Protein Alignment PTPN6 and Pez

DIOPT Version :10

• Sequence 1: NP_536859.1
• Gene: PTPN6 / 5777
• HGNCID: 9658
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 86/294 - (29%)
• Similarity: 135/294 - (45%)
• Gaps: 49/294 - (16%)

Human   247 EFESLQKQEVKNLHQ--RLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKN 309
            |||.:.|:....|::  .||    ||:.||...|.||:|.:||.|.....|..|  |:||:.| :
  Fly   986 EFERIPKRREHALYECALLE----ENEPKNHDPNFLPYDDNRVRLTPCRDNRHG--YVNASSI-S 1043

Human   310 QLLGPDENAKTYIASQGCLE-ATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP------- 366
            ..:|..:  :.||.:|...| .|:..|||..|:.:..::|..|.::.        |.|
  Fly  1044 ATVGTKQ--RFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSHQRL 1098

Human   367 EVGMQRAYGPYSVT--NCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGV 429
            |.|..:.|..:|.|  .|     |..|||...|.    ....|.:|:.||..|.:...|.:....
  Fly  1099 EFGQFQVYQEFSQTTDRC-----TTIKLRLYHVP----SRRYRSVWYLQYADWAEQNCPRDVNHF 1154

Human   430 LSFLDQIN-----QRQESLPHAG---PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQK 486
            |.||:::|     ..||..|...   |:::||..|.||:|..:..|:|:..:....   |:||.:
  Fly  1155 LDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNE---DLDIPR 1216

Human   487 TIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520
            .|..:|.||..::.:.|||||||..:..:::.|:
  Fly  1217 VIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN6	NP_536859.1	SH2_N-SH2_SHP_like	3..101	CDD:198203
		SH2_C-SH2_SHP_like	109..215	CDD:198185
		PTPc-N6	253..518	CDD:350454	82/284 (29%)
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		PTP_DSP_cys	1036..1246	CDD:475123	65/232 (28%)