Protein Alignment PTPN11 and ptpn11a

DIOPT Version :10

• Sequence 1: NP_001317366.1
• Gene: PTPN11 / 5781
• HGNCID: 9644
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_956140.1
• Gene: ptpn11a / 333979
• ZFINID: ZDB-GENE-030131-5911
• Length: 594
• Species: Danio rerio
• Alignment Length: 598
• Identity: 543/598 - (90%)
• Similarity: 563/598 - (94%)
• Gaps: 5/598 - (0%)

Human     1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish     1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65

Human    66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKG 130
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Zfish    66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKG 130

Human   131 KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQ-ELKYDVGGGERFDSLTDLV 194
            |:|||||||||||||||||||||||||.::::||.|||||||||| :|||||||||:||||||||
Zfish   131 KNGSFLVRESQSHPGDFVLSVRTGDDKTDTSEGKPKVTHVMIRCQHDLKYDVGGGEKFDSLTDLV 195

Human   195 EHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQEC 259
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
Zfish   196 EHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAEATDKVKQGFWEEFETLQQQEC 260

Human   260 KLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPK 324
            |||||||||||.|||||||||||||||||||||.|||.||..|||||||:|||:.|.|.||||.|
Zfish   261 KLLYSRKEGQRPENKNKNRYKNILPFDHTRVVLTDGDVNEQGSDYINANLIMPDNEAKSNNSKLK 325

Human   325 KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVK 389
            :||||||||||||::||||||||||||||||||||||||||||||||||..||||||.|||||||
Zfish   326 RSYIATQGCLQNTISDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDVSALKEYGAMRVRNVK 390

Human   390 ESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM 454
            |:.||||.||||||||||    ||||||||||||||.|||||||.||||||||||||..|||.|.
Zfish   391 ETMAHDYILRELKLSKVG----QGNTERTVWQYHFRAWPDHGVPGDPGGVLDFLEEVKLKQEGIT 451

Human   455 DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 519
            .|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   452 GAGPIVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 516

Human   520 MAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVY 584
            |||||||||||||||||||||.||.|||||||||:|.:.|||||||||||||.||:||:||:|||
Zfish   517 MAVQHYIETLQRRIEEEQKSKIKGREYTNIKYSLSDLSGGDQSPLPPCTPTPTCADMRDDSSRVY 581

Human   585 ENVGLMQQQKSFR 597
            |||||||||||.|
Zfish   582 ENVGLMQQQKSHR 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	97/97 (100%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	96/107 (90%)
		PTPc-N11	272..528	CDD:350453	224/255 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..575		17/22 (77%)
ptpn11a	NP_956140.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	97/97 (100%)
		SH2_C-SH2_SHP_like	111..219	CDD:198185	96/107 (90%)
		PTPc-N11	273..525	CDD:350453	224/255 (88%)