DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MARK4 and KP78b

DIOPT Version :10

Sequence 1:NP_001186796.1 Gene:MARK4 / 57787 HGNCID:13538 Length:752 Species:Homo sapiens
Sequence 2:NP_650065.1 Gene:KP78b / 41361 FlyBaseID:FBgn0026063 Length:604 Species:Drosophila melanogaster


Alignment Length:635 Identity:266/635 - (41%)
Similarity:356/635 - (56%) Gaps:128/635 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     9 PGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHV-----GNYRLLRTIGKG 68
            ||.:.:..|..|..|..:.:.|..:.|.  |.|      |.|:.|.:|     |.|::::|:|||
  Fly    16 PGPNTSISTTATPPSAAAQNVGGCFGSS--GGR------SSPKFQSYVNGNGYGVYKIIKTLGKG 72

Human    69 NFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYL 133
            ||||||||.|:.||||||||:||||.||..:.|||:|||.|||.|||||||:|.:|||:|:||||
  Fly    73 NFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLYL 137

Human   134 VMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIA 198
            ||||.|.||:|:|||.:|||:|::||..|||:|||:.|||.|:||||||||||||||.:..:|||
  Fly   138 VMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIA 202

Human   199 DFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE 263
            |||||..|...:.|:||||||||||||||:||||.|||||.|||||:|||||||||||||.||||
  Fly   203 DFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKE 267

Human   264 LRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYE-GEELKPYTEPEE 327
            ||:||||||||||:|:|.:|||::|:||||||.:|.:|..:|.|:|||:||| |..|:|:.|...
  Fly   268 LRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKPM 332

Human   328 DFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLG----RKT---EEGGD------RGA 379
            |..|..|:.::..||:...::::||.:||::::..||:||.    |.|   |:.|.      ...
  Fly   333 DLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTAM 397

Human   380 PGLALARVRAPSDTTNGTSS------SKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRS 438
            ||  .:|:..|....|.|.|      .|.|.:.....|......|...     ..:|.||.|   
  Fly   398 PG--SSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAPRLAN-----ALTPLPLTP--- 452

Human   439 PTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPP 503
                          |.:|..|.:|              |.|.||.::|           |:::|.
  Fly   453 --------------PPKKYICCSA--------------SKAANPRRSE-----------PSSIPQ 478

Human   504 SMMTR---------RNTYVCTERPGAERPSL----------LPNGKENSSGTPRVPP-------- 541
            |.|.:         :.|.:..:|..|....|          :......:|...|.||        
  Fly   479 SAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQIRSPITQSPSQASECTRTPPTHFEMLDS 543

Human   542 -ASP-------SSHSLAPPSGER----------SRLARGSTIRSTFHGGQ 573
             ::|       :|:|..|||.|.          |:|: ...:|.:.|.|:
  Fly   544 TSTPLKVLKLVASNSQTPPSTENTNRPTRVGFFSKLS-ARFVRRSLHKGE 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MARK4NP_001186796.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 6/26 (23%)
STKc_MARK 58..310 CDD:270974 177/251 (71%)
UBA_MARK3_4 328..370 CDD:270590 13/45 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..614 46/240 (19%)
MARK4_C 654..752 CDD:213382
KP78bNP_650065.1 Protein Kinases, catalytic domain 63..314 CDD:473864 177/250 (71%)
UBA_MARK_Par1 335..373 CDD:270522 11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

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