DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPN11 and Ptp36E

DIOPT Version :10

Sequence 1:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens
Sequence 2:NP_609872.1 Gene:Ptp36E / 35091 FlyBaseID:FBgn0267486 Length:682 Species:Drosophila melanogaster


Alignment Length:441 Identity:118/441 - (26%)
Similarity:201/441 - (45%) Gaps:91/441 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   182 GGGE----------RFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRIN--AAEIESR----- 229
            |||:          |:|   |:.:..:|:..:.::...::|.. ||:..::  ..::|:|     
  Fly    13 GGGKTGKHRSRSSARYD---DVEKQQRKSRAIVSIPNTIKLSM-LNSGLLSFERIKLEARDENNS 73

Human   230 -----------VRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNIL 283
                       :|...||.:...|....:..||:|..:.|..   :.:...::.|..||:....:
  Fly    74 LSKTIPNGPIDIRHFLKLCDLRRKFPVLYKLEFQTAAKVESN---TCRHALKKNNLEKNQNPKCI 135

Human   284 PFDHTRVVLHDGDPNEPV-----SDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWR 343
            |:|:.||||      |.|     |||:||:.:        ::.....:||.|||.::.||..:||
  Fly   136 PYDYNRVVL------EKVGGLQDSDYVNASYV--------DSLLKPNAYIVTQGPVEETVQAYWR 186

Human   344 MVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKE-YGVMRVRNVKESAAHDYTLRELKLSKVG 407
            ||:|||...|||.||..:..|..|.:|||....:.| ||.:.:..|:|....::.:|..:|.|:.
  Fly   187 MVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMN 251

Human   408 QALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVH------HKQESIMDAGPVVVHCSAG 466
            :. .:...||.:.|:|:..|..|..|.. ..:|:|...|.      .|.|..| .||::||||.|
  Fly   252 EK-QEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDM-RGPILVHCSDG 313

Human   467 IGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI----- 526
            .||:|.::.||..:::..|:  :| .:|...::.:|..|.|:|:...||:|||..::.:|     
  Fly   314 GGRSGVYMSIDANLELAEEE--EC-FNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKT 375

Human   527 ----ETLQRRIEEE--QKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTP 571
                ..|..|::.:  :.|..|.:||         |...||.    |..||
  Fly   376 WFPVSELSDRLKAKARRNSGTKMNEY---------QAEYDQI----CKQTP 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203
SH2_C-SH2_SHP_like 111..218 CDD:198185 9/45 (20%)
PTPc-N11 272..528 CDD:350453 86/276 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575 6/20 (30%)
Ptp36ENP_609872.1 Y_phosphatase 125..368 CDD:459674 85/262 (32%)
Y_phosphatase 428..671 CDD:459674
Blue background indicates that the domain is not in the aligned region.

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