Protein Alignment PTPN6 and IA-2

DIOPT Version :10

• Sequence 1: NP_536859.1
• Gene: PTPN6 / 5777
• HGNCID: 9658
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 156/627 - (24%)
• Similarity: 255/627 - (40%)
• Gaps: 153/627 - (24%)

Human    45 VGDQVTHIRIQNSGDFYDLYGGEKFATLTELV-------EYYTQQQGVLQDRDGTIIHLKYPLNC 102
            |..:..|:.::|..|.::  .|::.....|.:       .|.|.||.          .:.:.:|.
  Fly   703 VDTEYVHVFVKNPIDSWN--DGQRIMKELEQILHMQGYFSYLTVQQH----------EVSFRVNS 755

Human   103 SDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLS-QPGDFVL--------------SVLSD 152
            ::|  ||    ..:|..|.|:.:.:|      |:.::. :.|.:||              ||.|.
  Fly   756 NNP--ER----KTAGDVARTINENRG------VKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSS 808

Human   153 QPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKK-----------TGIEEASGAF 206
            :.:.....| .||||......|......:..|.:|..:..|.:|           .|.|..|..:
  Fly   809 RIELAEQGP-DVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDY 872

Human   207 VYLRQPYYATRV---------------NAADIENRVLELNKKQES---EDTAKAGFWEEFESLQK 253
            ..|.:...|.:.               |......|:..|:|:.|.   ...:....|.|..:|..
  Fly   873 QELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTN 937

Human   254 QEVKNLHQ-------------RLE------------------GQRPENKGKNRYKNILPFDHSRV 287
            .::...|.             ||:                  ..:|:..|.||....||:|||||
  Fly   938 MDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRV 1002

Human   288 ILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTR 352
            :| ...:|..|.||:||:.|.:.    |..|..|:|:||.|.:|:..||||.|::.:.|||...|
  Fly  1003 VL-NHLANAEGLDYVNASTITDH----DPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCR 1062

Human   353 EVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD-TTEYKLRTLQVSPLDNGDLIREIWHYQYLS 416
            ..|.|...|..||||.|.: .|..|.|....||. ..:|.:|:..:..|...: .|.:..:.:||
  Fly  1063 LQENGEVACARYWPEEGAE-VYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSE-TRTVTQFHFLS 1125

Human   417 WPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD 481
            ||..|||::...:|.|..::|:.... ..:.||:||.|||.||||..|::|:::|.:: ||.. :
  Fly  1126 WPHMGVPAQAKALLDFRRKVNKSYRG-RRSCPIVVHGSAGAGRTGVYILLDLVLERMN-KGAR-E 1187

Human   482 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE----------------------------- 517
            |||..|::.:|.||:|:|.|..|::|:.:|:|:.:.
  Fly  1188 IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSS 1252

Human   518 -TTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSK 558
             |||:.|:..::|:..|.|     .|.:...|.|.|.:...|
  Fly  1253 TTTKEPLKEDKAQEAAEEE-----APTSSSKAAAAAKKEKEK 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN6	NP_536859.1	SH2_N-SH2_SHP_like	3..101	CDD:198203	10/62 (16%)
		SH2_C-SH2_SHP_like	109..215	CDD:198185	26/131 (20%)
		PTPc-N6	253..518	CDD:350454	96/326 (29%)
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	21/113 (19%)
		PTP_DSP_cys	942..1225	CDD:475123	96/292 (33%)