Protein Alignment G6PC2 and G6P

DIOPT Version :10

• Sequence 1: NP_066999.1
• Gene: G6PC2 / 57818
• HGNCID: 28906
• Length: 355
• Species: Homo sapiens
• Sequence 2: NP_001097063.1
• Gene: G6P / 33476
• FlyBaseID: FBgn0031463
• Length: 350
• Species: Drosophila melanogaster
• Alignment Length: 362
• Identity: 100/362 - (27%)
• Similarity: 159/362 - (43%)
• Gaps: 53/362 - (14%)

Human    12 IQHLQKDYRAYYT------FLN---------------FMSNVGDPRNIFFIYFPLCFQFNQTVGT 55
            |.|:..|  ||:|      |:|               |:|...:|..:|.|..|||..|:|.:..
  Fly     4 IVHILSD--AYHTTLTRELFINEWAQERLSFGRPLWHFLSVHLEPNKMFNIIIPLCGIFSQEILV 66

Human    56 KMIWVAVIGDWLNLIFKWILFGHRPYWWVQE---TQIYPNHSSPCLEQFPTTCETGPGSPSGHAM 117
            .:.....:...||...|||....||.|:::|   ..:.....:..||....:||...|.|..|:|
  Fly    67 HLFTAFTLISTLNSFEKWIYPETRPLWFLREQFANNVVVKKPAVALESHQLSCEMTGGLPCAHSM 131

Human   118 GASCVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQIS--VC--ISRVFIATHFPHQ 178
              :...:|::.|:.....| .|:|:    .|..||...:.:|:.|.  ||  :||:::||.|.||
  Fly   132 --TFTVFVLILASFFFVHC-WDRFA----ALRSSFCRCIMYLLIIGMVVCMWLSRLYLATEFLHQ 189

Human   179 VILGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFL--FAVGFYLLLRVLNIDLLWSVPIAKK 241
            .|||...|:.....||.......:....|..:.:| ||  .|:..|.:...||||..|||..|.|
  Fly   190 CILGSYLGIRSLCTFEGNVKYLFSRPRRYAVSAVF-FLGGLALSVYYVKLELNIDPHWSVREAFK 253

Human   242 WCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTSLTILQL 306
            ||..|.::..:..|...|||:||.|.||  |:.|.::.|..:..     ||...|..  |.:|:.
  Fly   254 WCPEPTYLRHEVGPIFALVRDLGNLMGL--ALASPLYKLEMKQS-----SFWRRCRF--LGVLEF 309

Human   307 YHF-LQIPTHEE---HLFYVLSFCKSASIPLTVVAFI 339
            .:: |:..|.::   .:|....|.::....|.::.::
  Fly   310 VNYGLRFSTFKQSGRFVFLTYEFLRNVIHSLVLIKYV 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G6PC2	NP_066999.1	PAP2_glucose_6_phosphatase	38..278	CDD:239476	78/248 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	352..355
G6P	NP_001097063.1	PAP2_glucose_6_phosphatase	49..290	CDD:239476	78/250 (31%)