Protein Alignment HES4 and E(spl)m5-HLH

DIOPT Version :10

• Sequence 1: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Alignment Length: 194
• Identity: 46/194 - (23%)
• Similarity: 79/194 - (40%)
• Gaps: 51/194 - (26%)

Human    65 KPVMEKRRRARINESLAQLKTLIL-----DALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTA 124
            ||::|::||||:|:.|..||||:.     ||:       .:::||::||..   |..:|:..|..
  Fly    23 KPLLERQRRARMNKCLDTLKTLVAEFQGDDAI-------LRMDKAEMLEAA---LVFMRKQVVKQ 77

Human   125 ALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAA-CLRQLGPSRRPASLSPA 188
            .....|..:..::.|:...::|::|.:|....:..||...::.||.. ..|.|...:...|::.:
  Fly    78 QAPVSPLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTS 142

Human   189 APAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGP-------WRPW 245
            .|           |||.|:..|..                 :.....|....|       ||||
  Fly   143 TP-----------RPLSPASSGYH-----------------SDNEDSQSAASPKPVEETMWRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	21/60 (35%)
		Hairy_orange	135..174	CDD:462193	8/39 (21%)
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	22/64 (34%)
		ORANGE	87..131	CDD:128787	9/43 (21%)