Protein Alignment HES4 and hry

DIOPT Version :10

• Sequence 1: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_523977.2
• Gene: hry / 38995
• FlyBaseID: FBgn0001168
• Length: 337
• Species: Drosophila melanogaster
• Alignment Length: 211
• Identity: 82/211 - (38%)
• Similarity: 112/211 - (53%)
• Gaps: 47/211 - (22%)

Human    54 GTQPVP----------DPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILE 108
            ||..||          |.:|:||:||||||||||..|.:||||||||.:|:.:||||||||||||
  Fly    15 GTAVVPAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILE 79

Human   109 MTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACL 173
            .||:||:.|:|.|.....:|||.::.|::|||.:|:.||:||    .|:....|.|||.||:.|:
  Fly    80 KTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQRRRLLQHLSNCI 140

Human   174 -----------RQLGPSRRPASLSPAAPAE--------APAPEVYA------------GRPLLPS 207
                       ||.......|.:.|:.|:.        |.||.::.            |..::|:
  Fly   141 NGVKTELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPT 205

Human   208 L--GGPFPLLAPPLLP 221
            .  .|...|:.|..||
  Fly   206 KLPNGSIALVLPQSLP 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	41/58 (71%)
		Hairy_orange	135..174	CDD:462193	17/49 (35%)
hry	NP_523977.2	bHLH-O_hairy_like	30..88	CDD:381483	40/57 (70%)
		ORANGE	106..141	CDD:128787	17/38 (45%)