Protein Alignment PTPN6 and Lar

DIOPT Version :10

• Sequence 1: NP_536859.1
• Gene: PTPN6 / 5777
• HGNCID: 9658
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Alignment Length: 393
• Identity: 138/393 - (35%)
• Similarity: 191/393 - (48%)
• Gaps: 69/393 - (17%)

Human   232 KKQESEDTAKAGFWEEFESLQK-QEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSN 295
            ::.:|.|..|  |.:|:||::. |:....:..||    .||.||||.|:..:|||||.|...: .
  Fly  1467 ERLKSNDNQK--FSQEYESIEPGQQFTWDNSNLE----HNKSKNRYANVTAYDHSRVQLPAVE-G 1524

Human   296 IPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360
            :.|||||||||....     .....|:|:||.|:.|..|||:|.|:..:..|||.||..|:.|.|
  Fly  1525 VVGSDYINANYCDGY-----RKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIK 1584

Human   361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSE 425
            |..|||..|.: .||...||.....:...|.:||.|:......|. |||...|:.:|||||||..
  Fly  1585 CDQYWPTRGTE-TYGQIFVTITETQELATYSIRTFQLCRQGFNDR-REIKQLQFTAWPDHGVPDH 1647

Human   426 PGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQM 490
            |...|.||.:.  |..:.|.:||:|||||||:||||..||||.::|.:..:.:   |||...:..
  Fly  1648 PAPFLQFLRRC--RALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKI---IDIYGHVTC 1707

Human   491 VRAQRSGMVQTEAQYKFIYVAI------------AQFIETTKKKL---EVLQSQKGQESEYGNIT 540
            :||||:.|||||.||.||:.||            |:.:.|..:||   |..::..|.|.|:
  Fly  1708 LRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEF---- 1768

Human   541 YPPAMKNAHAKASRTSSKSLESSAGTVAASPVRRGGQRGLPVPGPPVLSPDLHQLP------VLA 599
                        .:.|:..::||....|..|..:...|            .:|.||      .|.
  Fly  1769 ------------KKLSNVKMDSSKFVTANLPCNKHKNR------------LVHILPYESSRVYLT 1809

Human   600 PLH 602
            |:|
  Fly  1810 PIH 1812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN6	NP_536859.1	SH2_N-SH2_SHP_like	3..101	CDD:198203
		SH2_C-SH2_SHP_like	109..215	CDD:198185
		PTPc-N6	253..518	CDD:350454	112/277 (40%)
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	109/253 (43%)
		R-PTP-LAR-2	1784..2021	CDD:350402	9/41 (22%)