Protein Alignment TRIB3 and nipi-3

DIOPT Version :10

• Sequence 1: NP_001288130.1
• Gene: TRIB3 / 57761
• HGNCID: 16228
• Length: 385
• Species: Homo sapiens
• Sequence 2: NP_510573.3
• Gene: nipi-3 / 181650
• WormBaseID: WBGene00010700
• Length: 655
• Species: Caenorhabditis elegans
• Alignment Length: 356
• Identity: 81/356 - (22%)
• Similarity: 140/356 - (39%)
• Gaps: 56/356 - (15%)

Human    13 MSANNDHFLTPTWQQMRATPLA-------APAGS-----LSRKKRLELDDNL-DTERPVQKRARS 64
            :.|.|||::..|...|  .|.|       .||..     |:..:.|.|...| :.|:..|..|.|
 Worm   118 IKALNDHYVQLTRGSM--VPAADLYNNGDHPAEQRIPTMLNENEYLRLIQELEEEEKSKQFSATS 180

Human    65 GPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQ 129
            ...|.:.|.           .|..:.....:|.:|:...   |...:|:...|...:|..|.|..
 Worm   181 SSAPHVNPY-----------SAQHLVNGEIIGIFVIYGT---GLVTRAVCSQTREMFTAHVLPEW 231

Human   130 EALAVLEPYARLPPHKHVARPT---------------EVLAGTQLLYAFFTRTHGDMHSLVRSR- 178
            :|..|::...||.....::..|               |::................:||....|
 Worm   232 KASKVIDVIRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILMNPCESATIHSYATERL 296

Human   179 HRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLEN--LED-SCVLTGPD 240
            ..|.|.:...:::::...:..||...::|::.|...|........|.|:..  |:| ||.....:
 Worm   297 DEITENDVMSIYQKVVEIVRFCHSRKVILQNFKPRSFYLKKDAHNKWVVRPCFLQDMSCEEDQSE 361

Human   241 DSLWDKHACPAYVGPEILSSRA----SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIR 301
            .....:..|..::.||:|::.:    |||   .::|.|||.|:.:|.|.|||.::...|||..|:
 Worm   362 AQFTRRSVCVPFMAPEMLTAESRTHHSYS---TELWGLGVLLYILLTGKYPFHENSMPLLFRTIK 423

Human   302 RGAYALPAG-LSAPARCLVRCLLRREPAERL 331
            ...:..|.. :|:.:|.:|..||::.||.|:
 Worm   424 FKQHRWPFNFISSKSRNIVNMLLKKAPATRM 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB3	NP_001288130.1	PK_TRB3	101..342	CDD:270926	58/255 (23%)
nipi-3	NP_510573.3	Protein Kinases, catalytic domain	208..459	CDD:473864	58/253 (23%)