DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPN4 and CDC14

DIOPT Version :9

Sequence 1:	NP_002821.1	Gene:	PTPN4 / 5775	HGNCID:	9656	Length:	926	Species:	Homo sapiens
Sequence 2:	NP_116684.3	Gene:	CDC14 / 850585	SGDID:	S000001924	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	501	Identity:	95/501 - (18%)
Similarity:	166/501 - (33%)	Gaps:	177/501 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   121 YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQS-------ELGDYD------------QSEN 166
            |:...:.:.| ||::.|...........|.||.::|       |.||::            |.::
Yeast   132 YSNADFEITI-QDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQEDH 195

Human   167 LSGYLSDYSFIPNQPQDFEKEI-------------------AKLHQQHIGLSPAEAEF------- 205
            ..|||:..|...|||  |:..:                   .|.|.:.||:...:..|
Yeast   196 PKGYLATKSSHLNQP--FKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPD 258

Human   206 -----NYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKC 265
                 |::..|.|:                     :..||                   ||:..|
Yeast   259 LSIVKNFVGAAETI---------------------IKRGG-------------------KIAVHC 283

Human   266 KQFFIQLRKELHESRETLLGFNMV-NYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGS 329
            |...        .....|:|.::: .|....|   .|:....|.|....:.||:::...:.....
Yeast   284 KAGL--------GRTGCLIGAHLIYTYGFTAN---ECIGFLRFIRPGMVVGPQQHWLYLHQNDFR 337

Human   330 KFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA---------------RKLMDWEVVSRNSIS 379
            :::|..|..::                  ||:.:.               :||.|.:.|::|:|.
Yeast   338 EWKYTTRISLK------------------PSEAIGGLYPLISLEEYRLQKKKLKDDKRVAQNNIE 384

Human   380 DD-RLETQSLPSR----------SPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFV 433
            .: |..|.:.||.          |.|.|.|:.:::|  :.:.:..:|.|........::..|...
Yeast   385 GELRDLTMTPPSNGHGALSARNSSQPSTANNGSNSF--KSSAVPQTSPGQPRKGQNGSNTIEDIN 447

Human   434 NQRSPSSTQANSIVLESSPS-----QETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINE 493
            |.|:|:|.....:|:||:.|     |:|.|....   .||.|:|.  |.|. |.|...:|.:
Yeast   448 NNRNPTSHANRKVVIESNNSDDESMQDTNGTSNH---YPKVSRKK--NDIS-SASSSRMEDN--- 503

Human   494 TFDIPSSPEKPTPNGGIPHDNLVLIRMKPDE----NGRFGFNVKGG 535
                    |....|.....|:.:|.::.|..    :||...:..||
Yeast   504 --------EPSATNINNAADDTILRQLLPKNRRVTSGRRTTSAAGG 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPN4	NP_002821.1	B41	30..222	CDD:214604	29/150 (19%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	12/94 (13%)
		FA	325..365	CDD:312314	4/54 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..412		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..475		16/49 (33%)
		PDZ_signaling	515..602	CDD:238492	6/25 (24%)
		PTPc	682..909	CDD:238006
		Substrate binding. /evidence=ECO:0000250	852..858
CDC14	NP_116684.3	DSPn	14..151	CDD:405373	5/19 (26%)
		CDC14_C	161..340	CDD:350349	38/231 (16%)
		PRK08581	403..>513	CDD:236304	30/128 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910