DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPN11 and Ptp61F

DIOPT Version :10

Sequence 1:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens
Sequence 2:NP_476687.1 Gene:Ptp61F / 38160 FlyBaseID:FBgn0267487 Length:548 Species:Drosophila melanogaster


Alignment Length:367 Identity:123/367 - (33%)
Similarity:186/367 - (50%) Gaps:38/367 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   237 AETTDKVKQGFWEEF-----ETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGD 296
            ||..||..|  |..|     ||..::..:..:|..|.:|..|:..|||:::.|:||:|:||..|.
  Fly    21 AEYKDKGPQ--WHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS 83

Human   297 PNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVE 361
                 .||||||::..|        :.::.||.|||.|.:||..||.||:::.||.::|..|.:|
  Fly    84 -----VDYINANLVQLE--------RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLME 135

Human   362 RGKSKCVKYWPDEY----ALK-EYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQ 421
            :.:.||..|||:|.    ||| .:..:.|..|:.....::..|..||:.     |:....|.|.|
  Fly   136 KKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTD-----LETQQSREVMQ 195

Human   422 YHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREK 486
            :|:.||||.|:||.|...|.||::|........|.||.||||||||||:|||.::|..:.:|.:.
  Fly   196 FHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY 260

Human   487 GVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQ--RRIEEEQ---KSKRKGHEY 546
            | :|  :|.|.:..:||.|.|::||..|..|.|.|:...|:.|.  ..::.|:   .:..:.|..
  Fly   261 G-EC--NVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTL 322

Human   547 TNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVG 588
            ..:...|..:......||.|.:.......||...|...|::|
  Fly   323 DELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIG 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203
SH2_C-SH2_SHP_like 111..218 CDD:198185
PTPc-N11 272..528 CDD:350453 99/260 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575 4/22 (18%)
Ptp61FNP_476687.1 PTPc-N1_2 63..291 CDD:350393 95/248 (38%)
Blue background indicates that the domain is not in the aligned region.

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