Protein Alignment HES4 and E(spl)mgamma-HLH

DIOPT Version :10

• Sequence 1: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Alignment Length: 191
• Identity: 56/191 - (29%)
• Similarity: 91/191 - (47%)
• Gaps: 15/191 - (7%)

Human    65 KPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSAD 129
            ||::|::||||||:.|.:||.|::..|..|....::||||||||:||.||:.:::.:.....|.|
  Fly    20 KPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQHKRASGD 84

Human   130 PAVLGK--YRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAE 192
            .::...  :|:|:...:.||:|.|:...|:...:.::|:.||...|.|:.|:.:     ...|..
  Fly    85 ESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAEK-----EVLPVT 144

Human   193 APAPEVYAGR--------PLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPW 245
            ||.....|.|        |:....|.|....:......||...........:.....||||
  Fly   145 APLSVHIANRDAYSVPISPISSYAGSPNSNTSSTSHSLLTTIDVTKMEDDSEDEENVWRPW 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	27/55 (49%)
		Hairy_orange	135..174	CDD:462193	10/40 (25%)
E(spl)mgamma-HLH	NP_524504.2	bHLH-O_ESMB_like	9..77	CDD:381584	27/56 (48%)
		ORANGE	91..135	CDD:128787	12/43 (28%)