DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPN6 and Ptp69D

DIOPT Version :10

Sequence 1:NP_536859.1 Gene:PTPN6 / 5777 HGNCID:9658 Length:624 Species:Homo sapiens
Sequence 2:NP_524048.2 Gene:Ptp69D / 39443 FlyBaseID:FBgn0014007 Length:1462 Species:Drosophila melanogaster


Alignment Length:409 Identity:129/409 - (31%)
Similarity:192/409 - (46%) Gaps:80/409 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   166 HIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLR--------------QPYYAT 216
            ::.:..:.|...:|.:..|..|  .|.|.|||..|......:.||              ..::.|
  Fly   799 YLSIGVKAGAVLLGVILVFIVL--WVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFIT 861

Human   217 RVN-----AADIENRVLELNKKQESEDTAKAGFWEEFESL----QKQEVKNLHQRLEGQRPENKG 272
            ..|     |..|....||...|...:|| ..||..|:|.|    ..:..||      ....||..
  Fly   862 SGNHKGFDAGPIHRLDLENAYKNRHKDT-DYGFLREYEMLPNRFSDRTTKN------SDLKENAC 919

Human   273 KNRYKNILPFDHSRV---ILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVND 334
            ||||.:|..:|.:||   ::.|    :..:||||||::    :|..|. |.:|.:||.:|:|::|
  Fly   920 KNRYPDIKAYDQTRVKLAVING----LQTTDYINANFV----IGYKER-KKFICAQGPMESTIDD 975

Human   335 FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE-VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVS 398
            ||:|.|:::..:|||.|...|..:.||..|||| |...:.:|...|....|..|.:|..|||.||
  Fly   976 FWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVS 1040

Human   399 P----LDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQIN-----QRQESLPHAGPIIVHCS 454
            .    :...:..|:|..|.||:|.|...|..|.|::.|:.|||     ||       |||:||||
  Fly  1041 KNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR-------GPILVHCS 1098

Human   455 AGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI------- 512
            ||:|||||::.:|.|::.:..:.   .:.|..|:..:|.||:.:||:..||.|:|.|:       
  Fly  1099 AGVGRTGTLVALDSLIQQLEEED---SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFG 1160

Human   513 ---------AQFIETTKKK 522
                     |..||:.|:|
  Fly  1161 NTDICIDTMASAIESLKRK 1179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPN6NP_536859.1 SH2_N-SH2_SHP_like 3..101 CDD:198203
SH2_C-SH2_SHP_like 109..215 CDD:198185 12/62 (19%)
PTPc-N6 253..518 CDD:350454 100/293 (34%)
Ptp69DNP_524048.2 Ig_3 35..114 CDD:464046
Ig_3 134..216 CDD:464046
fn3 237..321 CDD:394996
FN3 <300..>524 CDD:442628
PTPc 892..1155 CDD:214550 103/287 (36%)
PTPc 1186..1449 CDD:214550
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.