1789..1873	CDD:467182	18/75 (24%)
		PDZ5_PTPN13-like	1884..1970	CDD:467183	22/132 (17%)
		PTPc-N13	2257..2490	CDD:350445	91/247 (37%)
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	15/96 (16%)
		FN3	243..337	CDD:238020	22/124 (18%)
		fn3	343..430	CDD:394996	13/86 (15%)
		FN3	442..520	CDD:238020	7/77 (9%)
		R5-PTPc-1	704..907	CDD:350397	76/208 (37%)
		R5-PTP-2	989..1182	CDD:350398