DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPN11 and pyp2

DIOPT Version :10

Sequence 1:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens
Sequence 2:NP_594899.1 Gene:pyp2 / 2542200 PomBaseID:SPAC19D5.01 Length:711 Species:Schizosaccharomyces pombe


Alignment Length:424 Identity:122/424 - (28%)
Similarity:169/424 - (39%) Gaps:119/424 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   156 DKGESNDGKSKVTHVMIRCQELKYDVG----------GGER------FDSLTDLVEHYKKN---- 200
            |....|||.|.:|      .:||..||          ||.|      |:..|......|:|    
pombe   338 DSNAQNDGTSTMT------SKLKPSVGLSNTRDAPKPGGLRRANKPCFNKETKGSIFSKENKGPF 396

Human   201 ------------PMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFET 253
                        |..|.|..            :|.|.|..:.:.|.::..|....       |..
pombe   397 TCNPWGAKKVSPPPCEVLAD------------LNTASIFYKFKRLEEMEMTRSLA-------FND 442

Human   254 LQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKC 318
            .:...|.|..||.    .....||||.:|:|:|.|||.|  ..| :..||||||:.|        
pombe   443 SKSDWCCLASSRS----TSISRKNRYTDIVPYDKTRVRL--AVP-KGCSDYINASHI-------- 492

Human   319 NNSKPKKSYIATQGCLQNTVNDFWRMVFQEN--SRVIVMTTKEVERGKSKCVKYWPD--EYALKE 379
              ....|.|||.|.....|:.|||.||:..:  :.||||.|...|.|..||.:||||  ::||..
pombe   493 --DVGNKKYIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSEKCSQYWPDNKDHALCL 555

Human   380 YGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQY--HF--RTWPDHGVPSDPG--G 438
            .|.:|:...|.....|.        ||...|.:.:......:|  ||  .||.|...|....  |
pombe   556 EGGLRISVQKYETFEDL--------KVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPDIESITG 612

Human   439 VLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKT------ 497
            ::..:::|.:.       ||:.||||||:|||||||.:|.::.:  .|.:     :|||      
pombe   613 IIRCIDKVPND-------GPMFVHCSAGVGRTGTFIAVDQILQV--PKNI-----LPKTTNLEDS 663

Human   498 -------IQMVRSQRSGMVQTEAQYRFIYMAVQH 524
                   :..:||||..|||...|::|:|..|.:
pombe   664 KDFIFNCVNSLRSQRMKMVQNFEQFKFLYDVVDY 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203
SH2_C-SH2_SHP_like 111..218 CDD:198185 20/93 (22%)
PTPc-N11 272..528 CDD:350453 92/276 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575
pyp2NP_594899.1 DSP_MapKP 4..129 CDD:238723
PHA03247 <159..304 CDD:223021
PTP_fungal 486..693 CDD:350509 76/238 (32%)
Blue background indicates that the domain is not in the aligned region.

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