Protein Alignment PTPN11 and Ptpmeg2

DIOPT Version :10

• Sequence 1: NP_001317366.1
• Gene: PTPN11 / 5781
• HGNCID: 9644
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Alignment Length: 301
• Identity: 117/301 - (38%)
• Similarity: 173/301 - (57%)
• Gaps: 39/301 - (12%)

Human   243 VKQ----GFWEEFETLQQQ--ECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPV 301
            |||    |..:|:..::.:  |...|::|    .:.|..||||.::|.:||:||||...|.:||
  Fly   525 VKQRGRHGLIKEYADIRNRAPEGTFLHAR----MRANLTKNRYTDVLCYDHSRVVLAHEDGDEP- 584

Human   302 SDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSK 366
            |||||||.:        :..|.|.:||:|||.|..|..|||||:::::..||||||:.:|||:.|
  Fly   585 SDYINANFV--------DGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVK 641

Human   367 CVKYW-PDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDH 430
            |.:|| |.|.:..|:|...||.:......||.:..|:|..:     :.:..|.|..:.|.:|||:
  Fly   642 CGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNI-----KTDEIRNVSHWQFTSWPDY 701

Human   431 GVPSDPGGVLDFLEEVHHKQESIMD------AG-----PVVVHCSAGIGRTGTFIVIDILIDIIR 484
            ||||....:|:||::|..||..::.      ||     |:|||||||||||||||.:||.|..:.
  Fly   702 GVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLE 766

Human   485 EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY 525
            :.|.   .|:..|::.:||||:..:|...||.|.::|:..|
  Fly   767 DVGT---ADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203
		SH2_C-SH2_SHP_like	111..218	CDD:198185
		PTPc-N11	272..528	CDD:350453	109/266 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..575
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	112/290 (39%)