Protein Alignment PTPN11 and IA-2

DIOPT Version :10

• Sequence 1: NP_001317366.1
• Gene: PTPN11 / 5781
• HGNCID: 9644
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 148/618 - (23%)
• Similarity: 253/618 - (40%)
• Gaps: 134/618 - (21%)

Human    33 PSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIE 97
            |.:...||...::..|..|.: .||....:|.|:.|.                       ||||:
  Fly   758 PERKTAGDVARTINENRGVKN-NIQRRVGFYVLHAGV-----------------------GDVIK 798

Human    98 LKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGD------FV--LSVRTG 154
                 :..||:        :|....|  |.|:|...:.::....:..|.      ||  :.::..
  Fly   799 -----DLQDPS--------VSSSRIE--LAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRH 848

Human   155 DDKGESNDGK----------SKVTHVMIRCQELKYDVGGGERFDS--------------LTDLVE 195
            |.|.:...|.          ||....:.|.:......|||.....              :|.|.:
  Fly   849 DRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSK 913

Human   196 HYKKNPMVETLGTVLQLKQP------LNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETL 254
            ..:..|......|....::|      ::|..:..:.:|..:|...:|.           .|:|.|
  Fly   914 ENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQ-----------REWEAL 967

Human   255 QQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCN 319
            .:.|.: ..:|:...:.:....||....||:||:||||:. ..|....||:||:.|        .
  Fly   968 CRYEAE-PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH-LANAEGLDYVNASTI--------T 1022

Human   320 NSKPK-KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVM 383
            :..|: .:|:|.||.|.:|:..||:|::::.:.|||...:..|.|:..|.:|||:|.| :.|.:.
  Fly  1023 DHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGA-EVYHIY 1086

Human   384 RVRNVKESA-AHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVH 447
            .|..|.|.. ..||.:|...|..     |:.:..|||.|:||.:||..|||:....:|||..:|:
  Fly  1087 EVHLVSEHIWCDDYLVRSFYLKN-----LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVN 1146

Human   448 HKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE 512
            ......... |:|||.|||.||||.:|::|::::.: .||.. :||:..|::.:|.||:|:|.|.
  Fly  1147 KSYRGRRSC-PIVVHGSAGAGRTGVYILLDLVLERM-NKGAR-EIDIAATLEHLRDQRAGVVATR 1208

Human   513 AQYRFIYMAVQHYIETLQRRIEEEQKSKRK----------GHEYTNIKYSL----ADQTSGDQSP 563
            .|:.|:.|||...:..:.:.:......:::          |...|..|..|    |.:.:.:::|
  Fly  1209 QQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAP 1273

Human   564 LPPCTPTPPCAEMRE-----------DSARVYE 585
            ...........:.:|           |.|:|.|
  Fly  1274 TSSSKAAAAAKKEKEKDKDKEEKQAKDQAKVAE 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	14/69 (20%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	22/144 (15%)
		PTPc-N11	272..528	CDD:350453	90/257 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..575		3/26 (12%)
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	10/60 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	99/312 (32%)