Protein Alignment TRIB3 and KCC4

DIOPT Version :10

• Sequence 1: NP_001288130.1
• Gene: TRIB3 / 57761
• HGNCID: 16228
• Length: 385
• Species: Homo sapiens
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 381
• Identity: 91/381 - (23%)
• Similarity: 146/381 - (38%)
• Gaps: 116/381 - (30%)

Human    87 TAVATASRLGPYVLLEP---EEGGRAYQALHCPTGTEYTCKV--------------------YPV 128
            :|...:|.:||:.|.|.   ...|:...|.|..||.....||                    |.:
Yeast    10 SAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNI 74

Human   129 QEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTH-GDMHSLVRSRHRIPEPEAAVLFRQ 192
            :..:.::    :|..|.:|....:|......||....... |::.:|:.....:||.||...|||
Yeast    75 EREIVIM----KLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQ 135

Human   193 MATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLEN--------------------LEDSCVLT 237
            :...:::||..|:|.||||          .:.|:|::                    ||.||
Yeast   136 IIIGISYCHALGIVHRDLK----------PENLLLDSFYNIKIADFGMAALQTDADLLETSC--- 187

Human   238 GPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS----EPVLLFG 298
                      ..|.|..|||:|. ..|.|.|:||||.||.||.:|.|..||.:.    ..:||
Yeast   188 ----------GSPHYAAPEIVSG-LPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLL-- 239

Human   299 KIRRGAYALP--AGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDP--------------- 346
            |:::|.:.:|  ..:|..|:.|:..:|..:|.:|:....||.||.|::..
Yeast   240 KVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPREN 304

Human   347 ---MPLAPTRSH---------------LWEAAQVVPDGLGLDEAREEEGDREVVLY 384
               .|||.:.:|               ||.....  |.: :.:.:|...::|.:||
Yeast   305 TYLYPLADSNNHTSASIDDSILQNLVVLWHGRHA--DDI-VSKLKENGTNKEKILY 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB3	NP_001288130.1	PK_TRB3	101..342	CDD:270926	74/290 (26%)
KCC4	NP_009907.2	Protein Kinases, catalytic domain	19..285	CDD:473864	77/295 (26%)
		Kcc4p_like_C	920..1034	CDD:213379