Protein Alignment PTPN11 and Ptp52F

DIOPT Version :10

• Sequence 1: NP_001317366.1
• Gene: PTPN11 / 5781
• HGNCID: 9644
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 148/520 - (28%)
• Similarity: 222/520 - (42%)
• Gaps: 136/520 - (26%)

Human    88 LKEKN-GDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLT--EKGKHGS------FLVRESQSH 143
            :.:|| ..|..|||.:      |..|          .|:|:  |.|..|:      :...|.:.|
  Fly   916 ISQKNCAGVPHLKYDV------SSDW----------PKVLSYQEAGADGTGDCSLEYQTTEERWH 964

Human   144 PGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTD---------------- 192
            |.......|.|:   .::|.:...|..:.:|.|::.....|..... ||
  Fly   965 PEPVQRQRRDGE---VTSDEEIVFTIGLDKCSEVQKTYCNGPLLPD-TDYNVVVRLFTASGYSDA 1025

Human   193 LVEHYKKNPMVE----------------TLG-TVLQLKQPL---------------NTTRINAAE 225
            .|.::|....::                .|| |||.:::.|               |....|.|.
  Fly  1026 AVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFGNVIAKNFAI 1090

Human   226 IESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290
            ..:.|.:..|||           .||:.:.....:|.||..|    ...:||||.:|.|:|..||
  Fly  1091 FYTEVAKPEKLA-----------REFKEITVVALELSYSASE----LGCHKNRYADIFPYDKNRV 1140

Human   291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVM 355
            :|   |.:...||||||:.|        :....||.||||||....:|.|||||:.|.|.||||.
  Fly  1141 IL---DIDAEGSDYINASFI--------DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ 1194

Human   356 TTKEVERGKSKCVKYWPDE-----YALKEYGVMRVRNVKE-SAAHD-YTLRELKLSKVGQALLQG 413
            .|:..|....||.:|:|..     ..:|...|:.:.:..| :..|| |.|:|
  Fly  1195 VTQFREGNTIKCHEYYPYNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKE------------- 1246

Human   414 NTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDI 478
                .|..|:|:.|||||||.||..::.|:::|  |.|......|:|||||||:|||||||.:|:
  Fly  1247 ----KVIHYYFKKWPDHGVPEDPMHLIMFVKKV--KAEKRPSYSPIVVHCSAGVGRTGTFIGLDL 1305

Human   479 LIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMA----VQHYIETLQRRIEEEQKS 539
            ::..::.   :..|::.:|::.:|.||..||||:.||.|:|..    |:|.|.....:::...||
  Fly  1306 IMQRLKS---ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRAALKMDGRPKS 1367

Human   540  539
              Fly  1368  1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	6/15 (40%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	26/162 (16%)
		PTPc-N11	272..528	CDD:350453	100/266 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..575
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	106/292 (36%)