Protein Alignment PTPN7 and PTP-ER

DIOPT Version :9

• Sequence 1: XP_011508121.1
• Gene: PTPN7 / 5778
• HGNCID: 9659
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 862
• Identity: 174/862 - (20%)
• Similarity: 243/862 - (28%)
• Gaps: 442/862 - (51%)

Human     9 THSQGTGPWAPEGHRREAADPWWQRQQAQEGRMQLGCAWVAARRGGGRKLASWSLLSPQRQTDRQ 73
            |.||......|:.|...::      |.:::|..:        |||....:.        .:|...
  Fly   579 TASQIRADQLPQSHLLGSS------QGSRQGLFR--------RRGSNHSIT--------LKTGHT 621

Human    74 TDSWQEAAWGPQLLQQTSWLSEPPLG-------------------PAPHLSMVQAHGGRSRAQPL 119
            |.|..:.....||.||.:.||.....                   |.|...:::..|..   |.|
  Fly   622 TTSCGDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSN---QSL 683

Human   120 TLSLG--------------------------AAMTQPPPEK------------------------ 134
            ||::|                          ||..|.|.::
  Fly   684 TLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCF 748

Human   135 --------TPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPRE-----VTLHFLRTAGHP 186
                    .|.:..||..:..|:.......||:: ...|:....|..|     .::..|::|.:|
  Fly   749 GSASDLQPNPQQDSVREDQAIGATCTCAGTVRNI-MTRPLSPQTTSEEFKIYLASIQMLQSASNP 812

Human   187 LTRWALQR-----------------QPP----------------SPKQLEEEFLKIPSNFVS--- 215
            |.::.|.|                 |||                .|...:.|.|......||
  Fly   813 LNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMA 877

Human   216 ---PE-----------DL-----DIP----------GHASKDRYKTILPNPQSRVCLGRAQSQ-- 249
               ||           ||     |:|          |..:|:||||||||..|||.|....|:
  Fly   878 QPIPELKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELT 942

Human   250 ---------------EDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQ--------- 290
                           ||..|||||||:|.|...|.|:|||||:|||:.:||.|::|
  Fly   943 SLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRC 1007

Human   291 -------------EEV-----SLIVMLTQLRE-GKEKCVHYWPTE-------------------- 316
                         |::     ..|||||...| .::||..|:|.|
  Fly  1008 VDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAA 1072

Human   317 --------EETYGP----------------FQIRIQDMKECPE---------------------- 335
                    ..|:.|                ..|.::.:|...|
  Fly  1073 RDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIV 1137

Human   336 ----YTVRQLTI----------QYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEV------- 379
                |:||:|.:          .|..::....|..:..||||.:|.....||.....|
  Fly  1138 RRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCE 1202

Human   380 -------EESPETAAH------------------PGPIVVHCSAGIGRTGCFIATRIGCQQLKAR 419
                   :...|..||                  |.| |:||||||||||||.|.....:||:..
  Fly  1203 SEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLP-VIHCSAGIGRTGCFTAILNAVRQLRQS 1266

Human   420 -----------------------------------------------GE---------------- 421
                                                           .|
  Fly  1267 LAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPD 1331

Human   422 --VDILGIVCQLRLDRLLERRKLEAQEYSWPDPRLQRSGFVPGAEWIKEDQVSTWGITPQHVGGM 484
              ||:|||||.|||.|                                              |||
  Fly  1332 IFVDVLGIVCNLRLQR----------------------------------------------GGM 1350

Human   485 IQTAEQYQFLHHTLALY 501
            :|.:|||:.:|..:.||
  Fly  1351 VQNSEQYELIHRAICLY 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN7	XP_011508121.1	PTPc	201..499	CDD:214550	122/551 (22%)
		PTPc	227..499	CDD:238006	111/493 (23%)
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	111/494 (22%)
		PTPc	917..1364	CDD:238006	111/493 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3565
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	4.010