Protein Alignment PTPN11 and Lar

DIOPT Version :10

• Sequence 1: NP_001317366.1
• Gene: PTPN11 / 5781
• HGNCID: 9644
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 160/604 - (26%)
• Similarity: 267/604 - (44%)
• Gaps: 140/604 - (23%)

Human     8 HPNITGVEAENLLL--TRGVDGSFLARPSKSNPGDFTLSVRRNGA--VTHIKIQNT-GDYYDLYG 67
            :.|:|..:...:.|  ..||.||....      .::....|::.|  .|...:|.| .|::.:..
  Fly  1506 YANVTAYDHSRVQLPAVEGVVGSDYIN------ANYCDGYRKHNAYVATQGPLQETFVDFWRMCW 1564

Human    68 GEKFATLAELV-----------QYY----MEHHGQLKEKNGDVIEL-KYPLN----CADPTSERW 112
            ..|.||:..:.           ||:    .|.:||:.....:..|| .|.:.    |....::|
  Fly  1565 ELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDR- 1628

Human   113 FHGHLSGKEAEKL-LTEKGKHGSFLVRESQSHPGDFVLSVR-----TGDDKGESNDGKSKVTHVM 171
                   :|.::| .|....||      ...||..|:..:|     |..:.|.          |:
  Fly  1629 -------REIKQLQFTAWPDHG------VPDHPAPFLQFLRRCRALTPPESGP----------VI 1670

Human   172 IRCQELKYDVGGGER-----FDSLTDLVEHYK--------------KNPMVETLGTVLQLKQPL- 216
            :.|     ..|.|..     .||:.:.::|.|              :|.||:|....:.:...:
  Fly  1671 VHC-----SAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL 1730

Human   217 -----NTTRINAAEIESRVREL--SKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENK 274
                 ..|.:.|..:.:.:::|  ::..||...::..| ::...::....|.:.:....    ||
  Fly  1731 EAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEF-KKLSNVKMDSSKFVTANLPC----NK 1790

Human   275 NKNRYKNILPFDHTRVVLHDGDPNEPV-----SDYINANIIMPEFETKCNNSKPKKSYIATQGCL 334
            :|||..:|||::.:||.|      .|:     |||:||:.|        :..:.:.:|||.||.:
  Fly  1791 HKNRLVHILPYESSRVYL------TPIHGIEGSDYVNASFI--------DGYRYRSAYIAAQGPV 1841

Human   335 QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLR 399
            |:...|||||:::.||.::||.||..|.|:.||.:|||.|.::: |....|..:.|.....|.||
  Fly  1842 QDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVR-YQYYVVDPIAEYNMPQYKLR 1905

Human   400 ELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCS 464
            |.|::..     :..:.|||.|:.|..||:.|||....|.:||:.:||..:|.....||:.||||
  Fly  1906 EFKVTDA-----RDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCS 1965

Human   465 AGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 529
            ||:||:|.||.:.|:::.::.:||   :||.:|::::||||..|||||.||.|.|.|...|:.:.
  Fly  1966 AGVGRSGVFITLSIVLERMQYEGV---LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSF 2027

Human   530 QRRIEEEQKSKRKGHEYTN 548
            .              .|||
  Fly  2028 D--------------NYTN 2032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	24/115 (21%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	24/137 (18%)
		PTPc-N11	272..528	CDD:350453	101/260 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..575
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	49/263 (19%)
		R-PTP-LAR-2	1784..2021	CDD:350402	100/263 (38%)