Protein Alignment PTPN13 and frm-5.2

DIOPT Version :10

• Sequence 1: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Sequence 2: NP_001360605.1
• Gene: frm-5.2 / 176821
• WormBaseID: WBGene00021406
• Length: 1386
• Species: Caenorhabditis elegans
• Alignment Length: 1533
• Identity: 335/1533 - (21%)
• Similarity: 570/1533 - (37%)
• Gaps: 479/1533 - (31%)

Human   178 GNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMG 242
            |.|||.|...      .|...:..::||.|.|.            :|..|:|:      ||.|
 Worm   187 GTLSGRDPFD------EDSGNSNENQLREKKLH------------KKEQLAHR------LSSS-- 225

Human   243 FLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLC 307
                         .:.:.:.|..||.....:  |.....|:.|.||..|               .
 Worm   226 -------------SEEIVEASIHEDEPIVMA--QIPEEKPKPKAIPAFD---------------N 260

Human   308 TADRDFSSGETATYRRCHPEAVTVRTSTTP--------RKKEARYSDGSIALDIFGPQKMDPIYH 364
            ..|.||.:.....    |..||.:.|..:|        |...||:...:::|           ..
 Worm   261 AYDADFDNSPPLH----HYSAVHLETGLSPLEEAQRALRANRARHKPSNVSL-----------AE 310

Human   365 TRELPTSSAISSALDRIRERQKK---------LQVLREAMNVEEPVR-----RYKTYHGDVFSTS 415
            ..:|......|:|.|..||.:::         :.|||:.:.|||..:     ||:.      |..
 Worm   311 EAKLAARQRYSNASDIRREEEEEVVEEDPAVVVPVLRKDLEVEEAPKSVRPPRYRK------SRE 369

Human   416 SESPSI----ISSESD--------FRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETP 468
            .|.|.:    :..|.|        |.:.|::..|...:|.:.:...||      .:.|.:|...|
 Worm   370 IEEPVVVDRFVEEEVDEKEDIDAIFEKYRKTSVSADPKSHTPILMADE------YKEPQKQVPAP 428

Human   469 FEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMT-Q 532
            .   ::.||..:.::...|  :.::::.|||                 ||   |.:....:|. :
 Worm   429 V---VVAQESPILKRRNSL--VPSRISGRQS-----------------TR---RSVTSVRSMRGK 468

Human   533 RKLRNFFGPEFVKMTIEPFISLDLPRSILTKK-----GKNEDNRRKVNIMLLNGQRLELTCDTKT 592
            ||.|..  |||..:|....|.|..|   .|||     .:.||....|.  |||||::|:.|.:..
 Worm   469 RKTRAI--PEFFDLTRHQNIRLRAP---ATKKKRISLHRVEDTEAVVE--LLNGQKVEVACRSDV 526

Human   593 ICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
            |.:|||.::|.::.:.||..|.|:.|:|.|::|::...:|.|.||.|||...:...|  |.:.|.
 Worm   527 ISRDVFSLIVQNMNINEHVFFGLSFLRDGEHYFIEDHQRLEKFAPSGWKSVARVGVK--VPYVLH 589

Human   658 FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVS 722
            .|.||:...:..|:..:|.::.|||.|:|:||||:....:.:..||:||||||:|:..|.|. ..
 Worm   590 LRFKFYPQILDFIKTDVTMNELYLQCRRDVLEERIQPKRDAAFELAALALQAEFGNRPPPVI-TD 653

Human   723 YFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEK 787
            ||.::||||.:.....|.|.:|..|.:||..|.|....|.:.:::::|||..::|.|.|||...|
 Worm   654 YFDIQHYLPKKYSSFEDQSRLKNILAELHGHYAGTRISEAKHKYIQICQRHPDFGAHVHRVFRTK 718

Human   788 KS----------QTG--ILLGVCSKGVLVFEVHN--------------GVRTLVLRFPWRETKKI 826
            .:          .||  :.:|:..:|:.::|..|              |.|.::....|.:|:.:
 Worm   719 PTSAHGASPFDPDTGSSLWIGIMPRGISIYEQQNHHIPNKYMSIARQGGAREVIAEHVWPQTQTL 783

Human   827 SFSKKK---ITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASF 888
            .|.||:   :.:....:.|:..|.||:.....|.:...:.||::.::||..:|
 Worm   784 QFDKKRFVIVAVGAHDEQIESTFYTDHHSKSSYFVRFAASQHRWMMKMRQWKS------------ 836

Human   889 RSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVR----------PLSVQA-EILKRLSCSELSL 942
                    ::|..|..:|:....:...|:....:|          ||...| :|..::|.|:
 Worm   837 --------TLRHENTIQAMPDVIVEGQTIPPAPIRQGLEESPPSTPLLASADQIFAKMSVSQ--- 890

Human   943 YQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQM 1007
            .:|..|             :|.|:                        |||        .||
 Worm   891 EKPAAN-------------RPAEL------------------------PPP--------APS--- 907

Human  1008 SRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIE-----DPGQAYVLGMTMHSSGNSSS 1067
                            ||..|..:...|....:|.:.:.|     |.|.....||
 Worm   908 ----------------SKFAAQYDTVDEGIVCDSQAENFERVDSTDNGNVTPRGM---------- 946

Human  1068 QVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPA 1132
                 :.|:|                  |.||...|||..::.|...|  ..|:::..||..|..
 Worm   947 -----QFDIL------------------LVKDPANGLGLTLVDGNLNG--VPGVYVKLVADNGAG 986

Human  1133 DLDG-CLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1196
            ...| |:  |||::.|.:.|:||.....|:|:::...:.|.:||::              |...:
 Worm   987 MKAGVCV--GDRIVQVGTESMEGHDRLHAVELVRRCGQRVPMVIAR--------------LDGLI 1035

Human  1197 KNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGG--LREGSLSSQDSRT-----ESA 1254
            ::....|:.|..||            |     .:.||..|.|  |...:.::..|||     ::|
 Worm  1036 RHQKDVSAEMLASA------------G-----RKKSFTSSSGDLLNAPNRTNGQSRTPPAPRKAA 1083

Human  1255 SLSQSQVNGFFA---------------------SHLGDQTWQESQHGSPSPSVISKATEKETFTD 1298
            :..|..|:.|.|                     .||.:...::.::..|:.|:.  |.:::....
 Worm  1084 NRRQRAVSDFGAIGDALPTLDGDNLINIKAISGLHLDESDEEKGEYRLPTTSMY--AFDRDDDLQ 1146

Human  1299 SNQSKTKKPGISDVTD------YSDRGDSDM-----DEATYSSSQDHQTPKQESSSSVNTSNKMN 1352
            ::..::|||.....:.      |:.|.:.::     :||..||..|.|..:.:.
 Worm  1147 ASIKESKKPAPEPKSGELRKYRYARRSNLEIAEEIEEEAVESSDDDGQIDEGKR----------- 1200

Human  1353 FKTFSSSPPKPGDIFEVELAKNDN-SLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGR 1416
                         :.:|||.:|:| |||:.:..|           .|.:.:|.:..:.|. |...
 Worm  1201 -------------VIDVELDRNENGSLGVQIASL-----------SGRVCIKQLTSEPAI-SHPD 1240

Human  1417 IHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQG 1481
            |..||.:|.|||:::||..|::.|..||..|..|.|.:::             |....|||:...
 Worm  1241 IRVGDVLLYVNGIAVEGKVHQEVVAMLRGGGDRVVLGVQR-------------PPPAYSDQHHAS 1292

Human  1482 QGPEKVKKTTQVKDYSFVTEENTFEVKLFKN-SSGLGFSFSR---EDNLIPEQINASIVRVKKLF 1542
                           |.........|.|.|. .:.||.|.::   .|.:.          ::.:.
 Worm  1293 ---------------STSASAPLISVMLLKKPMATLGLSLAKRTMSDGIF----------IRNIA 1332

Human  1543 PGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580
            ....|:..|.:.|||.::.::|..:.|.:...::..|:
 Worm  1333 QDSAASSEGTLRVGDRLVSLDGEPVDGFTPATILEKLK 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801	5/11 (45%)
		FERM_F1_PTPN13	571..666	CDD:340715	34/94 (36%)
		B41	573..781	CDD:214604	76/207 (37%)
		PH-like	777..877	CDD:473070	28/128 (22%)
		PDZ1_PTPN13-like	1090..1181	CDD:467285	26/91 (29%)
		PTN13_u3	1177..1367	CDD:465189	35/228 (15%)
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254	29/91 (32%)
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181	15/81 (19%)
		PDZ4_PTPN13-like	1789..1873	CDD:467182
		PDZ5_PTPN13-like	1884..1970	CDD:467183
		PTPc-N13	2257..2490	CDD:350445
frm-5.2	NP_001360605.1	B41	510..712	CDD:214604	76/206 (37%)
		PH-like	708..837	CDD:473070	29/148 (20%)
		PDZ_canonical	949..1029	CDD:467153	27/101 (27%)
		PDZ	1200..1282	CDD:214570	29/130 (22%)
		PDZ_canonical	1305..1381	CDD:467153	14/76 (18%)