DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPN6 and Ptp99A

DIOPT Version :10

Sequence 1:NP_536859.1 Gene:PTPN6 / 5777 HGNCID:9658 Length:624 Species:Homo sapiens
Sequence 2:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster


Alignment Length:410 Identity:135/410 - (32%)
Similarity:207/410 - (50%) Gaps:51/410 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   205 AFVYLRQPYYATRVNAADIENRVL---ELNKKQESEDTAK----------AGFWEEFESLQKQEV 256
            |:.||..|.:.......|.|..|.   |:.......:.||          .||..|:|::|.:.:
  Fly   595 AYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECI 659

Human   257 KNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ---GRDSNIPGSDYINANYIKNQLLGPDENA 318
            .:.......|.||||.||||.||..:|||||.|.   |:..|:   ||||||:|...     :..
  Fly   660 SDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNL---DYINANFIDGY-----QKG 716

Human   319 KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCG 383
            ..:|.:||.|..|.:.||:|.|::...:|||.|..||:||.||..|||:.|:: .||...|....
  Fly   717 HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE-TYGVIQVKLIE 780

Human   384 EHDTTEYKLRTLQVSPLD-------NGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE 441
            |...:.|.:||||:..|.       |.:.:  ::.|.|.:|||||.|..|..||:|:.:.:....
  Fly   781 EEVMSTYTVRTLQIKHLKLKKKKQCNTEKL--VYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANP 843

Human   442 SLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK 506
            :  .||||:||||||:|||||.||:|.:::.|..|.:   :::...::.:||||:.:||||.||.
  Fly   844 A--EAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYI 903

Human   507 FIYVAIAQFIETTKKKLEVLQSQKGQ------ESEYGN-ITYPPAMKNAHAKASRTSSKSLESSA 564
            |::.|:.:.|.:.:..|...|.::.:      |.:|.| |.:.|  |:.|..::.....|:::..
  Fly   904 FLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQP--KDIHIASAMKQVNSIKNRG 966

Human   565 GTVAASPVRRGGQRGLPVPG 584
               |..|:........|.||
  Fly   967 ---AIFPIEGSRVHLTPKPG 983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPN6NP_536859.1 SH2_N-SH2_SHP_like 3..101 CDD:198203
SH2_C-SH2_SHP_like 109..215 CDD:198185 4/9 (44%)
PTPc-N6 253..518 CDD:350454 105/274 (38%)
Ptp99ANP_651691.4 FN3 140..236 CDD:238020
FN3 243..337 CDD:238020
fn3 343..430 CDD:394996
FN3 442..520 CDD:238020
R5-PTPc-1 704..907 CDD:350397 83/215 (39%)
R5-PTP-2 989..1182 CDD:350398
Blue background indicates that the domain is not in the aligned region.

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