DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRIB3 and HSL1

DIOPT Version :9

Sequence 1:	NP_001288130.1	Gene:	TRIB3 / 57761	HGNCID:	16228	Length:	385	Species:	Homo sapiens
Sequence 2:	NP_012821.2	Gene:	HSL1 / 853760	SGDID:	S000001584	Length:	1518	Species:	Saccharomyces cerevisiae

Alignment Length:	322	Identity:	86/322 - (26%)
Similarity:	136/322 - (42%)	Gaps:	58/322 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    83 PDRATAVATAS-------RLGPYVL---LEPEEGGRAYQALHCPTGTEYTCKVYPVQEAL----- 132
            ||...:|||.|       .:||:.|   |.....||...|.:..||.....|:.|.::|.
Yeast    59 PDSTVSVATKSSKRKSRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSN 123

Human   133 ------------------------------AVLEPYA--------RLPPHKHVARPTEVLAGTQL 159
                                          :...||.        :|..|.:|....||......
Yeast   124 NGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSE 188

Human   160 LYAFFTRTH-GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERK 223
            ||....... |::...:.|:.::||.||...|:|:...:::||...:..|||| ...:..|::.:
Yeast   189 LYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLK-PENLLLDKKNR 252

Human   224 KLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPF 288
            ::.:.:. ....|..|:..|......|.|..|||:..| .|.|..:||||.|:.||.:|.||.||
Yeast   253 RIKIADF-GMAALELPNKLLKTSCGSPHYASPEIVMGR-PYHGGPSDVWSCGIVLFALLTGHLPF 315

Human   289 QDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQ-DPMPL 349
            .|.....|..|::.|.|.:|:.||:.||.|:..:|..:|.:|:|...||.||.::: |.:|:
Yeast   316 NDDNIKKLLLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIKKYDDLPV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIB3	NP_001288130.1	PK_TRB3	101..342	CDD:270926	75/284 (26%)
TRIB3	NP_001288130.1	S_TKc	107..342	CDD:214567	74/278 (27%)
HSL1	NP_012821.2	STKc_BRSK1_2	79..369	CDD:270983	78/292 (27%)
HSL1	NP_012821.2	AMPKA_C_like	1347..1517	CDD:418410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910