Protein Alignment PTPN13 and pyp2

DIOPT Version :10

• Sequence 1: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Sequence 2: NP_594899.1
• Gene: pyp2 / 2542200
• PomBaseID: SPAC19D5.01
• Length: 711
• Species: Schizosaccharomyces pombe
• Alignment Length: 882
• Identity: 199/882 - (22%)
• Similarity: 306/882 - (34%)
• Gaps: 307/882 - (34%)

Human  1741 QSYQPQSESAS----SSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEK 1801
            :|::.|:||.|    .....||.:.||            ||         .:.|.|...|::...
pombe    15 KSFEEQTESVSWIIDLRLHSKYAVSHI------------KN---------AINVSLPTALLRRPS 58

Human  1802 GSLG--FTVTKGNQRIGC-----------------YVHDVIQDPAKSDGRLKPGDRLIKV----N 1843
            ..:|  |...|.|.::..                 .::|::|       :.:.|....|:    |
pombe    59 FDIGKVFACIKCNVKVSLDEINAIFLYDSSMAGMNRIYDLVQ-------KFRRGGYSKKIYLLSN 116

Human  1844 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS 1908
            ..:....:|.||:                                ::....||
pombe   117 GFEAFASSHPDAI--------------------------------VSTEMVKE------------ 137

Human  1909 LYQVVYISDINPRSVAAIEGNLQLLDVIHY--VNGVSTQGMTLEEVNRALDMSLPSLVLKATRND 1971
              .|.|..|||...         .||::|.  .:.|||.        .:.|.|.|   |:...|.
pombe   138 --SVPYKIDINENC---------KLDILHLSDPSAVSTP--------ISPDYSFP---LRVPINI 180

Human  1972 LPVVPSSKRSAVS------------------APKSTKGNGSYSVGSC----SQPALTPNDSFSTV 2014
            .|  |....|.||                  .|.|.....:.||.||    ..|...||.:|..
pombe   181 PP--PLCTPSVVSDTFSEFASHAEYPGFSGLTPFSIHSPTASSVRSCQSIYGSPLSPPNSAFQA- 242

Human  2015 AGEEINEISY----PKGKCST-------------------YQIKGSPNL-TLPKGSFPNQSSNYS 2055
                  |:.|    |...|::                   .|....|:| ::|  |:|  |||..
pombe   243 ------EMPYFPISPAISCASSCPSTPDEQKNFFIVGNAPQQTPARPSLRSVP--SYP--SSNNQ 297

Human  2056 KCPNNS-----ESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK 2115
            :.|:.|     .:|::..::.:.|    :.|:.|:::..  :::..::||........|.|:...
pombe   298 RRPSASRVRSFSNYVKSSNVVNPS----LSQASLEIIPR--KSMKRDSNAQNDGTSTMTSKLKPS 356

Human  2116 LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDEL-P 2179
            :....|.|     :|.|.....|.|.      |..|....|:..|  |.|.......||..:: |
pombe   357 VGLSNTRD-----APKPGGLRRANKP------CFNKETKGSIFSK--ENKGPFTCNPWGAKKVSP 408

Human  2180 IERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQE 2244
                                    |..:||     ...|..|:.          ...|.||.::.
pombe   409 ------------------------PPCEVL-----ADLNTASIF----------YKFKRLEEMEM 434

Human  2245 LKPL-------DQCLIGQTKEN--RRKNRYKNILPYDATRVPLGDEGG---YINASFIKIPVGKE 2297
            .:.|       |.|.:..::..  .|||||.:|:|||.|||.|....|   |||||  .|.||.:
pombe   435 TRSLAFNDSKSDWCCLASSRSTSISRKNRYTDIVPYDKTRVRLAVPKGCSDYINAS--HIDVGNK 497

Human  2298 EFVYIACQGPLPTTVGDFWQMIWEQKST--VIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLR 2360
            :  |||||.|.|.|:.|||:|:|....|  ||.|:|...|....||.:|||:.......:...||
pombe   498 K--YIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSEKCSQYWPDNKDHALCLEGGLR 560

Human  2361 LALVRMQQLKGFVVRAMTLEDIQTR-----------EVRHISHLNFTAWPDHDTPSQPDDLLTFI 2414
            :::.:.:          |.||::..           ..::|.|.....|.|...|    |:.:..
pombe   561 ISVQKYE----------TFEDLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHP----DIESIT 611

Human  2415 SYMRHIHR---SGPIITHCSAGIGRSGTLICIDVVLGL----------ISQDLDFDISDLVRCMR 2466
            ..:|.|.:   .||:..|||||:||:||.|.:|.:|.:          :....|| |.:.|..:|
pombe   612 GIIRCIDKVPNDGPMFVHCSAGVGRTGTFIAVDQILQVPKNILPKTTNLEDSKDF-IFNCVNSLR 675

Human  2467 LQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQP 2503
            .||..|||..:|:.|.|.|:.|    |.:...|..:|
pombe   676 SQRMKMVQNFEQFKFLYDVVDY----LNSGVNQASKP 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	571..666	CDD:340715
		B41	573..781	CDD:214604
		PH-like	777..877	CDD:473070
		PDZ1_PTPN13-like	1090..1181	CDD:467285
		PTN13_u3	1177..1367	CDD:465189
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181
		PDZ4_PTPN13-like	1789..1873	CDD:467182	15/106 (14%)
		PDZ5_PTPN13-like	1884..1970	CDD:467183	17/87 (20%)
		PTPc-N13	2257..2490	CDD:350445	88/263 (33%)
pyp2	NP_594899.1	DSP_MapKP	4..129	CDD:238723	25/141 (18%)
		PHA03247	<159..304	CDD:223021	37/168 (22%)
		PTP_fungal	486..693	CDD:350509	71/225 (32%)