DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPN11 and Ptp10D

DIOPT Version :10

Sequence 1:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens
Sequence 2:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster


Alignment Length:369 Identity:114/369 - (30%)
Similarity:180/369 - (48%) Gaps:66/369 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   247 FWEEFETL----QQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINA 307
            |.||||.|    :.|.|..      .....|:.|||:.||||:||:|..|...|.:|. ||||||
  Fly  1272 FSEEFEELKHVGRDQPCTF------ADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEG-SDYINA 1329

Human   308 NIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP 372
            |.:.       .::.|:: :|.|||.|.:|.:|||||.::.|||.|||.|:..|:|:.||.:|||
  Fly  1330 NYVP-------GHNSPRE-FIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP 1386

Human   373 DEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPG 437
            ::.....||.::|:.:.:|...|:.:.|..|.:       |:.:|.:..:||.||||.|||:.|.
  Fly  1387 NDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR-------GSEQRILRHFHFTTWPDFGVPNPPQ 1444

Human   438 GVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVR 502
            .::.|:.....:..:  :..|:|||||||:||:||||.:|.::..|.....   :|:...:..:|
  Fly  1445 TLVRFVRAFRDRIGA--EQRPIVVHCSAGVGRSGTFITLDRILQQINTSDY---VDIFGIVYAMR 1504

Human   503 SQRSGMVQTEAQYRFIYMAVQHYIETLQRRI-EEEQKSKRKGHEYTNIKY--------------- 551
            .:|..|||||.||..|:..:...:|..:..: ...:....:|:|...::.               
  Fly  1505 KERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLS 1569

Human   552 ----------SLADQTSG----DQSPLPPC-----TPTPPCAEM 576
                      ::.|:.:.    ||.||...     |..||...|
  Fly  1570 HHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSM 1613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203
SH2_C-SH2_SHP_like 111..218 CDD:198185
PTPc-N11 272..528 CDD:350453 94/255 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575 8/31 (26%)
Ptp10DNP_996413.2 fn3 124..205 CDD:394996
fn3 220..304 CDD:394996
FN3 278..>734 CDD:442628
FN3 583..671 CDD:238020
fn3 787..850 CDD:394996
fn3 866..935 CDD:394996
fn3 959..1043 CDD:394996
PTP_tm 1083..1187 CDD:465889
R3-PTPc 1301..1522 CDD:350396 91/241 (38%)
Blue background indicates that the domain is not in the aligned region.

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