Protein Alignment PTPN11 and ptpn11

DIOPT Version :10

• Sequence 1: NP_001317366.1
• Gene: PTPN11 / 5781
• HGNCID: 9644
• Length: 597
• Species: Homo sapiens
• Sequence 2: XP_012818337.1
• Gene: ptpn11 / 549586
• XenbaseID: XB-GENE-22063677
• Length: 596
• Species: Xenopus tropicalis
• Alignment Length: 601
• Identity: 563/601 - (93%)
• Similarity: 576/601 - (95%)
• Gaps: 9/601 - (1%)

Human     1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65

Human    66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKG 130

Human   131 KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVE 195
            |||||||||||||||||||||||||||.|||||||||||||||||:|||||||||:|||||||||
 Frog   131 KHGSFLVRESQSHPGDFVLSVRTGDDKAESNDGKSKVTHVMIRCQDLKYDVGGGEKFDSLTDLVE 195

Human   196 HYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECK 260
            |||||||||||||||||||||||||||||||||||:||||.|||.||.|||||||||||||||||
 Frog   196 HYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVKELSKPAETADKFKQGFWEEFETLQQQECK 260

Human   261 LLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKK 325
            ||||||||||||||||||||||||||||||.||||||||.||||||||||||||||||||.||||
 Frog   261 LLYSRKEGQRQENKNKNRYKNILPFDHTRVELHDGDPNEQVSDYINANIIMPEFETKCNNPKPKK 325

Human   326 SYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKE 390
            .||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
 Frog   326 RYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEFALKEYGVMRVRNVKE 390

Human   391 SAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMD 455
            :.||||.||||||||||    |||||||||||||:||||||||:||||||||||||||||:.|.|
 Frog   391 TPAHDYILRELKLSKVG----QGNTERTVWQYHFKTWPDHGVPTDPGGVLDFLEEVHHKQDGIAD 451

Human   456 AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYM 520
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
 Frog   452 AGPVVVHCSAGIGRTGTFIVIDILIDVIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYM 516

Human   521 AVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCT----PTPPCAEMREDSA 581
            |||||||||||||||||||||||||||||||||::| :||||||||||    |||...|||||:.
 Frog   517 AVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLSEQ-AGDQSPLPPCTPTPLPTPTLPEMREDAG 580

Human   582 RVYENVGLMQQQKSFR 597
            ||||||||||||||||
 Frog   581 RVYENVGLMQQQKSFR 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	97/97 (100%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	103/106 (97%)
		PTPc-N11	272..528	CDD:350453	237/255 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..575		16/26 (62%)
ptpn11	XP_012818337.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	97/97 (100%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	103/106 (97%)
		PTPc-N11	272..524	CDD:350453	237/255 (93%)