Protein Alignment HES4 and E(spl)m3-HLH

DIOPT Version :10

• Sequence 1: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 211
• Identity: 56/211 - (26%)
• Similarity: 97/211 - (45%)
• Gaps: 32/211 - (15%)

Human    65 KPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRR-----VQ-VT 123
            ||::|::||||||:.|..||.|:::.|::|....::||||||||:||.|:|.|::     :| |.
  Fly    16 KPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSLQGVV 80

Human   124 AALSADP-----AVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPA 183
            |.:.:.|     |.:..:|:|:.....::.:.|...:... ::..:::..|:..|.:|.......
  Fly    81 AGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTD-EIGRKIMKFLSTRLIELQTQLLQQ 144

Human   184 SLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLL------------------PGLTRALPAA 230
            ........:...|: .:||...|.|||..|..|...:                  .|...:..|:
  Fly   145 QQQQQQHQQQQIPQ-SSGRLAFPLLGGYGPAAAAAAISYSSFLTSKDELIDVTSVDGNALSETAS 208

Human   231 PRAGPQGPGGP-WRPW 245
            ..:...|...| ||||
  Fly   209 VSSQESGASEPVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	28/60 (47%)
		Hairy_orange	135..174	CDD:462193	4/38 (11%)
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	28/54 (52%)
		ORANGE	96..136	CDD:128787	5/40 (13%)