DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTPN12 and CG42327

DIOPT Version :9

Sequence 1:	NP_002826.3	Gene:	PTPN12 / 5782	HGNCID:	9645	Length:	780	Species:	Homo sapiens
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	86/296 - (29%)
Similarity:	137/296 - (46%)	Gaps:	66/296 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    61 KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVY-GPKAYVATQGPLANTVIDFWRMIWEY 124
            ||||.:::|...:||.|..:.....::|||||:::|.. .|..|:|.|.||.:|..||||||||.
  Fly  1135 KNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQ 1199

Human   125 NVVIIVMACREFEMGRKKCERYWPLYG--EDPITFAPFKISCEDEQARTDYFIRTLLLEFQN--E 185
            ...:|:.|....|.|.::|..|.|...  ::..::..::::.:..:.:..|.|.||:|:..:  |
  Fly  1200 QSRVIIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEE 1264

Human   186 SRRLYQFHYVNWPDHDVPSSFDSILDMI----SLMRKY--------------------------- 219
            ||.|..:.| .||:..||:....|:.|:    |.::.|
  Fly  1265 SRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAE 1328

Human   220 ----QEHE--------------DVPICIHCSAGCGRTGAICAIDYTWNLLKAGK----IPEEFNV 262
                ..||              ..|:.:|||.|.||||.|.|.|.....|:..|    ||:
  Fly  1329 AGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQ---- 1389

Human   263 FNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL 298
              |:..:|..|.||||||||||.::: :|.::..::
  Fly  1390 --LVYYVRRGRASAVQTKEQYEFIYK-VASMYAAKI 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPN12	NP_002826.3	PTPc	28..292	CDD:214550	85/288 (30%)
		PTPc	60..292	CDD:238006	85/288 (30%)
		Substrate binding. /evidence=ECO:0000305\|PubMed:27134172	63..67		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250	231..237		3/5 (60%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	345..438
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..725
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..780
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	85/287 (30%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	85/287 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900