DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPN12 and Ptpn12

DIOPT Version :9

Sequence 1:	NP_002826.3	Gene:	PTPN12 / 5782	HGNCID:	9645	Length:	780	Species:	Homo sapiens
Sequence 2:	NP_476456.2	Gene:	Ptpn12 / 117255	RGDID:	620894	Length:	766	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	654/781 - (83%)
Similarity:	693/781 - (88%)	Gaps:	16/781 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYK 65
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYK 65

Human    66 DILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIV 130
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat    66 DILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVIIV 130

Human   131 MACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYV 195
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat   131 MACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYV 195

Human   196 NWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 NWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEF 260

Human   261 NVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSI 325
            |||||||||||||||||||||||||||||||||||||||||||||||||.|| |||:|.||||||
  Rat   261 NVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDG-NEISTGNMVSSI 324

Human   326 EPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPK 390
            :.||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
  Rat   325 DSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPK 389

Human   391 PVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTL 455
            |||||.|.||...||||||.||.:|.|::||.:|..|||||:|||||||||||||||||||||||
  Rat   390 PVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTL 454

Human   456 LNRGHAIKIKSASPCIADKISKPQELSS-DLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDT 519
            |||||||||||||..:.||.|||||||| ||.|.|.|||||.|||.:..:....: .||||||.|
  Rat   455 LNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPES-SEESQNSHT 518

Human   520 PPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDH 584
            |||||.||||:|||||||.||||||.|:.|     |.|.:.||.||||.||:.|.:.|:.||.:|
  Rat   519 PPRPDCLPLDKKGHVTWSLHGPENATPVSD-----SPDNHSQTLKTVSSTPNSTAEEESHDLTEH 578

Human   585 DNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMS 649
            .|:|||.|.|||||||||||||||||.|||||||:|||:|||||||||.|:||||..||:|||||
  Rat   579 HNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVLPMS 643

Human   650 IARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSE 714
            |||..:||..|||||||.||||:||||||||||||||||   :.|:||:|.||.|||.||.::||
  Rat   644 IARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLA---DMPIRSDWHELPSQECSEHRESE 705

Human   715 GLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEW 779
            |||||.|:|  |.||..|   ...|.||||||:|:|:|:.||.||||||||||||||||||||||
  Rat   706 GLITSGNDK--HDAGVSH---TAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPRDPPSEW 765

Human   780 T 780
            |
  Rat   766 T 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPN12	NP_002826.3	PTPc	28..292	CDD:214550	261/263 (99%)
		PTPc	60..292	CDD:238006	229/231 (99%)
		Substrate binding. /evidence=ECO:0000305\|PubMed:27134172	63..67		3/3 (100%)
		Substrate binding. /evidence=ECO:0000250	231..237		5/5 (100%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	345..438		75/92 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..639		90/136 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..725		48/67 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..780		29/35 (83%)
Ptpn12	NP_476456.2	PTPc	28..292	CDD:214550	261/263 (99%)
Ptpn12	NP_476456.2	PTPc	60..292	CDD:238006	229/231 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691953
Domainoid	1	1.000	713	1.000	Domainoid score	I3446
eggNOG	1	0.900	-	-		E2759_KOG0789
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37691
Inparanoid	1	1.050	1309	1.000	Inparanoid score	I3520
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38897
OrthoDB	1	1.010	-	-		D102241at33208
OrthoFinder	1	1.000	-	-		FOG0010932
OrthoInspector	1	1.000	-	-		oto139250
orthoMCL	1	0.900	-	-		OOG6_110426
Panther	1	1.100	-	-	LDO	PTHR45983
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3417
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270